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COX Inhibitors (40)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1261 Celecoxib Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
  • Blood, 2011, 118(22):5891-900
  • Br J Pharmacol, 2014, 171(2):498-508
  • J Cell Physiol, 2015, 230(5):1115-27
S1255 Nepafenac Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.
S1638 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
S1723 Indomethacin Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.
S2007 Sulindac Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.
  • Oncogene, 2016, 10.1038/onc.2016.247
S1634 Acetaminophen Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively.
S1734 Meloxicam Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
S3043 Rofecoxib Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.
  • Toxicol Appl Pharmacol, 2015, 285(1):51-60
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.
S4295 Meclofenamate Sodium Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.
S4248 Bromfenac Sodium Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
S1518 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
S1646 Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
S1903 Diclofenac Sodium Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.
  • Head Neck, 2014, 10.1002/hed.23822
S1328 Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
S1645 Ketoprofen Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
S1626 Naproxen Sodium Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
S1713 Piroxicam Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
S1960 Pranoprofen Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
S2602 Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
S2577 Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
S1959 Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.
S2040 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
  • Viruses, 2015, 7(5):2268-87
S2108 Flunixin Meglumin Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.
S3017 Aspirin Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
  • Toxicol Appl Pharmacol, 2015, 285(1):51-60
S3023 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
  • Nat Biotechnol, 2015, 10.1038/nbt.3130
S3018 Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
S4230 Oxaprozin Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
S2047 Lornoxicam Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
S3200 Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
S2903 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
  • xenobiotica, 2016, 10.1080/00498254.2016.1206239
S3008 Zaltoprofen Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.
S4011 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
S4049 Valdecoxib Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
  • Biochem Bioph Res Co, 2015, 460(2):198-204
S4051 Nabumetone Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S4078 Mefenamic Acid Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.
S4136 Carprofen Carprofen inhibits canine COX2 with IC50 of 30 nM.
S4149 Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.
S2531 Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
S1761 Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1261 Celecoxib <1 mg/mL 76 mg/mL 33 mg/mL
S1255 Nepafenac <1 mg/mL 50 mg/mL <1 mg/mL
S1638 Ibuprofen <1 mg/mL 41 mg/mL 41 mg/mL
S1723 Indomethacin <1 mg/mL 72 mg/mL 24 mg/mL
S2007 Sulindac <1 mg/mL 71 mg/mL 9 mg/mL
S1634 Acetaminophen 13 mg/mL 30 mg/mL 30 mg/mL
S1734 Meloxicam <1 mg/mL 30 mg/mL <1 mg/mL
S3043 Rofecoxib <1 mg/mL 63 mg/mL <1 mg/mL
S7889 Xanthohumol <1 mg/mL 70 mg/mL 70 mg/mL
S4295 Meclofenamate Sodium 63 mg/mL 63 mg/mL 63 mg/mL
S4248 Bromfenac Sodium 71 mg/mL 71 mg/mL 2 mg/mL
S1518 Ibuprofen Lysine 71 mg/mL <1 mg/mL <1 mg/mL
S1646 Ketorolac <1 mg/mL 75 mg/mL 75 mg/mL
S1903 Diclofenac Sodium 14 mg/mL 64 mg/mL 64 mg/mL
S1328 Etodolac <1 mg/mL 58 mg/mL 58 mg/mL
S1645 Ketoprofen <1 mg/mL 51 mg/mL 51 mg/mL
S1626 Naproxen Sodium 50 mg/mL 3 mg/mL <1 mg/mL
S1713 Piroxicam <1 mg/mL 66 mg/mL 1 mg/mL
S1960 Pranoprofen <1 mg/mL 51 mg/mL 6 mg/mL
S2602 Acemetacin <1 mg/mL 83 mg/mL 58 mg/mL
S2577 Phenacetin <1 mg/mL 36 mg/mL 36 mg/mL
S1959 Tolfenamic Acid <1 mg/mL 52 mg/mL <1 mg/mL
S2040 Nimesulide <1 mg/mL 62 mg/mL <1 mg/mL
S2108 Flunixin Meglumin 98 mg/mL 98 mg/mL 8 mg/mL
S3017 Aspirin <1 mg/mL 36 mg/mL 36 mg/mL
S3023 Bufexamac <1 mg/mL 45 mg/mL 3 mg/mL
S3018 Niflumic acid <1 mg/mL 56 mg/mL <1 mg/mL
S4230 Oxaprozin <1 mg/mL 59 mg/mL 27 mg/mL
S2047 Lornoxicam <1 mg/mL 3 mg/mL <1 mg/mL
S3200 Triflusal <1 mg/mL 50 mg/mL 50 mg/mL
S2903 Lumiracoxib <1 mg/mL 59 mg/mL <1 mg/mL
S3008 Zaltoprofen <1 mg/mL 60 mg/mL 31 mg/mL
S4011 Ampiroxicam <1 mg/mL 90 mg/mL <1 mg/mL
S4049 Valdecoxib <1 mg/mL 63 mg/mL 18 mg/mL
S4051 Nabumetone <1 mg/mL 46 mg/mL 25 mg/mL
S4078 Mefenamic Acid <1 mg/mL 48 mg/mL <1 mg/mL
S4136 Carprofen <1 mg/mL 55 mg/mL 55 mg/mL
S4149 Amfenac Sodium Monohydrate 59 mg/mL 59 mg/mL 4 mg/mL
S2531 Asaraldehyde <1 mg/mL 39 mg/mL 16 mg/mL
S1761 Suprofen <1 mg/mL 52 mg/mL 52 mg/mL
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