Ketoprofen

Catalog No.S1645 Synonyms: RP-19583

Ketoprofen  Chemical Structure

Molecular Weight(MW): 254.28

Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
Targets
COX-1 [1] COX-2 [1]
In vitro

Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]

In vivo Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 51 mg/mL (200.56 mM)
Ethanol 51 mg/mL (200.56 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 254.28
Formula

C16H14O3

CAS No. 22071-15-4
Storage powder
Synonyms RP-19583

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02905045 Not yet recruiting Pain Relief Assiut University October 2016 Phase 3
NCT02905058 Not yet recruiting Pain Relief Assiut University October 2016 Phase 3
NCT01685658 Not yet recruiting Renal Colic|Acute Renal Colic Centre Hospitalier Universitaire de Nīmes September 2016 Phase 4
NCT02804126 Not yet recruiting Cesarean Section|Pain Management|Neuropathic Pain Michał Borys|Medical University of Lublin June 2016 Phase 4
NCT02777970 Active, not recruiting Acute Pain Menarini Group April 2016 Phase 4
NCT02730026 Active, not recruiting Pain|Other Surgical Procedures Luis Fernando Simoneti|Fundação de Amparo à Pesquisa do Estado de São Paulo|University of Sao Paulo June 2015 Phase 4

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID