Home GPCR & G Protein S1P Receptor S1PR1 Selective Agonists | Modulators

S1PR1 Selective Agonists | Modulators

  • S1PR1
  • S1PR4
  • S1PR5
  • S1PR2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7952 Ozanimod Ozanimod is a selective oral S1P Receptor 1 modulator. Phase 3. Selective S1P1R, EC50: 0.41 nM
S8241 Ponesimod Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. Selective S1P1 receptor, EC50: 5.7 nM
S7179 Siponimod (BAF312) BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3. Pan S1P1 receptor, EC50: 0.39 nM