S1PR1 Selective Agonists | Modulators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7179 Siponimod (BAF312)

BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.

Pan S1P1 receptor, EC50: 0.39 nM
S7952 Ozanimod (RPC1063)

Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.

Selective S1P1R, EC50: 0.41 nM
S8241 Ponesimod

Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.

Selective S1P1 receptor, EC50: 5.7 nM