Dexamethasone Sodium Phosphate

Catalog No.S4028

Dexamethasone Sodium Phosphate Chemical Structure

Molecular Weight(MW): 516.4

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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2 Customer Reviews

  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone Sodium Phosphate purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone Sodium Phosphate purchased from Selleck.

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Biological Activity

Description Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Features Great selectivity for COX-2.
Targets
IL receptor [6] COX-2 [1]
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]

In vivo Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

Protocol

Animal Research:[5]
+ Expand
  • Animal Models: Sprague-Dawley rats
  • Formulation: Saline
  • Dosages: 100 μg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro Water 103 mg/mL (199.45 mM)
DMSO Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
Saline
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 516.4
Formula

C22H30FO8P.2Na

CAS No. 55203-24-2
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01236586 Withdrawn Lymphoma|Brain Neoplasms|Sarcoma|Osteosarcoma|Wilms Tumor National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 8, 2010 Phase 1
NCT03040011 Not yet recruiting Pelvic Organ Prolapse|Surgery|Postoperative Pain University of Pittsburgh|Magee-Womens Research Institute March 6, 2017 Phase 1|Phase 2
NCT01553214 Recruiting Blood Donor|Leukocyte Transfusion|Granulocyte Colony-Stimulation Factor|Blood Component Removal National Institutes of Health Clinical Center (CC) March 6, 2012 Phase 1
NCT02802163 Not yet recruiting Multiple Myeloma H. Lee Moffitt Cancer Center and Research Institute|Novartis|Amgen April 30, 2017 Phase 1|Phase 2
NCT02780609 Not yet recruiting Multiple Myeloma H. Lee Moffitt Cancer Center and Research Institute|Karyopharm Therapeutics, Inc April 30, 2017 Phase 1|Phase 2
NCT01660997 Withdrawn Multiple Myeloma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 30, 2012 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID