Resveratrol

Catalog No.S1396

Resveratrol Chemical Structure

Molecular Weight(MW): 228.24

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 310 In stock
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  • PC-9 and A549 cells were treated with 100 nM siRNA against PUMA and 100 nM negative control (NC) siRNA for 12 h, and treated with the indicated concentrations of RV and ERL in combination for an additional 48 h. The knockdown effects on PUMA were confirmed by Western blot analysis.

    Cell Physiol Biochem, 2015, 35: 2255-2271 . Resveratrol purchased from Selleck.

    Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.

    Dr. Johanna Weiss of University Hospital Heidelberg. Resveratrol purchased from Selleck.

Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Targets
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
In vitro

Resveratrol inhibits the activity of Cyclooxygenase and lipooxygenase, PKCs and p56lck, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of from 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism. [1] Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan. [2] Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells NWTXUJJ4WHKxbHnm[ZJifGmxbjDhd5NigQ>? NVrDWJBYPDhiaB?= NXvqUoVTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;Mj6yOYUuODVizszN NWLKd2ZEOjF6NUGwPFM>
human SK-N-SH cells MmjOVJJwdGmoZYLheIlwdiCjc4PhfS=> NIr1TIk1QCCq MnG2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3OMXNJKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND6wN4UuODV? M{PNS|IyQDVzMEiz
human A549 cells M3Lt[nBzd2yrZnXyZZRqd25iYYPzZZk> NH75cIg1QCCq NWDSeFJOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;ND60O4UuODV? NEnSdmkzOTh3MUC4Ny=>
human MCF7 cells M2nLd3Bzd2yrZnXyZZRqd25iYYPzZZk> MXK0PEBp MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF04NjlzZT2wOS=> NXeybmppOjF6NUGwPFM>
HEK293 cells MX3GeY5kfGmxbjDhd5NigQ>? NVPzSmlUPDhiaB?= MVXJcohq[mm2aX;uJI9nKFSQRj3hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4Tpeol1gSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5zN{Og{txO M1jINVIxPTJ5OEmx
RAW264.7 cells M2jBXWZ2dmO2aX;uJIF{e2G7 MmTGTY5pcWKrdH;yfUBm\m[nY4Sgc44hWEeHLUKgdJJw\HWldHnvckBqdiCOUGOtd5RqdXWuYYTl[EBTSVd{NkSuO{Bk\WyuczygTWM2OD12IN88US=> NGjSNngyPTB6MEm4PC=>
mouse HT22 cells MorQSpVv[3Srb36gZZN{[Xl? Mor2NlQhcA>? NWDjcXhFVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIH;4fZRwe2m|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? NYPm[WYyOjFzMkm5O|g>
human HL60 cell line M2r2THBzd2yrZnXyZZRqd25iYYPzZZk> M17vSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuIHzpcoUtKEmFNUC9OUDPxE1? NWLV[GRTOTZ4OE[1OFM>
human Huh7.5.1 cells M1TqNWN6fG:2b4jpZ:Kh[XO|YYm= M3zvbVczKGh? MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg4NjVwMTDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MUCuOkDPxE1? NV;Kd3dmOjN4N{OyNlU>
mouse Hepa1clc7 cells MVTDfZRwfG:6aXRCpIF{e2G7 M1XuTVczKGh? NX7JZXVqS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUGWyYUHjcIM4KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0yOSEQvF2= M4jablExODd3N{Sy
human H460 cells NFfISXdRem:uaX\ldoF1cW:wIHHzd4F6 MnSzO|IhcA>? M2L6NWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9NVIvQSEQvF2= NFK1dHgzODRyOUeyNy=>
human 293 cells NWHsWJJRTnWwY4Tpc44h[XO|YYm= NGDGTFkzPCCq M4LjVmlvcGmkaYTpc44hd2ZiVF7GZYxxcGFiaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjCyPVMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2xOk4yKM7:TR?= MYSxPFQ5PzB3Mx?=
human U937 cells MXnDfZRwfG:6aXRCpIF{e2G7 NXPsXol4PDhiaB?= NYfTVoJsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTl|NzDj[YxteyCjZoTldkA1QCCqcoOgZpkhX1OWMTD0[ZN1NCCLQ{WwQVE4KM7:TR?= NWTkR2xyOTZ{NUK5NlQ>
human MCF7 cells NI\XdXRHfW6ldHnvckBie3OjeR?= NF;HPHM3KGh? MmnDTY5pcWKrdHnvckBw\iCyaH;yZo9tKGW|dHXyMYlv\HWlZXSgc5JvcXSqaX7lJIRm[2G{Yn;4fYxie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB4IHjyd{whUUN3ME2xPUDPxE1? MlXBNVAxPzV5NEK=
HEK293T cells M2TkNmZ2dmO2aX;uJIF{e2G7 NFHxdmRKdmirYnn0bY9vKG:oIGTOSk1idHCqYT3pcoR2[2WmIF7GMYtieHCjQjDhZ5RqfmG2aX;uJIlvKEiHS{K5N3Qh[2WubIOsJGlEPTB;MkCg{txO MUSxO|EzPTJ5MB?=
human SW480 cells MkDyVJJwdGmoZYLheIlwdiCjc4PhfS=> NETFNmk1QCCq NGLTS3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JJV{cW6pIIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdiYX\0[ZIhPDhiaILzMEBKSzVyPUKwJO69VQ>? MnTqNlA{QTVyMUm=
human MDA-MB-231 cells M1P3SmZ2dmO2aX;uJIF{e2G7 M4jzOlYh\GG7cx?= NHu2U|RCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCVUlKgZZN{[XluIFnDOVA:OjBwNTFOwG0> NVv6SItmOjB5MkizOlk>
human COLO205 cells MWDQdo9tcW[ncnH0bY9vKGG|c3H5 M3XobmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1;MU|IxPSClZXzsd{BjgSCPVGSgZZN{[XliLDDJR|UxRTJ|LkWg{txO MYOyOVQ2PTR6Nh?=
mouse NIH/3T3 cells NFPCWXlEgXSxdH;4bYPDqGG|c3H5 NX;MXG5YQTZiaB?= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NlQvOjJizszN NF36ZXczOjd2OUO5Ni=>
human Caco-2 cells NWS0[lJnS3m2b4TvfIlkyqCjc4PhfS=> NIf4Opk{KGSjeYO= M1K1UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNi[29vMjDj[YxteyCjZoTldkA{KGSjeYOgZpkhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vKGG|c3H5 MVGyNFYzPzN5OR?=
human K562 cell line MYLQdo9tcW[ncnH0bY9vKGG|c3H5 Ml;nRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGxibHnu[UBmgHC{ZYPzbY5oKEKlcj3BZowtKEmFNUC9Nlgh|ryP NUfOTXdbOTZ4OE[1OFM>
