Diclofenac Diethylamine

Catalog No.S3063

Diclofenac Diethylamine Chemical Structure

Molecular Weight(MW): 369.29

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
In vitro

The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Protocol

Solubility (25°C)

In vitro DMSO 74 mg/mL (200.38 mM)
Ethanol 74 mg/mL (200.38 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.29
Formula

C14H11Cl2NO2.C4H11N

CAS No. 78213-16-8
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02985671 Not yet recruiting Postural Low Back Pain|Mechanical Low Back Pain Ache Laboratorios Farmaceuticos S.A. June 2017 Phase 3
NCT03020368 Recruiting Rhizarthrosis Charite University, Berlin, Germany January 2017 --
NCT02952898 Recruiting Actinic Keratosis Gage Development Company, LLC October 2016 Phase 3
NCT02714699 Not yet recruiting Endoscopy Assiut University September 2016 Phase 2|Phase 3
NCT02918812 Recruiting Female Infertility of Tubal Origin Bayer University Kano, Nigeria September 2016 Phase 4
NCT02837770 Completed Pain University Hospital of Patras July 2016 --

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COX Signaling Pathway Map

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