Isotretinoin

Catalog No.S1379 Synonyms: 13-cis retinoic acid

For research use only.

Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Isotretinoin Chemical Structure

CAS No. 4759-48-2

Selleck's Isotretinoin has been cited by 6 Publications

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Biological Activity

Description Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Targets
hydroxylase [1]
In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]

In vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 300.44
Formula

C20H28O2

CAS No. 4759-48-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03939364 Withdrawn Drug: SBS-101|Drug: Placebo Leukoplakia Oral Skyline Biosciences January 2022 Phase 1
NCT04594759 Active not recruiting Drug: Isotretinoin Acne Vulgaris Medical University of South Carolina November 11 2020 Phase 1|Phase 2
NCT04660916 Completed Drug: Isotretinoin Isotretinoin|Nail Abnormality Sinan Özçelik|Balikesir University October 22 2019 --
NCT04204304 Completed Drug: Isotretinoin Musculoskeletal Disease Other|Isotretinoin Adverse Reaction|Vitamin D Deficiency Ankara Training and Research Hospital March 15 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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