Catalog No.S4011 Synonyms: CP 65703
Molecular Weight(MW): 447.46
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
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|Description||Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.|
|Features||Ampiroxicam is a non-acidic ether carbonate prodrug of piroxicam.|
Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells.  Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. 
|In vivo||Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats.  Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam. |
|In vitro||DMSO||90 mg/mL (201.13 mM)|
|Water||slightly soluble or insoluble|
|Ethanol||slightly soluble or insoluble|
* 1 mg/ml means slightly soluble or insoluble.
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