Catalog No. |
Product Name |
Information |
S1579 |
Palbociclib (PD0332991) Isethionate |
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. |
S2163 |
PF-4708671 |
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported. |
S1216 |
PFI-1 (PF-6405761) |
PFI-1 is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay. |
S2128 |
Bazedoxifene HCl |
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. |
S2224 |
UK 383367 |
UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs. |
S2222 |
PF-3716556 |
PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease. |
S2921 |
PF-4981517 |
PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. |
S2830 |
Clindamycin |
Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. |
S1036 |
PD0325901 |
PD0325901 is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2. |
S1039 |
Rapamycin (Sirolimus) |
Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells. |
S1068 |
Crizotinib (PF-02341066) |
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. |
S1116 |
Palbociclib (PD-0332991) HCl |
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. |
S1042 |
Sunitinib Malate |
Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. |
S1208 |
Doxorubicin (Adriamycin) HCl |
Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
S5001 |
Tofacitinib (CP-690550) Citrate |
Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. |
S1005 |
Axitinib |
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. |
S1044 |
Temsirolimus (CCI-779, NSC 683864) |
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. |
S1014 |
Bosutinib (SKI-606) |
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. |
S1264 |
PD173074 |
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. |
S1261 |
Celecoxib |
Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells. |
S2789 |
Tofacitinib (CP-690550,Tasocitinib) |
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. |
S2743 |
PF-04691502 |
PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. Phase 2. |
S1196 |
Exemestane |
Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. |
S1408 |
Linezolid |
Linezolid is a synthetic antibiotic used for the treatment of serious infections. |
S2077 |
Atorvastatin Calcium |
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. |
S1403 |
Tigecycline |
Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. |
S1331 |
Fluconazole |
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
S2777 |
PF-5274857 |
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
S2550 |
Tolterodine tartrate |
Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. |
S2666 |
PF-3845 |
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. |
S1444 |
Ziprasidone HCl |
Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
S1338 |
Gabapentin HCl |
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
S1440 |
Varenicline Tartrate |
Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction. |
S1508 |
Alprostadil |
Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist. |
S1727 |
Levonorgestrel |
Levonorgestrel is a female hormone that prevents ovulation. |
S1733 |
Methylprednisolone |
Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. |
S2717 |
CP-91149 |
CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose. |
S2133 |
Gabapentin |
Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
S2457 |
Clindamycin HCl |
Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. |
S2792 |
Torcetrapib |
Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3. |
S1835 |
Azithromycin |
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections. |
S1424 |
Prazosin HCl |
Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia. |
S1716 |
Glyburide (Glibenclamide) |
Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes. |
S1576 |
Sulfasalazine |
Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. |
S1808 |
Nifedipine |
Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina. |
S2551 |
Sulbactam sodium |
Sulbactam sodium (Unasyn) is an irreversible β-lactamase inhibitor. |
S2048 |
Clindamycin Phosphate |
Clindamycin Phosphate is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM. |
S4147 |
Azithromycin Dihydrate |
Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
S2167 |
Bazedoxifene Acetate |
Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM). |
S2596 |
Clindamycin palmitate HCl |
Clindamycin palmitate HCl is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid and a lincosamide antibiotic. |
S2589 |
Miglitol |
Miglitol is an oral anti-diabetic drug. |
S1958 |
Sulbactam |
Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM. |
S2118 |
Ibutilide Fumarate |
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |
Catalog No. |
Product Name |
Information |
S1036 |
PD0325901 |
PD0325901 is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2. |
S1039 |
Rapamycin (Sirolimus) |
Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells. |
S1068 |
Crizotinib (PF-02341066) |
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. |
S1116 |
Palbociclib (PD-0332991) HCl |
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. |
S1042 |
Sunitinib Malate |
Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. |
S1208 |
Doxorubicin (Adriamycin) HCl |
Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
S5001 |
Tofacitinib (CP-690550) Citrate |
Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. |
S1005 |
Axitinib |
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. |
S1044 |
Temsirolimus (CCI-779, NSC 683864) |
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. |
S1014 |
Bosutinib (SKI-606) |
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. |
S1264 |
PD173074 |
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. |
S1261 |
Celecoxib |
Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells. |
S2789 |
Tofacitinib (CP-690550,Tasocitinib) |
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. |
S2743 |
PF-04691502 |
PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. Phase 2. |
S1196 |
Exemestane |
Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. |
S1408 |
Linezolid |
Linezolid is a synthetic antibiotic used for the treatment of serious infections. |
S2077 |
Atorvastatin Calcium |
Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. |
S1403 |
Tigecycline |
Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. |
S1331 |
Fluconazole |
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
S2777 |
PF-5274857 |
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
S2550 |
Tolterodine tartrate |
Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. |
S2666 |
PF-3845 |
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. |
S1444 |
Ziprasidone HCl |
Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
S1338 |
Gabapentin HCl |
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
S1440 |
Varenicline Tartrate |
Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction. |
S1508 |
Alprostadil |
Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist. |
S1727 |
Levonorgestrel |
Levonorgestrel is a female hormone that prevents ovulation. |
S1733 |
Methylprednisolone |
Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. |
S2717 |
CP-91149 |
CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose. |
S2133 |
Gabapentin |
Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
S2457 |
Clindamycin HCl |
Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections. |
S2792 |
Torcetrapib |
Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3. |
S1835 |
Azithromycin |
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections. |
S1424 |
Prazosin HCl |
Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia. |
S1716 |
Glyburide (Glibenclamide) |
Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes. |
S1576 |
Sulfasalazine |
Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. |
S1808 |
Nifedipine |
Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina. |
S2551 |
Sulbactam sodium |
Sulbactam sodium (Unasyn) is an irreversible β-lactamase inhibitor. |
S2048 |
Clindamycin Phosphate |
Clindamycin Phosphate is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM. |
S4147 |
Azithromycin Dihydrate |
Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
S2167 |
Bazedoxifene Acetate |
Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM). |
S2596 |
Clindamycin palmitate HCl |
Clindamycin palmitate HCl is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid and a lincosamide antibiotic. |
S2589 |
Miglitol |
Miglitol is an oral anti-diabetic drug. |
S1958 |
Sulbactam |
Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM. |
S2118 |
Ibutilide Fumarate |
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |