Catalog No.S2047 Synonyms: Chlortenoxicam
Molecular Weight(MW): 371.82
Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
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|Description||Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.|
Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. 
|In vivo||Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord.  Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats. |
|In vitro||DMSO||3 mg/mL warmed (8.06 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02750917||Completed||Postoperative Pain||Foisor Orthopedics Clinical Hospital||September 2014||Phase 3|
|NCT02025166||Unknown status||Pain||Rambam Health Care Campus||January 2014||--|
|NCT01480752||Completed||Post Operative Endodontic Pain||Islamic Azad University, Tehran||September 2011||Phase 2|
|NCT01069055||Unknown status||Inguinal Hernia|Postoperative Pain||Diskapi Teaching and Research Hospital||February 2010||Phase 3|
|NCT01117948||Terminated||Alzheimer´s Disease||JSW Lifesciences||September 2009||Phase 2|
|NCT01564680||Completed||Postoperative Pain||Dammam University||March 2009||Phase 4|
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