Molecular Weight(MW): 369.29
Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
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|Description||Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.|
The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
|In vitro||DMSO||74 mg/mL (200.38 mM)|
|Ethanol||74 mg/mL (200.38 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02985671||Not yet recruiting||Postural Low Back Pain|Mechanical Low Back Pain||Ache Laboratorios Farmaceuticos S.A.||June 2017||Phase 3|
|NCT03020368||Recruiting||Rhizarthrosis||Charite University, Berlin, Germany||January 2017||--|
|NCT02952898||Recruiting||Actinic Keratosis||Gage Development Company, LLC||October 2016||Phase 3|
|NCT02714699||Not yet recruiting||Endoscopy||Assiut University||September 2016||Phase 2|Phase 3|
|NCT02918812||Recruiting||Female Infertility of Tubal Origin||Bayer University Kano, Nigeria||September 2016||Phase 4|
|NCT02837770||Completed||Pain||University Hospital of Patras||July 2016||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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