Piroxicam

Catalog No.S1713 Synonyms: CP 16171

Piroxicam  Chemical Structure

Molecular Weight(MW): 331.35

Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
Targets
COX [1]
In vitro

Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. Piroxicam and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures. [1]

In vivo Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. [2] Piroxicam increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. Piroxicam up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. [3] Piroxicam combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. [4] Piroxicam inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and Piroxicam does not have any direct cytotoxic effects in vitro. [5] Piroxicam also binds strongly to plasma proteins and Piroxicam could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. Piroxicam prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats. [6]

Protocol

Solubility (25°C)

In vitro DMSO 66 mg/mL (199.18 mM)
Ethanol 1 mg/mL (3.01 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 331.35
Formula

C15H13N3O4S

CAS No. 36322-90-4
Storage powder
Synonyms CP 16171

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03006107 Not yet recruiting Pulpitis - Irreversible Cairo University December 2016 --
NCT02304783 Recruiting Renal Colic University of Monastir January 2014 Phase 1|Phase 2
NCT02253446 Completed Primary Dysmenorrhea Pamukkale University May 2013 Phase 4
NCT02450487 Completed Pain|Other Surgical Procedures|Impacted Third Molar Tooth|Cytochrome P450 CYP2C9 Enzyme Deficiency University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo October 2012 Phase 4
NCT01320709 Completed Contraception, Postcoital Bayer March 2011 Phase 2
NCT00670475 Completed Osteoarthritis of the Knee Ardabil University of Medical Sciences April 2008 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID