Molecular Weight(MW): 314.36
Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
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Choose Selective COX Inhibitors
|Description||Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.|
|Features||Valdecoxib is more potent in inhibiting COX-2 than COX-1.|
Valdecoxib inhibits LPS-induced PGE2 production in plasma with IC50 of 0.89 μM for assessment of the extent of COX-2 inhibition. Valdecoxib inhibits TxB2 production in plasma with IC50 of 25.4 μM for assessment of the extent of COX-1 inhibition.  Valdecoxib binds to COX-2 with Ka of 1.1×105 M/s. The overall saturation binding affinity for COX-2 of Valdecoxib is 2.6 nM. Valdecoxib shows similar activity in the human whole-blood COX assay (COX-2 IC50 = 0.24 μM; COX-1 IC50 = 21.9 μM).  The affinity of [3H]Valdecoxib for COX-2 with KD of 3.2 nM. The binding of Valdecoxib to COX-2 seems to be both rapid and slowly reversible with association rates of 4.5 × 106/M/min and dissociation rates of 7.0 × 10-3/min (t1/2 of 98 min).  The percent of dissolved Valdecoxib at 15 min (DP15) is 10.5% for Valdecoxib and 50%, 91% and 93% for its hydrophilic derivatives (VALD-βCd, VALD-HPβCd and VALD-SBE7βCd complexes), respectively. 
|In vivo||Valdecoxib administrated orally inhibits rat carrageenan foot pad edema with ED50 of 10.2 mg/kg. Valdecoxib administrated orally shows chronic antiinflammatory activity with ED50 of 0.032 mg/kg/day in rat adjuvant arthritis model. Valdecoxib administrated orally shows blockade of prostaglandin production at the inflammatory site with ED50 of 0.02 mg/kg in the rat carrageenan air pouch model.  Valdecoxib demonstrates marked potency in acute and chronic models of inflammation (air pouch ED50 = 0.06 mg/kg; paw edema ED50 = 5.9 mg/kg; adjuvant arthritis ED50 = 0.03 mg/kg) in rats.  Valdecoxib alone shows slow in vivo absorption giving maximum % inhibition of edema (16%) after a period of 3 hour. In contrast, VALD-βCd and VALD-SBE7βCd complexes shows high absorption rate in vivo achieving more than 50% inhibition of edema in the 1 hour and maximum percentage of inhibition of edema (66%) after a period of 3 hours.  Valdecoxib (5 mg/kg, po) results in AUC in plasma of 3.58 μg*h/mL and 2.08 μg*h/mL in males and female mice, respectively. Valdecoxib (5 mg/kg, po) results in AUC red blood cells of 12.1 μg*h/mL and 6.42 μg*h/mL in males and female mice, respectively. |
-  Talley JJ, et al. J Med Chem, 2000, 43(5), 775-777.
-  Gierse JK, et al. J Pharmacol Exp Ther, 2005, 312(3), 1206-12012.
-  Hood WF, et al. Mol Pharmacol, 2003, 63(4), 870-877.
|In vitro||DMSO||63 mg/mL (200.4 mM)|
|Ethanol||18 mg/mL (57.25 mM)|
|In vivo||Add solvents individually and in order:
0.5% methylcellulose+0.2% Tween 80
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00260325||Completed||Pain|Hyperalgesia||Penn State University|Pfizer|National Institutes of Health (NIH)||August 2004||Phase 4|
|NCT00660855||Terminated||Pain, Post Surgical||Pfizer||June 2004||Phase 4|
|NCT00652808||Completed||Osteoarthritis|Knee||Pfizer||May 2004||Phase 3|
|NCT00650039||Completed||Pain||Pfizer||March 2004||Phase 3|
|NCT00650598||Completed||Pain, Postoperative||Pfizer||March 2004||Phase 4|
|NCT01541137||Completed||Postoperative Pain||Helsinki University Central Hospital|Academy of Finland||March 2004||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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