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S1P Receptor

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S1P Receptor Signaling Pathway

S1P Receptor Products

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  • S1P Receptor Inhibitors (5)
  • S1P Receptor Activators (3)
  • S1P Receptor Antagonists (5)
  • S1P Receptor Agonists (7)
  • S1P Receptor Modulators (3)
  • New S1P Receptor Products
Catalog No. Product Name Information Product Use Citations Product Validations
S5002 Fingolimod (FTY720) HCl Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
Nat Commun, 2025, 16(1):1826
Cell Commun Signal, 2025, 23(1):138
Chem Biol Interact, 2025, 417:111558
S7791 PMA (Phorbol 12-myristate 13-acetate) PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.
Protein Cell, 2025, pwaf020
iScience, 2025, 28(5):112379
Biomolecules, 2025, 15(4)572
S5950 Fingolimod (FTY-720) Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.
Nat Commun, 2024, 15(1):6970
Ther Adv Neurol Diso, 2024, 17:17562864241300047
Oncol Res, 2023, 31(6):867-875
S7179 Siponimod (BAF312) BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
Cell Death Dis, 2025, 16(1):282
Cancers (Basel), 2024, 16(3)574
J Neuroinflammation, 2023, 20(1):35
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
Cell Death Dis, 2025, 16(1):282
Front Pharmacol, 2024, 15:1494210
Cell Res, 2022, 10.1038/s41422-022-00614-0
S7952 Ozanimod Ozanimod is a selective oral S1P Receptor 1 modulator. Phase 3.
Nat Commun, 2025, 16(1):1826
Front Immunol, 2024, 15:1230735
Front Immunol, 2024, 15:1230735
S8241 Ponesimod Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
Cancers (Basel), 2024, 16(3)574
EBioMedicine, 2023, 94:104713
Int J Mol Sci, 2022, 23(18)10311
S6418 PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).
Cell Rep, 2023, 42(6):112586
Nat Commun, 2019, 11;10(1):4621
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Cell Death Discov, 2022, 8(1):48
Cell Death Discov, 2022, 8(1):48
S7180New SEW 2871 SEW2871 is an orally active, potent, and highly selective agonist of the sphingosine-1-phosphate type 1 receptor (S1P1) with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signalling pathways and induces S1P1 internalization and recycling.
Cell Death Dis, 2021, 12(11):1050
E2363 Etrasimod(APD334) Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.
E0482 MP-A08 MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SK1 and SK2.
E1917 SLF1081851 hydrochloride SLF1081851 hydrochloride is a potential inhibitor of Spns2 that blocks S1P release with an IC50 of 1.93 μM. It can be developed as a probe for studying Spns2 biology and immune modulation.
E1218 K6PC-5 K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.
Cell Prolif, 2024, e13604.
Int J Biol Sci, 2022, 18(7):2994-3005
E1123 K145 K145 is a selective, substrate-competitive and orally active sphingosine kinase-2 (SphK2) inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM in biochemical assays.
E1158 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM.
Cell Death Dis, 2025, 16(1):282
S6552 CYM5541 CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.
Brain Behav Immun, 2024, 124:205-217
E1999New Sphingosine-1-phosphate Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand toGPR3, GPR6 and GPR12. It enhances GPR3-, GPR6-, and GPR12-mediated intracellular Ca²⁺ mobilization and regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, adherens junction assembly, and morphogenesis.
S4462 CYM-5520 CYM-5520 is a highly selective sphingosine-1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 0.48 µM and does not activate other S1P receptors.
Front Pharmacol, 2024, 15:1494210
S3412 CYM50308 CYM50308 (ML248) is a potent and selective S1P4 receptor agonist with an EC50 of 56 nM.
E4956New Ozanimod hydrochloride Ozanimod hydrochloride(Zeposia, RPC-1063 HCL) is a potent sphingosine 1-phosphate (S1P)receptor modulator and a selective agonist of S1P receptor subtypes 1 (S1P1) and 5 (S1P5) with EC50's of 1.03 nM and 8.6 nM, respectively. It can be used in the trearment of relapsing multiple sclerosis (MS).
S7181New W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.
E2411 Taurodeoxycholic acid sodium hydrate Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
S6418 PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).
Cell Rep, 2023, 42(6):112586
Nat Commun, 2019, 11;10(1):4621
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Cell Death Discov, 2022, 8(1):48
Cell Death Discov, 2022, 8(1):48
E0482 MP-A08 MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SK1 and SK2.
E1917 SLF1081851 hydrochloride SLF1081851 hydrochloride is a potential inhibitor of Spns2 that blocks S1P release with an IC50 of 1.93 μM. It can be developed as a probe for studying Spns2 biology and immune modulation.
E1123 K145 K145 is a selective, substrate-competitive and orally active sphingosine kinase-2 (SphK2) inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM in biochemical assays.
S7791 PMA (Phorbol 12-myristate 13-acetate) PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.
Protein Cell, 2025, pwaf020
iScience, 2025, 28(5):112379
Biomolecules, 2025, 15(4)572
E1218 K6PC-5 K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.
Cell Prolif, 2024, e13604.
Int J Biol Sci, 2022, 18(7):2994-3005
E2411 Taurodeoxycholic acid sodium hydrate Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
S5002 Fingolimod (FTY720) HCl Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
Nat Commun, 2025, 16(1):1826
Cell Commun Signal, 2025, 23(1):138
Chem Biol Interact, 2025, 417:111558
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
Cell Death Dis, 2025, 16(1):282
Front Pharmacol, 2024, 15:1494210
Cell Res, 2022, 10.1038/s41422-022-00614-0
E2363 Etrasimod(APD334) Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.
E1158 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM.
Cell Death Dis, 2025, 16(1):282
S7181New W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.
S7179 Siponimod (BAF312) BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
Cell Death Dis, 2025, 16(1):282
Cancers (Basel), 2024, 16(3)574
J Neuroinflammation, 2023, 20(1):35
S7180New SEW 2871 SEW2871 is an orally active, potent, and highly selective agonist of the sphingosine-1-phosphate type 1 receptor (S1P1) with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signalling pathways and induces S1P1 internalization and recycling.
Cell Death Dis, 2021, 12(11):1050
S6552 CYM5541 CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.
Brain Behav Immun, 2024, 124:205-217
E1999New Sphingosine-1-phosphate Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand toGPR3, GPR6 and GPR12. It enhances GPR3-, GPR6-, and GPR12-mediated intracellular Ca²⁺ mobilization and regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, adherens junction assembly, and morphogenesis.
S4462 CYM-5520 CYM-5520 is a highly selective sphingosine-1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 0.48 µM and does not activate other S1P receptors.
Front Pharmacol, 2024, 15:1494210
S3412 CYM50308 CYM50308 (ML248) is a potent and selective S1P4 receptor agonist with an EC50 of 56 nM.
E4956New Ozanimod hydrochloride Ozanimod hydrochloride(Zeposia, RPC-1063 HCL) is a potent sphingosine 1-phosphate (S1P)receptor modulator and a selective agonist of S1P receptor subtypes 1 (S1P1) and 5 (S1P5) with EC50's of 1.03 nM and 8.6 nM, respectively. It can be used in the trearment of relapsing multiple sclerosis (MS).
S5950 Fingolimod (FTY-720) Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.
Nat Commun, 2024, 15(1):6970
Ther Adv Neurol Diso, 2024, 17:17562864241300047
Oncol Res, 2023, 31(6):867-875
S7952 Ozanimod Ozanimod is a selective oral S1P Receptor 1 modulator. Phase 3.
Nat Commun, 2025, 16(1):1826
Front Immunol, 2024, 15:1230735
Front Immunol, 2024, 15:1230735
S8241 Ponesimod Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
Cancers (Basel), 2024, 16(3)574
EBioMedicine, 2023, 94:104713
Int J Mol Sci, 2022, 23(18)10311
S7180New SEW 2871 SEW2871 is an orally active, potent, and highly selective agonist of the sphingosine-1-phosphate type 1 receptor (S1P1) with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signalling pathways and induces S1P1 internalization and recycling.
Cell Death Dis, 2021, 12(11):1050
E1999New Sphingosine-1-phosphate Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand toGPR3, GPR6 and GPR12. It enhances GPR3-, GPR6-, and GPR12-mediated intracellular Ca²⁺ mobilization and regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, adherens junction assembly, and morphogenesis.
E4956New Ozanimod hydrochloride Ozanimod hydrochloride(Zeposia, RPC-1063 HCL) is a potent sphingosine 1-phosphate (S1P)receptor modulator and a selective agonist of S1P receptor subtypes 1 (S1P1) and 5 (S1P5) with EC50's of 1.03 nM and 8.6 nM, respectively. It can be used in the trearment of relapsing multiple sclerosis (MS).
S7181New W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.

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