Bazedoxifene Acetate

For research use only.

Licensed by Pfizer Catalog No.S2167 Synonyms: WAY-140424, TSE-424

2 publications

Bazedoxifene Acetate Chemical Structure

Molecular Weight(MW): 530.65

Bazedoxifene Acetate (WAY-140424, TSE-424) is a third generation selective estrogen receptor modulator (SERM).

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Selleck's Bazedoxifene Acetate has been cited by 2 publications

1 Customer Review

  • J Med Chem 2014 57(3), 632-41. Bazedoxifene Acetate purchased from Selleck.

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description Bazedoxifene Acetate (WAY-140424, TSE-424) is a third generation selective estrogen receptor modulator (SERM).
estrogen receptor [1]
Methods Test Index PMID
Western blot
p-JAK1 / JAK1 / p-JAK2 / JAK2 / Cleaved caspase-3 / Bcl-2 / Survivin ; 

PubMed: 30648776     

Bazedoxifene inhibits signal transducer and activator of transcription (STAT)3 phosphorylation and expression of STAT3 downstream genes, and induces apoptosis. HEPG2 (A), 7721 (B) and HUH‐7 (C) cancer cell lines exhibit constitutively phosphorylated STAT3. Bazedoxifene (10, 15, 20, 25 μmol/L) inhibited the phosphorylation of STAT3 (Tyr 705), Janus kinase (JAK)1 and JAK2, induced apoptosis as evidenced by increased cleaved caspase‐3. The expression of STAT3‐mediated genes was decreased by bazedoxifene except for the expression of Bcl‐2 in 7721 cells. GAPDH, glyceraldehyde 3‐phosphate dehydrogenase.

p-STAT3 / STAT3 / p-AKT / p-ERK / Cleaved Caspase-3 ; 

PubMed: 28672024     

RH30, RD, and RH28 cells were treated with Bazedoxifene at the indicated concentration overnight. The protein expression of interest was determined by Western blot analysis with GAPDH as loading control. 

30648776 28672024
Growth inhibition assay
Cell viability; 

PubMed: 30648776     

HEPG2, HUH‐7 and 7721 liver cancer cells were treated with or without bazedoxifene (5, 10, 15, 20, 30 μmol/L) at 37°C for 24 h. Bazedoxifene inhibited cell viability (*P < 0.05). 




Solubility (25°C)

In vitro DMSO 100 mg/mL (188.44 mM)
Water Insoluble
Ethanol '25 mg/mL warmed

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Chemical Information

Molecular Weight 530.65


CAS No. 198481-33-3
Storage powder
in solvent
Synonyms WAY-140424, TSE-424
Smiles CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O.CC(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03475719 Unknown status Drug: HUG186-B and HUG186-D|Drug: HUG186 Osteoporosis Postmenopausal Huons Co. Ltd. January 11 2018 Phase 1
NCT03005340 Unknown status Drug: Treatment B|Drug: Treatment C|Drug: Treatment BC Healthy Alvogen Korea December 2016 Phase 1
NCT02448771 Active not recruiting Drug: Palbociclib|Drug: Bazedoxifene Breast Cancer Stage IV|Unresectable Locally Advanced Invasive Breast Cancer|Metastatic Invasive Breast Cancer Dana-Farber Cancer Institute|Pfizer July 7 2015 Phase 1|Phase 2
NCT01973738 Unknown status -- Selective Estrogen Receptor Modulator Toshihiko Kono|Tomidahama Hospital January 2012 --

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID