Ampiroxicam

Catalog No.S4011

Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

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In DMSO USD 190 In stock
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Ampiroxicam Chemical Structure

Ampiroxicam Chemical Structure
Molecular Weight: 447.46

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Quality Control & MSDS

Product Information

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Product Description

Biological Activity

Description Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
Targets COX [1]
In vitro Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2]
In vivo Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats. [3] Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam. [4]
Features Ampiroxicam is a non-acidic ether carbonate prodrug of piroxicam.

Protocol(Only for Reference)

Cell Assay: [1]

Cell lines Panc-1 cells
Concentrations 150 μM
Incubation Time 48 hours
Method Panc-1 cells are plated in DME/F12 medium with 5% fetal bovine serum and treated on the next day with vehicle (0.1% DMSO) or various concentrations of Ampiroxicam. Cells are counted at the indicated times with a Coulter Z1 cell counter. Each experiment is done in triplicate, and results are expressed as means, with error bars representing 95% confidence intervals (CIs).

Animal Study: [3]

Animal Models Rats with adjuvant arthritis
Formulation 0.1% methylcellulose
Dosages 3.2 mg/kg
Administration Orally
1

References

[1] Abdelrahim M, et al. J Natl Cancer Inst, 2006, 98(12), 855-868.

[2] Abdelrahim M, et al. Cancer Res, 2007, 67(7), 3286-3294.

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Chemical Information

Download Ampiroxicam SDF
Molecular Weight (MW) 447.46
Formula

C20H21N3O7S

CAS No. 99464-64-9
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 90 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester

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