MCF7 cells NWnvPGt[S3m2b4TvfIlkyqCjc4PhfS=> M4j4RlczKGh? MlXhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4KgdI9{cXSrdnWgUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H589yNKEmFNUC9NlgvODdizszN MVWyN|g3ODV7MB?=
mouse 3T3L1 cells M3;OcmZ2dmO2aX;uJIF{e2G7 MkiwO{Bl[Xm| NXHDV4FRSW62aXHkbZBw\2WwaXOgZYN1cX[rdImgZYdicW6|dDDtc5V{\SB|VEPMNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHTp[oZmemWwdHnheIlwdiCjZoTldkA4KGSjeYOgZpkhd2muLYLl[EBQKHO2YXnubY5oNCCLQ{WwQVMyNjRizszN MWWxPVc2Pzh3Mx?=
human HeLa cells NHHnW21HfW6ldHnvckBie3OjeR?= NXHJSHBKOzBibXnudy=> M3ftfmlvcGmkaYTpc44hd2ZiSHXk[4Vpd2dic3nncoFtcW6pIIDheIh4[XliaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGDNRUBqdmS3Y3XkJIx2[2moZYLhd4UhfHKnYYTl[EA{OCCvaX7zJIJm\m:{ZTDpcoR2[3Srb36= Ml3CNlM2PDd6NEO=
human HT144 cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 NEC5bnY2KGSjeYO= M2ryT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGSxOFQh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IHHjbYQheGixc4DoZZRie2ViYYPzZZnwxIxiSVO1NF01OCEQvF2= NYPSTZBXOTl2OEG0OlI>
SKBR3 cells M1G2ZWN6fG:2b4jpZ:Kh[XO|YYm= NF7pb3k4OiCq MlX0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4KgcoVo[XSrdnWgV2tDWjNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4Phfg+9lCCLQ{WwQVQyNjR{IN88US=> MWGyN|g3ODV7MB?=
human MGC803 cells NHf5c5dRem:uaX\ldoF1cW:wIHHzd4F6 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9OFIh|ryP MkTYNlU1PTV2OE[=
human MDA468 cells MnfHVJJwdGmoZYLheIlwdiCjc4PhfS=> MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQUS2PEBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9OFUvOiEQvF2= M2DKUVI2PDV3NEi2
human HT-29 cells MV3DfZRwfG:6aXRCpIF{e2G7 NHvPS3M{KGSjeYO= NX2ybIxHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFt|SG30bJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME20OU4{KM7:TR?= NX7ORY9SOjB4MkezO|k>
human SK-MEL cells MXzDfZRwfG:6aXRCpIF{e2G7 MUK0PEBp NUTlV2tFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0tvTVXMJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO|YYpvwKwhUUN3ME20O{4{KM7:TR?= MUeyN|U1Pzh2Mx?=
human SH-SY5Y cells M{HYZ2Z2dmO2aX;uJIF{e2G7 MVTO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIFiyU|IucW6mdXPl[EBz\WS3Y4Tpc44hd2ZiY3XscEB3cWGkaXzpeJkh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JJBp[XOnLXPvcpRz[XO2IH3pZ5Jw\3KjcHigZY5idHm|aYO= MnvKNlQzPjl3MUW=
HUVEC NHnFenBHfW6ldHnvckBie3OjeR?= M4L2cVExOCEQvF2= M4i0clEh\GG7 NHTG[2ZKdmS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEBjcW:pZX7ld4l{KGmwIFiyU|IucW6mdXPl[EBJXV[HQzDheEAyODBidX3vcE9NKHC{ZYTy[YF1\WRiZn;yJFEh\GG7IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgZY5lKEh{T{KteJJm[XSvZX70JI1m[XO3cnXkJIFnfGW{IEGwJIRigXNiYomgUYl1d1S{YXPr[ZIhWmWmIIP0ZYlvcW6pLXLhd4VlKGG|c3H5 MlL0NlM5PTl{NEm=
human SW480 cells MnnjR5l1d3SxeHnjxsBie3OjeR?= M1y5d|ExKM7:TR?= M2S5NFIh\GG7cx?= NUXvfYdwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d2OECgZ4VtdHNiYYSgNVAhfU1iZn;yJFIh\GG7czDifUB3cS2lZXzsJINmdGxidnnhZoltcXS7IHHuZYx6e2m| M3fuZVIyOjlzMkO1
human LS 174T cells NIT4PVZEgXSxdH;4bYPDqGG|c3H5 MkDpNVAh|ryP NEjKXJo1KGSjeYO= M4PWOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxUKDF5NGSgZ4VtdHNiYYSgNVAhfU1iZn;yJFQh\GG7czDifUB3cS2lZXzsJINmdGxidnnhZoltcXS7IHHuZYx6e2m| NVy0fYpLOjF{OUGyN|U>
human CCD-18Co cells NUDuOnRtTnWwY4Tpc44h[XO|YYm= NFTD[XEyKM7:TR?= NFfv[lIyQCCq NH3SbIpCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGNETC1zOFPvJINmdGy|IHHzd4V{e2WmIHnubIljcXSrb36gc4YhUUxzYnX0ZU1qdmS3Y3XkJHBITTJicILv[JVkfGmxbjDheEAyKHWPIHHmeIVzKDF6IHjydy=> MnjKNlA5PjZyM{K=
mouse C2C12 cells NFHQZotHfW6ldHnvckBie3OjeR?= MXq1NEDPxE1? NEK5OXgyPiCq M3;jcGlv[3KnYYPlJIlvKG2rdH;jbI9v\HKrYXyg[pVv[3Srb36gbY4hdW:3c3WgR|JEOTJiY3XscJMh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgc4YhdWm2b3Poc45lemmjbDDk[Y5{cXS7IHH0JFUxKHWPIHHmeIVzKDF4IHjyd{BjgSCpcnXlckBHVSCmeXWgd5Rz[WmwaX7nMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeR?= MWKxPVY3OzR7OB?=
human H460 cells M3LpUGZ2dmO2aX;uJIF{e2G7 MoDsNlAh|ryP M4exdVI1KGh? MWrD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDIOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOi:PIIDoZZNmKGG2IEKwJJVOKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\sc5ch[3m2b33leJJ6 NH;Sc4kzODRyOUeyNy=>
mouse MC3T3-E1 cells NIjkOGtCeG:ydH;zbZMh[XO|YYm= NWfoR4JLOSEQvF2= MlHlOFghcA>? NEL5SWNKdmirYnn0bY9vKG:oIHHueIlieG:ydH;0bYMh[WO2aY\peJkhcW5ibX;1d4UhVUN|VEOtSVEh[2WubIOgZZQhOSC3TTDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gRm1ROi2|cHXjbYZq[yCwZYX0doFtcXqrbnegZY51cWKxZIm= NX3lfWVIOTd3MUO4Olc>
human THP1 cells NVnEVVNjTnWwY4Tpc44h[XO|YYm= MWWxNFAh|ryP NGjFbWEyKGh? NHrSdVFKdmirYnn0bY9vKG:oIF\TUFEucW6mdXPl[EB2eHKnZ4XsZZRqd25ib3[g[IVkfGmwLUGgcXJPSSCneIDy[ZN{cW:wIHnuJIlvKGi3bXHuJHRJWDFiY3XscJMh[XRiMUCwJJVOKGGodHXyJFEhcHJiYomgVnQuWEOU MWGxO|k{QDF6Nx?=
human T47D cells NUO0PIF6WHKxbHnm[ZJifGmxbjDhd5NigQ>? MlHGNUDPxE1? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFR2N1SgZ4VtdHNiYYSgNUB2VSCkeTDmcI94KGO7dH;t[ZRzgQ>? MXixO|UyOzh4Nx?=
human MG63 cells NWD5PJF7TnWwY4Tpc44h[XO|YYm= NEXQSIMxNjFidH:gNVAhfU1? M2TSclch\GG7cx?= NEPHNo5KdmO{ZXHz[UBqdiCDTGCgZYN1cX[rdImgbY4hcHWvYX6gUWc3OyClZXzsd{BifCByLkGgeI8hOTBidV2gZYZ1\XJiNzDkZZl{ MUWxO|UyOzh4Nx?=
human U2OS cells NYDlNop{TnWwY4Tpc44h[XO|YYm= NYT4W25iOTByIN88US=> M{jMbmFkfGm4YYTpc44hd2ZiU1nSWFEhcW5iaIXtZY4hXTKRUzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBxPTNiZHXhZ4V1gWyjdHnvckBt\X[nbDDheEAyODBidV2= NGPN[|gyQDB2NkSwPS=>

