Resveratrol

Catalog No.S1396

Resveratrol Chemical Structure

Molecular Weight(MW): 228.24

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 310 In stock
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  • PC-9 and A549 cells were treated with 100 nM siRNA against PUMA and 100 nM negative control (NC) siRNA for 12 h, and treated with the indicated concentrations of RV and ERL in combination for an additional 48 h. The knockdown effects on PUMA were confirmed by Western blot analysis.

    Cell Physiol Biochem, 2015, 35: 2255-2271 . Resveratrol purchased from Selleck.

    Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.

    Dr. Johanna Weiss of University Hospital Heidelberg. Resveratrol purchased from Selleck.

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells MYjQdo9tcW[ncnH0bY9vKGG|c3H5 M3TselQ5KGh? MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjJ3ZT2wOUDPxE1? M4TW[VIyQDVzMEiz
human SK-N-SH cells MnXXVJJwdGmoZYLheIlwdiCjc4PhfS=> M3vo[lQ5KGh? M1jFW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utUk1UUCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUSuNFNmNTB3 MlnNNlE5PTFyOEO=
human A549 cells MXXQdo9tcW[ncnH0bY9vKGG|c3H5 NU\ubHB[PDhiaB?= MljpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:PC52N3WtNFU> MnTyNlE5PTFyOEO=
human MCF7 cells M{TSc3Bzd2yrZnXyZZRqd25iYYPzZZk> MWC0PEBp M2\TVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTdwOUHlMVA2 MYSyNVg2OTB6Mx?=
HEK293 cells NXPCdJpKTnWwY4Tpc44h[XO|YYm= MkWyOFghcA>? M{PiVWlvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3cXS7IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkG3N{DPxE1? MUCyNFUzPzh7MR?=
RAW264.7 cells NIXxUIdHfW6ldHnvckBie3OjeR?= NEj6cmVKdmirYnn0c5J6KGWoZnXjeEBwdiCSR1WtNkBxem:mdXP0bY9vKGmwIFzQV{1{fGmvdXzheIVlKFKDV{K2OE44KGOnbHzzMEBKSzVyPUSg{txO NUXLPYpbOTVyOEC5PFg>
mouse HT22 cells NEm2OYtHfW6ldHnvckBie3OjeR?= Ml;wNlQhcA>? MXrO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3i7dH;zbZMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> MYSyNVEzQTl5OB?=
human HL60 cell line M4PDVHBzd2yrZnXyZZRqd25iYYPzZZk> MlvzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGxibHnu[UwhUUN3ME21JO69VQ>? MoK1NVY3QDZ3NEO=
human Huh7.5.1 cells M{O4R2N6fG:2b4jpZ:Kh[XO|YYm= NY[1RWhPPzJiaB?= NVjEVmc{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWqNz61MlEh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwQVExNjZizszN MYSyN|Y4OzJ{NR?=
mouse Hepa1clc7 cells M2D3V2N6fG:2b4jpZ:Kh[XO|YYm= MUK3NkBp MnzFR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgTIVx[TGlbHO3JINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2xNUDPxE1? NWnWO4lUOTByN{W3OFI>
human H460 cells MVvQdo9tcW[ncnH0bY9vKGG|c3H5 NWLhRYszPzJiaB?= Ml\xRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKNE[wJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2xNk46KM7:TR?= MVeyNFQxQTd{Mx?=
