Aspirin

Catalog No.S3017 Synonyms: Acetylsalicylic acid

Aspirin Chemical Structure

Molecular Weight(MW): 180.16

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 470 In stock
USD 990 In stock
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Purity & Quality Control

Choose Selective COX Inhibitors

Biological Activity

Description Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Targets
COX2 [1] COX1 [1]
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human AGS cells MYfGeY5kfGmxbjDhd5NigQ>? NYjHXHl{OTVvNkCg{txud2xxTB?= NU\o[WlROTJiaB?= MXPJcohq[mm2aX;uJI9nKEW|Y3jldolkcGmjIHPvcIkue3SrbYXsZZRm\CCLTD24JJBzd2S3Y4Tpc44hcW5iaIXtZY4hSUeVIHPlcIx{KGG2IEG1JJRwKDZyIIXtc4wwVCCjZoTldkAyOiCqcoOgZpkhTUyLU1G= NUfRW2E5OjBzNUOxPFM>
human PC3 cells MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4my[FMxOCEQvF2= NUTr[ppFPDhiaB?= MWHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZZQhOzByIIXNJIFnfGW{IES4JIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeR?= MkPuNlI1QTR4MUe=
human HCT116 cells MV;GeY5kfGmxbjDhd5NigQ>? M{O3flEhdU1? MUW2JIg> MmLrTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMTDtUUBi\nSncjC2JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> NITjbFAzOjF3NEizOC=>
human THP1 cells NYHGWmN4TnWwY4Tpc44h[XO|YYm= MXuxNFAh|ryP MmfIN|AhdWmwcx?= NHz5c5RKenKndnXyd4ljdGViaX7obYJqfGmxbjDv[kBEV1hvMTDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZZJi[2irZH;ubYMh[WOrZD3pcoR2[2WmIGTYRlIh\m:{bXH0bY9vKGG2IEGwNEB2VSCrbnP1ZoF1\WRiZn;yJFMxKG2rboOg[o9tdG:5ZXSgZpkh[2:vcH;1coQhf2G|aH;1eEBu\WG|dYLl[EA{OCCvaX7zJJBwe3RiYYLhZ4hq\G:waXOgZYNq\CClaHHscIVv\2ViYomgdoFlcW:rbX31co9ie3OjeR?= MoLnNlM3PTF|NUm=
human PANC1 cells NYfyNHVZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIj2SFg{ODBizszN MX[0PEBp NHvXNZRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSU6FMTDj[YxteyCjdDCzNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6 MViyNlQ6PDZzNx?=
human SKBR3 cells NYHwZ2xET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmS1N|AxKM7:TR?= NXzUTZFjPDhiaB?= NFmyPFRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUU0KUMzDj[YxteyCjdDCzNFAhfU1iYX\0[ZIhPDhiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6 M17hZ|IzPDl2NkG3
human MDA-MB-231 cells MXnGeY5kfGmxbjDhd5NigQ>? Mnu3NVAxKM7:TR?= MVyzNEBucW6| NFfaWXJKenKndnXyd4ljdGViaX7obYJqfGmxbjDv[kBEV1hvMTDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYYLhZ4hq\G:waXOgZYNq\C2rbnT1Z4VlKFCJRUKg[o9zdWG2aX;uJIF1KDFyMDD1UUBqdmO3YnH0[YQh\m:{IEOwJI1qdnNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDt[YF{fXKnZDCzNEBucW6|IIDvd5Qh[XKjY3jp[I9vcWNiYXPp[EBkcGGubHXu[4Uh[nlicnHkbY9qdW23bn;hd5NigQ>? MUOyN|Y2OTN3OR?=

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Protocol

Solubility (25°C)

In vitro DMSO 36 mg/mL (199.82 mM)
Ethanol 36 mg/mL (199.82 mM)
Water Insoluble
In vivo Add solvents individually and in order:
4% DMSO+PBS
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.16
Formula

C9H8O4

CAS No. 50-78-2
Storage powder
Synonyms Acetylsalicylic acid

Bio Calculators

Molarity Calculator

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02007837 Not yet recruiting Pregnancy Induced Hypertension UMC Utrecht|Ghana Health Services|University of Ghana January 2018 Phase 3
NCT02735902 Not yet recruiting Transcatheter Aortic Valve Replacement Centre Hospitalier Universitaire de Nīmes|Medtronic April 2017 Phase 4
NCT02797548 Not yet recruiting Antiplatelet Drugs Seung-Jung Park|CardioVascular Research Foundation, Korea|Asan Medical Center March 2017 Phase 4
NCT02666742 Not yet recruiting Ventricular Tachycardia Dhanunjaya Lakkireddy, MD, FACC|Bristol-Myers Squibb|University of Kansas Medical Center February 2017 Phase 4
NCT03023020 Not yet recruiting High Bleeding Risk|Coronary Artery Disease|PCI ECRI bv|Cardialysis B.V.|European Cardiovascular Research Center|University of Bern|Terumo Medical Corporation February 2017 --
NCT02984384 Not yet recruiting Blood Clot|Trauma Major Extremity Trauma Research Consortium|Patient-Centered Outcomes Research Institute February 2017 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID