Catalog No.S1379 Synonyms: 13-cis retinoic acid
Molecular Weight(MW): 300.44
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
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|Description||It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.|
|In vivo||Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo.  Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats.  Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage.  Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. |
-  Webster WS, et al. J Craniofac Genet Dev Biol, 1986, 6(3), 211-222.
-  Smith-Thomas L, et al. Dev Biol, 1987, 123(1), 276-281.
-  Dopheide MM, et al. Pharmacol Biochem Behav, 2008, 91(2), 243-251.
|In vitro||DMSO||60 mg/mL (199.7 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||13-cis retinoic acid|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03126916||Recruiting||Childhood Ganglioneuroblastoma|Childhood Neuroblastoma|INRG Stage L2|INRG Stage M|INRG Stage MS|NMYC Gene Amplification|Recurrent Neuroblastoma||Children''s Oncology Group|National Cancer Institute (NCI)||May 9 2018||Phase 3|
|NCT03471455||Not yet recruiting||Tinea||Postgraduate Institute of Medical Education and Research||April 2018||Phase 2|
|NCT03291080||Not yet recruiting||Neuroblastoma||Nova BioPharma Limited|Wellcome Trust|UK Department of Health||January 1 2018||Phase 1|Phase 2|
|NCT03323801||Recruiting||Male Infertility Azoospermia||University of Washington||July 25 2017||Phase 2|
|NCT03033303||Recruiting||Neuroblastoma||Memorial Sloan Kettering Cancer Center|Y-mAbs Therapeutics||January 23 2017||Phase 2|
|NCT02795143||Recruiting||Toxic Epidermal Necrolysis||Massachusetts General Hospital||November 2016||Not Applicable|
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