Catalog No.S3017 Synonyms: Acetylsalicylic acid

Aspirin Chemical Structure

Molecular Weight(MW): 180.16

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 470 In stock
USD 990 In stock
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Biological Activity

Description Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
COX2 [1] COX1 [1]
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human AGS cells MYfGeY5kfGmxbjDhd5NigQ>? NYjHXHl{OTVvNkCg{txud2xxTB?= NU\o[WlROTJiaB?= MXPJcohq[mm2aX;uJI9nKEW|Y3jldolkcGmjIHPvcIkue3SrbYXsZZRm\CCLTD24JJBzd2S3Y4Tpc44hcW5iaIXtZY4hSUeVIHPlcIx{KGG2IEG1JJRwKDZyIIXtc4wwVCCjZoTldkAyOiCqcoOgZpkhTUyLU1G= NUfRW2E5OjBzNUOxPFM>
human PC3 cells MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4my[FMxOCEQvF2= NUTr[ppFPDhiaB?= MWHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZZQhOzByIIXNJIFnfGW{IES4JIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeR?= MkPuNlI1QTR4MUe=
human HCT116 cells MV;GeY5kfGmxbjDhd5NigQ>? M{O3flEhdU1? MUW2JIg> MmLrTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMTDtUUBi\nSncjC2JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> NITjbFAzOjF3NEizOC=>
human THP1 cells NYHGWmN4TnWwY4Tpc44h[XO|YYm= MXuxNFAh|ryP MmfIN|AhdWmwcx?= NHz5c5RKenKndnXyd4ljdGViaX7obYJqfGmxbjDv[kBEV1hvMTDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZZJi[2irZH;ubYMh[WOrZD3pcoR2[2WmIGTYRlIh\m:{bXH0bY9vKGG2IEGwNEB2VSCrbnP1ZoF1\WRiZn;yJFMxKG2rboOg[o9tdG:5ZXSgZpkh[2:vcH;1coQhf2G|aH;1eEBu\WG|dYLl[EA{OCCvaX7zJJBwe3RiYYLhZ4hq\G:waXOgZYNq\CClaHHscIVv\2ViYomgdoFlcW:rbX31co9ie3OjeR?= MoLnNlM3PTF|NUm=
human PANC1 cells NYfyNHVZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIj2SFg{ODBizszN MX[0PEBp NHvXNZRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSU6FMTDj[YxteyCjdDCzNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6 MViyNlQ6PDZzNx?=
human SKBR3 cells NYHwZ2xET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmS1N|AxKM7:TR?= NXzUTZFjPDhiaB?= NFmyPFRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUU0KUMzDj[YxteyCjdDCzNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6 M17hZ|IzPDl2NkG3
human MDA-MB-231 cells MXnGeY5kfGmxbjDhd5NigQ>? Mnu3NVAxKM7:TR?= MVyzNEBucW6| NFfaWXJKenKndnXyd4ljdGViaX7obYJqfGmxbjDv[kBEV1hvMTDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYYLhZ4hq\G:waXOgZYNq\C2rbnT1Z4VlKFCJRUKg[o9zdWG2aX;uJIF1KDFyMDD1UUBqdmO3YnH0[YQh\m:{IEOwJI1qdnNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDt[YF{fXKnZDCzNEBucW6|IIDvd5Qh[XKjY3jp[I9vcWNiYXPp[EBkcGGubHXu[4Uh[nlicnHkbY9qdW23bn;hd5NigQ>? MUOyN|Y2OTN3OR?=

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Solubility (25°C)

In vitro DMSO 36 mg/mL (199.82 mM)
Ethanol 36 mg/mL (199.82 mM)
Water Insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.16


CAS No. 50-78-2
Storage powder
Synonyms Acetylsalicylic acid

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02007837 Not yet recruiting Pregnancy Induced Hypertension UMC Utrecht|Ghana Health Services|University of Ghana January 2018 Phase 3
NCT02735902 Not yet recruiting Transcatheter Aortic Valve Replacement Centre Hospitalier Universitaire de Nīmes|Medtronic April 2017 Phase 4
NCT02797548 Not yet recruiting Antiplatelet Drugs Seung-Jung Park|CardioVascular Research Foundation, Korea|Asan Medical Center March 2017 Phase 4
NCT02666742 Not yet recruiting Ventricular Tachycardia Dhanunjaya Lakkireddy, MD, FACC|Bristol-Myers Squibb|University of Kansas Medical Center February 2017 Phase 4
NCT03023020 Not yet recruiting High Bleeding Risk|Coronary Artery Disease|PCI ECRI bv|Cardialysis B.V.|European Cardiovascular Research Center|University of Bern|Terumo Medical Corporation February 2017 --
NCT02984384 Not yet recruiting Blood Clot|Trauma Major Extremity Trauma Research Consortium|Patient-Centered Outcomes Research Institute February 2017 Phase 3

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID