Meloxicam

Catalog No.S1734

Meloxicam Chemical Structure

Molecular Weight(MW): 351.4

Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • Meloxicam (0.25 μg/ml) decreases the migration of CF41.Mg cells. Incubation with 0.25 μg/ml meloxicam for 24 and 48 h inhibited the migration of cells compared with the DMSO‑treated control cells in a wound healing assay. A total of 6 repeats were performed and results are presented as the mean ± standard deviation. Representative images of the wound healing assay and quantification if the results are presented. Scale bar, 90 μm. *P<0.05 vs. the control group.

    Oncology letters, 2017, 2198-2206. Meloxicam purchased from Selleck.

Purity & Quality Control

Choose Selective COX Inhibitors

Biological Activity

Description Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
Targets
COX [1]
In vitro

Meloxicam significantly reduces HCA-7 and Moser-S colony size. Meloxicam significantly inhibits HCA-7 colony and tumor growth but has no effect on the growth of the COX-2 negative HCT-116 cells. [1] Meloxicam inhibits PGE(2) production, proliferation and invasiveness especially in MG-63 cells, which express relatively high levels of COX-2. Meloxicam causes apoptosis and upregulates Bax mRNA and protein in MG-63 cell culture. [2]

In vivo Meloxicam suppresses LM-8 tumor growth and lung metastasis in vivo mouse model. [2] Meloxicam causes a significant reduction in lameness at post injection hour (PIH) 8 and 24 and tends to reduce effusion in horse. Meloxicam significantly suppresses synovial fluid (SF) prostaglandin E2 and substance P release at PIH 8 and bradykinin at PIH 24 compared to placebo treatment in horse. Meloxicam reduces general MMP activity at PIH 8 and 24 in horse. [3] Meloxicam- or flunixin-treated horses has improved postoperative pain scores and clinical variables, compared with SS-treated horses. Meloxicam results in high numbers of neutrophils in ischemia-injured tissue of horse. [4] Meloxicam administration significantly suppresses PGE2 concentrations in blood and synovial fluid at days 7 and 21, but has no effect on concentrations of TXB2 in blood or PGE2 in gastric mucosa in dogs. [5]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (85.37 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 351.4
Formula

C14H13N3O4S2

CAS No. 71125-38-7
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02448199 Not yet recruiting Osteoarthritis Zodiac Produtos Farmaceuticos S.A.|Eurotrials Brasil Consultores Cientificos Ltda July 2015 Phase 3
NCT02403687 Enrolling by invitation Arthritis|Tendonitis|Gout|Radiculopathy|Muscle Spasms|Synovitis|Migraine|Headache Express Specialty Pharmacy June 2015 --
NCT02405793 Withdrawn Osteoarthritis Iroko Pharmaceuticals, LLC May 2015 Phase 2
NCT02255045 Recruiting Dysmenorrhea Laboratorios Andromaco S.A. July 2014 Phase 2|Phase 3
NCT02060006 Unknown status Tuberculosis University of Stellenbosch|University of Pittsburgh April 2014 Phase 3
NCT02078102 Recruiting Multiple Myeloma|Non-Hodgkins Lymphoma Sherif S. Farag|National Cancer Institute (NCI)|Indiana University March 2014 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID