G150

For research use only.

Catalog No.S8944

G150 Chemical Structure

Molecular Weight(MW): 391.25

G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM.

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Biological Activity

Description G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM.
Targets
h-cGAS [1]
(Cell-free assay)
10.2 nM
In vitro

The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity[1].

Protocol

Cell Research:

[1]

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  • Cell lines: THP1 cells, primary macrophage cells
  • Concentrations: 10 μM and 5 μM
  • Incubation Time: 1 h
  • Method:

    Cellular activation of cGAS enzyme leads to IFNB1 mRNA expression in THP1, and primary human macrophage cells and is quantified using qRT-PCR. Total RNA is isolated from 5 × 105 THP1 cells per well of a 12-well plate, which are pre-incubated with G150 for 1 h. Human primary macrophages are used at 3×105 cells per well of a 12-well plate.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.36 mM)
Ethanol 2 mg/mL (5.11 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.25
Formula

C18H16Cl2N4O2

CAS No. 2369751-30-2
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID