Catalog No.S1645 Synonyms: RP-19583
Molecular Weight(MW): 254.28
Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
Purity & Quality Control
Choose Selective COX Inhibitors
|Description||Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.|
Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. 
|In vivo||Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey.  Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone.  Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration.  Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. |
-  Liu S, et al. Biochem Biophys Res Commun,?007, 364(3), 650-655.
-  Li KL, et al. J Periodontal Res, 1996, 31(8), 525-532.
-  Owens JG, et al. Equine Vet J,?995, 27(4), 296-300.
|In vitro||DMSO||51 mg/mL (200.56 mM)|
|Ethanol||51 mg/mL (200.56 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02905045||Not yet recruiting||Pain Relief||Assiut University||October 2016||Phase 3|
|NCT02905058||Not yet recruiting||Pain Relief||Assiut University||October 2016||Phase 3|
|NCT01685658||Not yet recruiting||Renal Colic|Acute Renal Colic||Centre Hospitalier Universitaire de Nīmes||September 2016||Phase 4|
|NCT02804126||Not yet recruiting||Cesarean Section|Pain Management|Neuropathic Pain||Michał Borys|Medical University of Lublin||June 2016||Phase 4|
|NCT02777970||Active, not recruiting||Acute Pain||Menarini Group||April 2016||Phase 4|
|NCT02730026||Active, not recruiting||Pain|Other Surgical Procedures||Luis Fernando Simoneti|Fundação de Amparo à Pesquisa do Estado de São Paulo|University of Sao Paulo||June 2015||Phase 4|
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