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In vivo Resveratrol improves health and survival of mice on a high-calorie diet. Resveratrol (22.4 mg/kg/day) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α) activity, increased mitochondrial number, and improved motor function. Resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. [3] Resveratrol has been shown to inhibit the initiation and growth of tumors in a wide variety of rodent cancer models. Dose of Resveratrol as low as 200 μg/kg daily already shows efficacy in a rat model of colon carcinogenesis. At higher dose of 40 mg/kg, Resveratrol increases the survival of mice with subcutaneous neuroblastomas from 0% to 70%. Resveratrol inhibits vascularization in the corneal micropocket assay in mice at a dose of only 48 μg/kg when administered daily. [3] Resveratrol shows beneficial effects on heart disease. Resveratrol blocks the increase in platelet aggregation induced by a hypercholesterolaemic diet. Resveratrol increase expression of both endothelial and inducible nitric oxide synthase. In stroke-prone, spontaneously hypertensive rats, resveratrol significantly reduces markers of oxidative stress such as glycated albumin in serum, and 8-hydroxyguanos-ine in urine. Providing Resveratrol in drinking water for 15 days (1 mg/kg) is sufficient to improve the recovery in function and coronary flow of isolated hearts. [3] Resveratrol displays anti-inflammatory activity in vivo. Resveratrol significantly reduces both acute and chronic chemically induced oedema, lipopolysaccharide-induced airway inflammation and osteoarthritis, and helps to prevent allograft rejection. Intravenously administered Resveratrol decreases inflammation induced by ischaemia/reperfusion, oxidants generated by hypoxanthine/xanthine oxidase (HX/XO) or platelet-activating factor, but not leukotriene B4 in rats. [3] Resveratrol shows beneficial effects on stroke and brain damage. Resveratrol administered intravenously significantly decreased ischaemic volume and brain water content at the extremely low doses of 100 ng/kg and 1 μg/kg after middle cerebral artery occlusion in rats. [5]

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: Human breast cancer cell MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2 days
  • Method:

    Cells are plated in flat-bottomed, 96-well microtiter plates (4000 cells/6.4-mm-diameter well). After 12–24 hr, cells are treated with DMSO (0.1–0.3%) or increasing doses of Resveratrol. After 48 h of treatment, cells are treated with 10μL of MTT reagent for 4 hr at 37 ℃ and then treated with 100 μL of solubilization solution at 37 ℃ overnight. The quantity of formazan product is measured using a spectrophotometric microtiter plate reader at 570 nm wavelength.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Human ovarian xenografts PA-1
  • Formulation: Solution in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 100 mg/kg
  • Administration: i.p. daily for consecutive 4 weeks
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 501-36-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01842399 Recruiting Vascular Resistance|Aging|Hypertension|Antioxidants|Aerobic Capacity National Institute on Aging (NIA)|National Institutes of Health Clinical Center (CC) February 9, 2013 Phase 1|Phase 2
NCT02905799 Not yet recruiting Primary Knee Osteoarthritis Assistance Publique - Hôpitaux de Paris|Unité de Recherche Clinique (URC) Paris Descartes Cochin January 2017 Phase 3
NCT02947932 Not yet recruiting Pancreatitis, Acute|Gastrointestinal Disease First Affiliated Hospital Xian Jiaotong University December 2016 Phase 4
NCT02998918 Recruiting Inflammation|Atherosclerosis|Cardiovascular Disease University of South Carolina September 2016 Phase 2
NCT02909686 Recruiting Gulf War Illness University of Alabama at Birmingham|Congressionally Directed Medical Research Programs July 2016 Phase 2
NCT02523274 Recruiting Aging University of Florida June 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID