Isotretinoin

Catalog No.S1379 Synonyms: 13-cis retinoic acid

Molecular Weight(MW): 300.44

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

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Biological Activity

Description

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Targets

hydroxylase ^[1]

In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. ^[1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. ^[2]

In vivo

Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. ^[1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. ^[3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. ^[4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. ^[5]

Protocol

References

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Solubility (25°C)

In vitro	DMSO	60 mg/mL (199.7 mM)
	Water	Insoluble
	Ethanol	Insoluble warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Isotretinoin SDF

Molecular Weight	300.44
Formula	C₂₀H₂₈O₂
CAS No.	4759-48-2
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	13-cis retinoic acid

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03126916	Recruiting	Childhood Ganglioneuroblastoma\|Childhood Neuroblastoma\|INRG Stage L2\|INRG Stage M\|INRG Stage MS\|NMYC Gene Amplification\|Recurrent Neuroblastoma	Children''s Oncology Group\|National Cancer Institute (NCI)	May 9 2018	Phase 3
NCT03471455	Not yet recruiting	Tinea	Postgraduate Institute of Medical Education and Research	April 2018	Phase 2
NCT03291080	Not yet recruiting	Neuroblastoma	Nova BioPharma Limited\|Wellcome Trust\|UK Department of Health	January 1 2018	Phase 1\|Phase 2
NCT03323801	Recruiting	Male Infertility Azoospermia	University of Washington	July 25 2017	Phase 2
NCT03033303	Recruiting	Neuroblastoma	Memorial Sloan Kettering Cancer Center\|Y-mAbs Therapeutics	January 23 2017	Phase 2
NCT02795143	Recruiting	Toxic Epidermal Necrolysis	Massachusetts General Hospital	November 2016	Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Hydroxylase Signaling Pathway Map

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