Bromfenac Sodium

Catalog No.S4248 Synonyms: AHR 10282R

Bromfenac Sodium Chemical Structure

Molecular Weight(MW): 356.15

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

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Biological Activity

Description Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
Targets
COX1 [1] COX-2 [1]
In vivo Bromfenac (bromfenac sodium) by the oral route at pretreatment times of 10 min, 20 min and 300 min is respectively 3.7, 6.5 and 2.9 times more potent than zomepirac and 3.4, 6.6, and 44.2 times more potent than suprofen in the acetylcholine abdominal constriction assay in mice. Bromfenac when given orally is 5.8 times more potent than zomepirac in blocking the nociceptive response to bradykinin in dogs. Bromfenac is 6.1 to 32.8 times more potent than indometacin in inhibiting the formation of prostaglandin E2 and F2 alpha from microsomes of bovine seminal vesicles, rabbit uteri, and rabbit renal medullae. Bromfenac, given orally, is more potent than indometacin in suppressing acute (7.5-20 times) and chronic (3.8 times) inflammation in mice. [1] Bromfenac (1 mg/kg, i.v.) is metabolited into an unusual conjugate, bromfenac N-glucoside, in rats bile. [2] Bromfenac shows a rapid onset of activity (20 min) that persisted for at least 4 hours in a mouse model of pain (acetylcholine abdominal constriction). Bromfenac (0.316 mg/kg) produces significant anti-inflammatory activity up to 24 hours after dosing in a rat model of inflammation (carrageenan foot edema). Bromfenac is readily absorbed after oral administration, peak plasma levels being achieved at the earliest time tested: 20 min in the mouse and 30 min in the rat. [3]

Protocol

Solubility (25°C)

In vitro DMSO 71 mg/mL (199.35 mM)
Water 71 mg/mL (199.35 mM)
Ethanol 2 mg/mL (5.61 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.15
Formula

C15H11BrNO3.Na

CAS No. 91714-93-1
Storage powder
Synonyms AHR 10282R

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02681679 Completed Cataract Sun Yat-sen University|Ministry of Health, China October 2014 --
NCT02361645 Completed Vitreous Inflammation Università degli Studi di Brescia March 2014 Phase 3
NCT02137161 Completed Cataract|Pseudoexfoliation Syndrome Arcispedale Santa Maria Nuova-IRCCS November 2013 Phase 4
NCT01774474 Recruiting Cystoid Macular Edema|Cataract|Diabetes Mellitus Maastricht University Medical Center|European Society of Cataract and Refractive Surgeons July 2013 Phase 3
NCT01847638 Recruiting Cataract|Retinal Edema|Inflammation Melissa Toyos, MD|Bausch & Lomb Incorporated|Discover Vision Centers April 2013 --
NCT01475877 Completed Myopia Virdi Eye Clinic May 2011 Phase 4

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