Visomitin (SKQ1)

Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.

Visomitin (SKQ1) Chemical Structure

Visomitin (SKQ1) Chemical Structure

CAS: 934826-68-3

Purity & Quality Control

Batch: Purity: 98.17%
98.17

Visomitin (SKQ1) Related Products

Biological Activity

Description Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.
In vitro
In vitro

Visomitin (SKQ1) is a new type of mitochondrial-targeted antioxidant, which is expected to be used to treat inflammation related to ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 displays TC50 of 317 nM on HCjE cells.[1]

Cell Research Cell lines Human conjunctival epithelial (HCjE) and corneal epithelial (HCLE) cells
Concentrations 0.25 nM-250 μM
Incubation Time --
Method

The SkQ1 stock solution was serially diluted in culture medium, ranging from 0.25 nM to 250,000 nM, 10 × range. As a control, the diluent (50% ethanol) was also serially diluted in culture medium, ranging from 0 to 0.75%, equivalent to the concentrations carrying over from the SkQ1 stock. Cellular morphology changes were observed and recorded and transferred to a linked computer that ran Control My Nikon v3.0 software for further analysis. Quantitative cell viability was determined by MTT assay protocols established in the laboratory.

Chemical Information & Solubility

Molecular Weight 617.6 Formula

C36H42BrO2P

CAS No. 934826-68-3 SDF --
Smiles [Br-].CC1=C(C)C(=O)C(=CC1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Storage (From the date of receipt) 2 years -20°C liquid

In vitro
Batch:

DMSO : 100 mg/mL ( (161.91 mM); Warmed with 50°C water bath; Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : 3 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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