Catalog No.S3017 Synonyms: Acetylsalicylic acid

Aspirin Chemical Structure

Molecular Weight(MW): 180.16

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 470 In stock
USD 990 In stock
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Biological Activity

Description Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
COX2 [1] COX1 [1]
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human AGS cells NEPORlRHfW6ldHnvckBie3OjeR?= MYqxOU03OCEQvH3vcE9N M2PiSlEzKGh? NYWwSHk6UW6qaXLpeIlwdiCxZjDFd4Np\XKrY3jpZUBkd2yrLYP0bY12dGG2ZXSgTWwuQCCycn;keYN1cW:wIHnuJIh2dWGwIFHHV{Bk\WyuczDheEAyPSC2bzC2NEB2dW:uL1ygZYZ1\XJiMUKgbJJ{KGK7IFXMTXNC MWqyNFE2OzF6Mx?=
human PC3 cells NGm5b3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\pNWU{ODBizszN NXXZbIl{PDhiaB?= M4jEdGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{BifCB|MECgeW0h[W[2ZYKgOFghcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 NFHK[GgzOjR7NE[xOy=>
human HCT116 cells NHTiWYJHfW6ldHnvckBie3OjeR?= M2fXRVEhdU1? NVLWTVlXPiCq M1zJd2lvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiTl[tb4FxeGGEIHHjeIl3[XSrb36gbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGG2IEGgcW0h[W[2ZYKgOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 NHz5bHIzOjF3NEizOC=>
human THP1 cells NFHJOm5HfW6ldHnvckBie3OjeR?= NEnNPFkyODBizszN Ml;oN|AhdWmwcx?= MnLYTZJz\X[ncoPpZoxmKGmwaHnibZRqd25ib3[gR29ZNTFiaX6gbJVu[W5iVFjQNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHHyZYNpcWSxbnnjJIFkcWRvaX7keYNm\CCWWFKyJIZwem2jdHnvckBifCBzMECgeW0hcW6ldXLheIVlKG[xcjCzNEBucW6|IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgcYVie3W{ZXSgN|AhdWmwczDwc5N1KGG{YXPobYRwdmmlIHHjbYQh[2ijbHzlcodmKGK7IILh[IlwcW2vdX7vZZN{[Xl? NVnFTG9oOjN4NUGzOVk>
human PANC1 cells NEXkU25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEnifGw{ODBizszN NWGwbVlsPDhiaB?= NWf4UpZ3T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEGQQ{GgZ4VtdHNiYYSgN|AxKHWPIHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigQ>? M1nRN|IzPDl2NkG3
human SKBR3 cells NITBO4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYD0RVdPOzByIN88US=> NILENYI1QCCq NWrP[XJwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0uEUkOgZ4VtdHNiYYSgN|AxKHWPIHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigQ>? MVeyNlQ6PDZzNx?=
human MDA-MB-231 cells MUPGeY5kfGmxbjDhd5NigQ>? NVPpZo5{OTByIN88US=> MmXyN|AhdWmwcx?= NXzGbm1YUXK{ZY\ldpNq[mynIHnubIljcXSrb36gc4YhS0:[LUGgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHHyZYNpcWSxbnnjJIFkcWRvaX7keYNm\CCSR1WyJIZwem2jdHnvckBifCBzMECgeW0hcW6ldXLheIVlKG[xcjCzNEBucW6|IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgcYVie3W{ZXSgN|AhdWmwczDwc5N1KGG{YXPobYRwdmmlIHHjbYQh[2ijbHzlcodmKGK7IILh[IlwcW2vdX7vZZN{[Xl? Mkn6NlM3PTF|NUm=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 36 mg/mL (199.82 mM)
Ethanol 36 mg/mL (199.82 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.16


CAS No. 50-78-2
Storage powder
in solvent
Synonyms Acetylsalicylic acid

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02007837 Not yet recruiting Pregnancy Induced Hypertension UMC Utrecht|Ghana Health Services|University of Ghana January 2018 Phase 3
NCT02735902 Not yet recruiting Transcatheter Aortic Valve Replacement Centre Hospitalier Universitaire de Nīmes|Medtronic April 2017 Phase 4
NCT02797548 Not yet recruiting Antiplatelet Drugs Seung-Jung Park|CardioVascular Research Foundation, Korea|Asan Medical Center March 2017 Phase 4
NCT02666742 Not yet recruiting Ventricular Tachycardia Dhanunjaya Lakkireddy, MD, FACC|Bristol-Myers Squibb|University of Kansas Medical Center February 2017 Phase 4
NCT03023020 Not yet recruiting High Bleeding Risk|Coronary Artery Disease|PCI ECRI bv|Cardialysis B.V.|European Cardiovascular Research Center|University of Bern|Terumo Medical Corporation February 2017 --
NCT02984384 Not yet recruiting Blood Clot|Trauma Major Extremity Trauma Research Consortium|Patient-Centered Outcomes Research Institute February 2017 Phase 3

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID