Ibuprofen Lysine  Chemical Structure

Ibuprofen Lysine Chemical Structure
Molecular Weight: 352.47

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Ibuprofen Lysine is available in the following compound libraries:

Product Information

  • Compare COX Inhibitors
    Compare COX Products
  • Research Area

Product Description

Biological Activity

Ibuprofen Lysine (NeoProfen) is a non-selective COX inhibitor with an IC50 of 0.33 mM. It is known to have an antiplatelet effect, though Ibuprofen Lysine (NeoProfen) is relatively mild and short-lived when compared with that of aspirin or other better-known antiplatelet agents. [1] Ibuprofen, indomethacin, and meclofenamate were potent inhibitors of the microsomal cyclooxygenase prepared from feline lung with IC50 of 0.33 mM, 29 μM, and 4.7 μM, respectively. [2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2015-08-29)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02452450 Completed Healthy Volunteer Study Reckitt Benckiser Healthcare (UK) Limited|Simbec Research January 2014 Phase 1

Chemical Information

Download Ibuprofen Lysine SDF
Molecular Weight (MW) 352.47
Formula

C19H32N2O4

CAS No. 57469-77-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro Water 71 mg/mL (201.43 mM)
DMSO <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Lysine 2-(p-isobutylphenyl)propionate

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related COX Products

  • Meclofenamate Sodium

    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.

  • Xanthohumol

    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

  • Metoclopramide HCl

    Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

  • Celecoxib

    Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

  • Indomethacin

    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.

  • Bufexamac

    Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

    Features:A specific inhibitor of class IIB histone deacetylases.

  • Rofecoxib

    Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.

  • Nabumetone

    Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

    Features:Greater potency than Aspirin.

  • Sulindac

    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.

  • Meloxicam

    Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

Recently Viewed Items

Tags: buy Ibuprofen Lysine | Ibuprofen Lysine ic50 | Ibuprofen Lysine price | Ibuprofen Lysine cost | Ibuprofen Lysine solubility dmso | Ibuprofen Lysine purchase | Ibuprofen Lysine manufacturer | Ibuprofen Lysine research buy | Ibuprofen Lysine order | Ibuprofen Lysine mouse | Ibuprofen Lysine chemical structure | Ibuprofen Lysine mw | Ibuprofen Lysine molecular weight | Ibuprofen Lysine datasheet | Ibuprofen Lysine supplier | Ibuprofen Lysine in vitro | Ibuprofen Lysine cell line | Ibuprofen Lysine concentration | Ibuprofen Lysine nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description
Contact Us