Catalog No.S8913

For research use only.

TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM.

TH5487 Chemical Structure

CAS No. 2304947-71-3

Selleck's TH5487 has been cited by 1 Publication

Purity & Quality Control

Choose Selective OGG1 Inhibitors

Biological Activity

Description TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM.
OGG1 [1]
(Cell-free assay)
342 nM
In vitro

TH5487 increases the melting temperature of OGG1 in human cells.TH5487 impaires repair of genomic 8-oxoG induced by KBrO3.TH5487 preventes OGG1 binding to its genomic substrate in living cells.[1]

In vivo

To assess whether TH5487 could down-regulate chemotactic (C-C and C-X-C) mediators in vivo, we challenge mouse lungs with TNFα and profile the gene expression of proinflammatory mediators. TH5487 is efficacious in vivo, suggesting that the compound could be used for the treatment of inflammatory conditions. [1]

Protocol (from reference)

Cell Research:


  • Cell lines: HEK 293T cells Wild-type, HEK 293T cells OGG1-KO, MLE12, hSAECs
  • Concentrations: 5 μM
  • Incubation Time: 1 h
  • Method:


Animal Research:


  • Animal Models: mice (50% female and 50% male) of which lungs are TNFα-challenged intranasally (20 ng/ml)
  • Dosages: 30 mg/kg
  • Administration: IP

Solubility (25°C)

In vitro

DMSO 10 mg/mL
(18.47 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 541.18


CAS No. 2304947-71-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCC1N2C3=C(C(=CC=C3)Br)NC2=O)C(=O)NC4=CC=C(C=C4)I

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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