Resveratrol Chemical Structure
A selective activator of human SIRT1
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM.
AZD1152 is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM.
HSP-70 Inducer
LBH589 (Panobinostat) is a HDAC inhibitor, IC50 for inhibition of proliferation in MOLT-4 cells is approximately 5 μM and for Reh cells is approximately 20 μM.
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively.
Inhibitor of HDAC, HDAC inhibitory activity of TSA was similar in all cell lines with mean ± SD IC50 of 2.4 ± 0.5 nm (range, 1.5–2.9 nm)
Vorinostat also known as SAHA, Zolinza, MK-0683 is an HDAC inhibitor. Vorinostat CAS No 149647-78-9 with purity >99% & solubility DMSO is available.
VX-680 (MK-0457, Tozasertib) is the inhibitor of Aurora-A,-B,-C kinases with apparent inhibition constant values of 0.6,18,4.6 nM respectively.
NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor to HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.
Resveratrol is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. The effects of resveratrol on the lifespan of many model organisms remain controversial, with uncertain effects in fruit flies, nematode worms, and short-lived fish. In mouse and rat experiments, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported. Most of these results have yet to be replicated in humans. [1]
| Molecular Weight (WM): | 228.24 |
|---|---|
| Formula: | C14H12O3 |
| CAS No.: | 501-36-0 |
| Synonyms: |
N/A
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| Dissolve in (25°C): | DMSO ≥46mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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