human 293 cells M4Hqe2Z2dmO2aX;uJIF{e2G7 NVTjNZhrOjRiaB?= NW\NN|ZrUW6qaXLpeIlwdiCxZjDUUmZidHCqYTDpcoR2[2WmIF7GMYtieHCjQjDhZ5RqfmG2aX;uJIlvKGi3bXHuJFI6OyClZXzsd{Bi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVE3NjFizszN MlnoNVg1QDdyNUO=
human U937 cells NIO0SWREgXSxdH;4bYPDqGG|c3H5 MYK0PEBp NG\SVndEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBYW1RzIITld5QtKEmFNUC9NVch|ryP MVixOlI2Ojl{NB?=
human MCF7 cells NF;Wd2tHfW6ldHnvckBie3OjeR?= NIDQ[5U3KGh? MWjJcohq[mm2aX;uJI9nKHCqb4Lic4wh\XO2ZYKtbY5lfWOnZDDvdo5qfGirbnWg[IVk[XKkb4j5cIF{\SCrbjDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDZiaILzMEBKSzVyPUG5JO69VQ>? MnfwNVAxPzV5NEK=
HEK293T cells MXvGeY5kfGmxbjDhd5NigQ>? M37XfWlvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hUEWNMkmzWEBk\WyuczygTWM2OD1{MDFOwG0> NU\XflNCOTdzMkWyO|A>
human SW480 cells NHHVe4tRem:uaX\ldoF1cW:wIHHzd4F6 NWfQUZNOPDhiaB?= NXfIUoc5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUB2e2mwZzDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHHmeIVzKDR6IHjyd{whUUN3ME2yNEDPxE1? M2P6TlIxOzl3MEG5
human MDA-MB-231 cells MofMSpVv[3Srb36gZZN{[Xl? NV7rXVZJPiCmYYnz NUT3eWpESW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB4IHThfZMh[nliU2LCJIF{e2G7LDDJR|UxRTJyLkWg{txO M1nFVVIxPzJ6M{[5
human COLO205 cells MVTQdo9tcW[ncnH0bY9vKGG|c3H5 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEORTF:yNFUh[2WubIOgZpkhVVSWIHHzd4F6KCxiSVO1NF0zOy53IN88US=> MVeyOVQ2PTR6Nh?=
mouse NIH/3T3 cells NIixSHdEgXSxdH;4bYPDqGG|c3H5 NFq3Zmk6PiCq M{TqdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5KUC9|VEOgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zPC5{MjFOwG0> MoLWNlI4PDl|OUK=
human Caco-2 cells MkTrR5l1d3SxeHnjxsBie3OjeR?= Moq2N{Bl[Xm| NFjWPHVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxLUKgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfS=> MnTzNlA3Ojd|N{m=
human K562 cell line NYjVRotlWHKxbHnm[ZJifGmxbjDhd5NigQ>? MkTSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGxibHnu[UBmgHC{ZYPzbY5oKEKlcj3BZowtKEmFNUC9Nlgh|ryP NUPxdXg2OTZ4OE[1OFM>
MCF7 cells M{LTd2N6fG:2b4jpZ:Kh[XO|YYm= NGXGWoI4OiCq MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDld5Rzd2enbjDy[YNmeHSxcjDwc5NqfGm4ZTDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYpvwKwhUUN3ME2yPE4xPyEQvF2= NUnmbnpIOjN6NkC1PVA>
mouse 3T3L1 cells NVvyeXZ3TnWwY4Tpc44h[XO|YYm= MnTVO{Bl[Xm| NFL3[FdCdnSrYXTpdI9o\W6rYzDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKDOWM1yxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiZHnm[oVz\W62aXH0bY9vKGGodHXyJFch\GG7czDifUBwcWxvcnXkJG8he3SjaX7pcoctKEmFNUC9N|EvPCEQvF2= NVvuSYl[OTl5NUe4OVM>
human HeLa cells NVnscJdiTnWwY4Tpc44h[XO|YYm= Mn65N|AhdWmwcx?= MnH3TY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdicHH0bJdigSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiUF3BJIlv\HWlZXSgcJVkcW[ncnHz[UB1emWjdHXkJFMxKG2rboOgZoVnd3KnIHnu[JVkfGmxbh?= MorCNlM2PDd6NEO=
human HT144 cells MWPQdo9tcW[ncnH0bY9vKGG|c3H5 MlL4OUBl[Xm| NHWxT3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUNVQ1KGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDhZ4llKHCqb4PwbIF1[XOnIHHzd4F697zOIFnDOVA:PDBizszN M1HLZVE6PDhzNE[y
SKBR3 cells MmnHR5l1d3SxeHnjxsBie3OjeR?= MmXQO|IhcA>? NIH6XohEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBme3S{b3flckBz\WOncITvdkBv\WejdHn2[UBUU0KUMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F697zOIFnDOVA:PDFwNEKg{txO NWH1eZZZOjN6NkC1PVA>
human MGC803 cells NEDyeXJRem:uaX\ldoF1cW:wIHHzd4F6 M4PHXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVfDPFA{KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF01OiEQvF2= Mlj0NlU1PTV2OE[=
human MDA468 cells NYDr[WFZWHKxbHnm[ZJifGmxbjDhd5NigQ>? M13ucGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBOFY5KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF01PS5{IN88US=> MnzRNlU1PTV2OE[=
human HT-29 cells NGnnUGhEgXSxdH;4bYPDqGG|c3H5 NFTaRoM{KGSjeYO= NUP5dJFtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME20OU4{KM7:TR?= MWWyNFYzPzN5OR?=
human SK-MEL cells NWe0VVl5S3m2b4TvfIlkyqCjc4PhfS=> NUjpWVBDPDhiaB?= Mm\5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XoxvJygTWM2OD12Nz6zJO69VQ>? MlPlNlM2PDd6NEO=
human SH-SY5Y cells NXLJcYRjTnWwY4Tpc44h[XO|YYm= M37qWW5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gTFJQOi2rbnT1Z4VlKHKnZIXjeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjdDCxNEB2VSCjZoTldkAzPCCqcoOgZpkheGijc3WtZ49vfHKjc4SgcYlkem:pcnHwbEBidmGueYPpdy=> Mly3NlQzPjl3MUW=
HUVEC MoLISpVv[3Srb36gZZN{[Xl? Mn22NVAxKM7:TR?= MkD5NUBl[Xl? MnTzTY5lfWO2aX;uJI9nKG2rdH;jbI9v\HKrYXygZolw\2WwZYPpd{BqdiCKMl:yMYlv\HWlZXSgTHVXTUNiYYSgNVAxKHWvb3yvUEBxemW2cnXheIVlKG[xcjCxJIRigSCob3zsc5dm\CCkeTDjc41xd3WwZDD3ZZNpd3W2IHHu[EBJOk9{LYTy[YF1dWWwdDDt[YF{fXKnZDDh[pRmeiBzMDDkZZl{KGK7IF3peI9VemGla3XyJHJm\CC|dHHpcolv\y2kYYPl[EBie3OjeR?= NI\rNG0zOzh3OUK0PS=>
human SW480 cells MoPiR5l1d3SxeHnjxsBie3OjeR?= NX7jd25kOTBizszN NWHOZ3VjOiCmYYnz NFrBbnJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzR6MDDj[YxteyCjdDCxNEB2VSCob4KgNkBl[Xm|IHL5JJZqNWOnbHygZ4VtdCC4aXHibYxqfHliYX7hcJl{cXN? MWKyNVI6OTJ|NR?=
human LS 174T cells MnTXR5l1d3SxeHnjxsBie3OjeR?= NFz1cVMyOCEQvF2= NFHmUWI1KGSjeYO= MlHoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHMhOTd2VDDj[YxteyCjdDCxNEB2VSCob4KgOEBl[Xm|IHL5JJZqNWOnbHygZ4VtdCC4aXHibYxqfHliYX7hcJl{cXN? MYOyNVI6OTJ|NR?=
human CCD-18Co cells M1\ie2Z2dmO2aX;uJIF{e2G7 MUKxJO69VQ>? NE\JWJAyQCCq MlL2RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDDR2QuOTiFbzDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJGlNOWKndHGtbY5lfWOnZDDQS2UzKHC{b3T1Z5Rqd25iYYSgNUB2VSCjZoTldkAyQCCqcoO= NHvWSm4zODh4NkCzNi=>
mouse C2C12 cells NXm0OZZtTnWwY4Tpc44h[XO|YYm= NIDKNXY2OCEQvF2= NEXZPJEyPiCq MmjiTY5kemWjc3WgbY4hdWm2b3Poc45lemmjbDDmeY5kfGmxbjDpckBud3W|ZTDDNmMyOiClZXzsd{Bie3Onc4Pl[EBieyCnbnjhcoNmdWWwdDDv[kBucXSxY3jvcoRzcWGuIHTlcpNqfHliYYSgOVAhfU1iYX\0[ZIhOTZiaILzJIJ6KGe{ZXXuJGZOKGS7ZTDzeJJicW6rbnetZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7 NWXkUIpUOTl4NkO0PVg>
human H460 cells NFLMUmpHfW6ldHnvckBie3OjeR?= NVL2TmVtOjBizszN NEPVdnEzPCCq MVrD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDIOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOi:PIIDoZZNmKGG2IEKwJJVOKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\sc5ch[3m2b33leJJ6 MYGyNFQxQTd{Mx?=
mouse MC3T3-E1 cells NF6xXFBCeG:ydH;zbZMh[XO|YYm= Ml;oNUDPxE1? NXyx[G17PDhiaB?= MkDTTY5pcWKrdHnvckBw\iCjboTpZZBweHSxdHnjJIFkfGm4aYT5JIlvKG2xdYPlJG1EO1R|LVWxJINmdGy|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIlvKHC{ZYPlcoNmKG:oIFLNVFIue3CnY3nmbYMhdmW3dILhcIl7cW6pIHHueIljd2S7 NF7aeWwyPzVzM{i2Oy=>
human THP1 cells M1foNmZ2dmO2aX;uJIF{e2G7 MoToNVAxKM7:TR?= MnjqNUBp Mlm2TY5pcWKrdHnvckBw\iCIU1yxMYlv\HWlZXSgeZBz\We3bHH0bY9vKG:oIHTlZ5Rqdi1zIH3SUmEh\XiycnXzd4lwdiCrbjDpckBpfW2jbjDUTHAyKGOnbHzzJIF1KDFyMDD1UUBi\nSncjCxJIhzKGK7IGLUMXBEWg>? MX[xO|k{QDF6Nx?=
human T47D cells M3;JVnBzd2yrZnXyZZRqd25iYYPzZZk> MoLXNUDPxE1? NWXRWYVwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIF1KDFidV2gZpkh\myxdzDjfZRwdWW2com= M4rrblE4PTF|OE[3
human MG63 cells NU[zbG5GTnWwY4Tpc44h[XO|YYm= NEHzUJcxNjFidH:gNVAhfU1? MmjTO{Bl[Xm| M2XUdWlv[3KnYYPlJIlvKEGOUDDhZ5Rqfmm2eTDpckBpfW2jbjDNS|Y{KGOnbHzzJIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB5IHThfZM> NEXsS48yPzVzM{i2Oy=>
human U2OS cells NWLHfpg5TnWwY4Tpc44h[XO|YYm= MoHLNVAxKM7:TR?= NF3oTYNC[3SrdnH0bY9vKG:oIGPJVnQyKGmwIHj1cYFvKFV{T2OgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4heDV|IHTlZYNmfHmuYYTpc44hdGW4ZXygZZQhOTByIIXN NIPidnoyQDB2NkSwPS=>

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In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Human ovarian xenografts PA-1
  • Formulation: Solution in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01842399 Recruiting Vascular Resistance|Aging|Hypertension|Antioxidants|Aerobic Capacity National Institute on Aging (NIA)|National Institutes of Health Clinical Center (CC) February 9, 2013 Phase 1|Phase 2
NCT02905799 Not yet recruiting Primary Knee Osteoarthritis Assistance Publique - Hôpitaux de Paris|Unité de Recherche Clinique (URC) Paris Descartes Cochin January 2017 Phase 3
NCT02947932 Not yet recruiting Pancreatitis, Acute|Gastrointestinal Disease First Affiliated Hospital Xian Jiaotong University December 2016 Phase 4
NCT02998918 Recruiting Inflammation|Atherosclerosis|Cardiovascular Disease University of South Carolina September 2016 Phase 2
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT02523274 Recruiting Aging University of Florida June 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID