For research use only.

Catalog No.S1379 Synonyms: 13-cis retinoic acid

5 publications

Isotretinoin Chemical Structure

CAS No. 4759-48-2

Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Selleck's Isotretinoin has been cited by 5 publications

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Biological Activity

Description Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
hydroxylase [1]
In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]

In vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]


Solubility (25°C)

In vitro DMSO 60 mg/mL (199.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.44


CAS No. 4759-48-2
Storage powder
in solvent
Synonyms 13-cis retinoic acid
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03939364 Not yet recruiting Drug: SBS-101|Drug: Placebo Leukoplakia Oral Skyline Biosciences January 2022 Phase 1
NCT04594759 Active not recruiting Drug: Isotretinoin Acne Vulgaris Medical University of South Carolina November 11 2020 Phase 1|Phase 2
NCT04660916 Completed Drug: Isotretinoin Isotretinoin|Nail Abnormality Sinan Özçelik|Balikesir University October 22 2019 --
NCT04204304 Completed Drug: Isotretinoin Musculoskeletal Disease Other|Isotretinoin Adverse Reaction|Vitamin D Deficiency Ankara Training and Research Hospital March 15 2019 Not Applicable
NCT03323801 Completed Drug: 13-cis retinoic acid Male Infertility Azoospermia University of Washington July 25 2017 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID