Catalog No.S1379 Synonyms: 13-cis retinoic acid

Isotretinoin Chemical Structure

Molecular Weight(MW): 300.44

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

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Biological Activity

Description It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
hydroxylase [1]
In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]

In vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]


Solubility (25°C)

In vitro DMSO 60 mg/mL (199.7 mM)
Water Insoluble
Ethanol Insoluble warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.44


CAS No. 4759-48-2
Storage powder
in solvent
Synonyms 13-cis retinoic acid

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03126916 Recruiting Childhood Ganglioneuroblastoma|Childhood Neuroblastoma|INRG Stage L2|INRG Stage M|INRG Stage MS|NMYC Gene Amplification|Recurrent Neuroblastoma Children''s Oncology Group|National Cancer Institute (NCI) May 9 2018 Phase 3
NCT03471455 Not yet recruiting Tinea Postgraduate Institute of Medical Education and Research April 2018 Phase 2
NCT03291080 Not yet recruiting Neuroblastoma Nova BioPharma Limited|Wellcome Trust|UK Department of Health January 1 2018 Phase 1|Phase 2
NCT03323801 Recruiting Male Infertility Azoospermia University of Washington July 25 2017 Phase 2
NCT03033303 Recruiting Neuroblastoma Memorial Sloan Kettering Cancer Center|Y-mAbs Therapeutics January 23 2017 Phase 2
NCT02795143 Recruiting Toxic Epidermal Necrolysis Massachusetts General Hospital November 2016 Not Applicable

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Hydroxylase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID