Product Categories

COX Inhibitors

COX Inhibitors (26)
water-soluble

Cat.No.	Product Name	Information	Product Citations
S1261	Celecoxib	Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.	Blood, 2011, 118(22), 5891-5900
S2602	Acemetacin (Emflex)	Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
S3043	Rofecoxib (Vioxx)	Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM.
S2903	Lumiracoxib (COX-189)	Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with K_i of 0.06 μM.
S1328	Etodolac (Lodine)	Etodolac (Lodine) is a COX inhibitor with an IC50 of 53.5 nM.
S4078	Mefenamic Acid	Mefenamic acid is a competitive inhibitor of COX-1 and COX-2.
S4051	Nabumetone	Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S4049	Valdecoxib	Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
S4011	Ampiroxicam	Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
S1518	Ibuprofen Lysine (NeoProfen)	Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug.
S1645	Ketoprofen (Actron)	Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
S3023	Bufexamac	Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
S3008	Zaltoprofen	Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.
S2108	Flunixin meglumin	Flunixin meglumine is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.
S2121	Licofelone	Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
S2047	Lornoxicam (Xefo)	Lornoxicam (Xefo) is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.
S2040	Nimesulide	Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
S1959	Tolfenamic acid	Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM.
S2577	Phenacetin	Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
S3200	Triflusal	Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
S2531	Asaraldehyde (Asaronaldehyde)	Asaraldehyde (Asaronaldehyde) is natural COX-2 inhibitor.
S1903	Diclofenac	Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
S1713	Piroxicam (Feldene)	Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM.
S1626	Naproxen (Aleve)	Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
S1638	Ibuprofen (Advil)	Ibuprofen (Advil, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
S1646	Ketorolac (Toradol)	Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1261	Celecoxib	<1 mg/mL	76 mg/mL	33 mg/mL
S3043	Rofecoxib (Vioxx)	<1 mg/mL	63 mg/mL	<1 mg/mL
S2903	Lumiracoxib (COX-189)	<1 mg/mL	59 mg/mL	<1 mg/mL
S1328	Etodolac (Lodine)	<1 mg/mL	58 mg/mL	58 mg/mL
S4078	Mefenamic Acid	<1 mg/mL	48 mg/mL	<1 mg/mL
S4051	Nabumetone	<1 mg/mL	46 mg/mL	25 mg/mL
S4049	Valdecoxib	<1 mg/mL	63 mg/mL	18 mg/mL
S4011	Ampiroxicam	<1 mg/mL	90 mg/mL	<1 mg/mL
S1518	Ibuprofen Lysine (NeoProfen)	71 mg/mL	<1 mg/mL	<1 mg/mL
S1645	Ketoprofen (Actron)	<1 mg/mL	51 mg/mL	51 mg/mL
S3023	Bufexamac	<1 mg/mL	45 mg/mL	3 mg/mL
S3008	Zaltoprofen	<1 mg/mL	60 mg/mL	31 mg/mL
S2108	Flunixin meglumin	98 mg/mL	98 mg/mL	8 mg/mL
S2047	Lornoxicam (Xefo)	<1 mg/mL	2 mg/mL	<1 mg/mL
S2040	Nimesulide	<1 mg/mL	62 mg/mL	<1 mg/mL
S1959	Tolfenamic acid	<1 mg/mL	52 mg/mL	<1 mg/mL
S2577	Phenacetin	<1 mg/mL	36 mg/mL	36 mg/mL
S3200	Triflusal	<1 mg/mL	50 mg/mL	50 mg/mL
S2531	Asaraldehyde (Asaronaldehyde)	<1 mg/mL	39 mg/mL	16 mg/mL
S1903	Diclofenac	14 mg/mL	64 mg/mL	64 mg/mL
S1713	Piroxicam (Feldene)	<1 mg/mL	66 mg/mL	1 mg/mL
S1626	Naproxen (Aleve)	76 mg/mL	3 mg/mL	15 mg/mL
S1638	Ibuprofen (Advil)	<1 mg/mL	41 mg/mL	41 mg/mL
S1646	Ketorolac (Toradol)	75 mg/mL	75 mg/mL	75 mg/mL

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COX Inhibitors

COX Inhibitors (26)water-soluble

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COX Inhibitors (26)
water-soluble