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Tolmetin Sodium

Name: Tolmetin Sodium
Brand: Selleck Chemicals
SKU: S4360
Rating: 5 (1 reviews)

Synonyms: MCN2559

Catalog No.S4360 Purity: 99.98%

Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

Tolmetin Sodium Chemical Structure

CAS: 64490-92-2

Purity & Quality Control

Batch: Purity: 99.98%

99.98

Tolmetin Sodium Related Products

Related Targets	COX-1 COX-2	Click to Expand
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Signaling Pathway

COX Signaling Pathway

Choose Selective COX Inhibitors

Biological Activity

Description	Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

In vitro
In vitro	Tolmetin is a nonsteroidal antiinflammatory drug (NSAID) which is useful in the treatment of rheumatoid arthritis, osteoarthritis, and gout. Tolmetin induces prostaglandin synthesis inhibition in vitro with IC50 of 3 mg/mL. ^[1]

In Vivo
In vivo	Tolmetin (100 mg/kg, po) produces a dose-dependent antinociceptive effect in rats received an intra-articular injection of uric acid in the right hindlimb, which is not directly related to blood concentration. ^[1] Tolmetin (100 mg/kg i.p.) is metabolized into tolmetin acyl-CoA (Tol-CoA), the acyl-CoA-dependent metabolites tolmetin-taurine conjugate (Tol-Tau) and tolmetin-acyl carnitine ester (Tol-Car) in liver homogenates of rats. ^[2] Tolmetin sodium (1 mg/mL in 5-15 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rabbits. Tolmetin sodium (1 mg/mL in 3 mL) is consistently efficacious in reducing postoperative adhesion formation in uterine horn and peritoneal side wall of rats. ^[3] Tolmetin (0.5-2.0 mg/mL) combined with hyaluronic acid is efficacious in reducing adhesion formation in a standardized rabbit model. ^[4] Tolmetin sodium (100 mg/kg, i.p.) transiently decreases the phagocytic capability of peritoneal leukocytes in normal rats. Tolmetin (100 mg/kg, i.p.) significantly elevates superoxide anion release at days 3 and 5, phagocytosis at days 7 and 14 and tumoricidal activity at day 3 in normal rats. ^[5]

References

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Chemical Information & Solubility

Molecular Weight	315.3	Formula	C₁₅H₁₄NO₃.Na.2H₂O
CAS No.	64490-92-2	SDF	Download Tolmetin Sodium SDF
Smiles	CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].O.O.[Na+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 63 mg/mL

Ethanol : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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