Home Neuronal Signaling COX inhibitor Fenbufen For research use only.

Fenbufen

Synonyms: Lederfen, CL-82204

Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.

Fenbufen Chemical Structure

Fenbufen Chemical Structure

CAS: 36330-85-5

Selleck's Fenbufen has been cited by 1 publication

Purity & Quality Control

Batch: S452601 DMSO] 50 mg/mL] false] Ethanol] 50 mg/mL] false] Water] Insoluble] false Purity: 99.01%
99.01

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Signaling Pathway

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Biological Activity

Description Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.
Targets
cyclo-oxygenase [3] ATP systhesis [1]
0.88 μM(Ki)
In Vivo
In vivo Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].

Chemical Information & Solubility

Molecular Weight 254.28 Formula

C16H14O3
CAS No. 36330-85-5 SDF Download Fenbufen SDF
Smiles C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (196.63 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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