Bismuth Subsalicylate

Catalog No.S4032

Bismuth Subsalicylate Chemical Structure

Molecular Weight(MW): 362.09

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

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Biological Activity

Description Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
Targets
prostaglandin G/H Synthase 1/2 [1]
In vitro

Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2. [1] Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts. [2]

Protocol

Solubility (25°C)

In vitro DMSO 0.04 mg/mL (0.11 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.09
Formula

C7H5BiO4

CAS No. 14882-18-9
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02400476 Recruiting Early Stage HER2+ Breast Cancer Puma Biotechnology, Inc. February 2015 Phase 2
NCT02047162 Completed Diarrhea Centers for Disease Control and Prevention|Procter and Gamble|Health Oriented Preventive Education May 2014 --
NCT01915901 Completed Healthy Biogen August 2013 Phase 1
NCT01742429 Completed Cure Rate of Helicobacter Pylori Infection Shanghai Jiao Tong University School of Medicine November 2012 Phase 4
NCT01481844 Completed Optimization of Second Line Treatment Protocol for H Pylori Eradication Soroka University Medical Center November 2011 Phase 3
NCT00002682 Completed Lymphoma M.D. Anderson Cancer Center|National Cancer Institute (NCI) August 1995 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID