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Catalog No.S1251 Synonyms: STS 557

Dienogest Chemical Structure

CAS No. 65928-58-7

Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.

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Biological Activity

Description Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
progestogen Receptor [1]
In vitro

Dienogest activates progesterone receptor (EC50=3.4 or 10.5 nM) with antagonistic activity on androgen receptor (EC50=420.6 or 775.0 nM) but not agonistic nor antagonistic action on GR, MR (3000 nM). [1] Dienogest combined with Oestradiol leads to an increase in the levels of prolactin mRNA and prolactin production in a dose-dependent manner in human endometrial stromal cells (ESC). Dienogest directly acts on endometrial tissue in progestogenic response, such as decidualization, increases prolactin production and growth retardation. [2] Dienogest at concentration of 0.1 μM and 1 μM significantly inhibits BrdU incorporation into DNA at 24 and 48 hours in the cultured endometriotic stromal cells. Dienogest significantly increases the cells in G0/G1 phase and reduces the cells in S phase and G2/M phase in 24 and 48 hours in the cultured endometriotic stromal cells. [3]

In vivo Dienogest (0.1-1 mg/kg per day, p.o.) reduces the endometrial implant volume to the same extent as Danazol (100 mg/kg per day, p.o.) in rats. Dienogest ameliorates the endometrial implant-induced alterations of the immune system: i.e. it increases the natural killer activity of peritoneal fluid cells and splenic cells, decreases the number of peritoneal fluid cells, and decreases interleukin-1beta production by peritoneal macrophages. Dienogest (0.1 mg/kg per day) combined with Buserelin (0.3 mg/kg per day) suppresses the bone mineral loss induced by buserelin alone, with no reduction of the effect on endometrial implants. [4]


Solubility (25°C)

In vitro DMSO 62 mg/mL (199.08 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 311.42


CAS No. 65928-58-7
Storage powder
in solvent
Synonyms STS 557

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Estrogen/progestogen Receptor Signaling Pathway Map

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