Catalog No.S8944

For research use only.

G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.

G150 Chemical Structure

CAS No. 2369751-30-2

Purity & Quality Control

Choose Selective cGAS Inhibitors

Biological Activity

Description G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.
h-cGAS [1]
(Cell-free assay)
10.2 nM
In vitro

The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity[1].

Protocol (from reference)

Cell Research:


  • Cell lines: THP1 cells, primary macrophage cells
  • Concentrations: 10 μM and 5 μM
  • Incubation Time: 1 h
  • Method:

    Cellular activation of cGAS enzyme leads to IFNB1 mRNA expression in THP1, and primary human macrophage cells and is quantified using qRT-PCR. Total RNA is isolated from 5 × 105 THP1 cells per well of a 12-well plate, which are pre-incubated with G150 for 1 h. Human primary macrophages are used at 3×105 cells per well of a 12-well plate.

  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 78 mg/mL
(199.36 mM)
Ethanol 2 mg/mL
(5.11 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.25


CAS No. 2369751-30-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO

In vivo Formulation Calculator (Clear solution)

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mg/kg g μL

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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