Trometamol

Catalog No.S4176

Trometamol Chemical Structure

Molecular Weight(MW): 121.14

Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.

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Biological Activity

Description Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.
Targets
proton acceptor [1]
In vitro

Trometamol is a proton acceptor that generates NH3 +/HCO3 - without generating CO2, and the protonated R-NH3 + is eliminated by the kidneys. Trometamol is the buffer of choice in the situation where CO2 elimination is impaired (in which case NaHCO3 cannot correct acidemia), and to avoid a Na+ load. Even during short intervals of apneic oxygenation when CO2 elimination is curtailed, trometamol, but not bicarbonate, will maintain a normal arterial pH. Trometamol also acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide and electrolytes. A significant fraction of trometamol is not ionized and therefore is capable of reaching equilibrium in total body water. This portion may penetrate cells and may neutralize acidic ions of the intracellular fluid. [1]

In vivo The drug is rapidly eliminated by the kidney; 75% or more appears in the urine after eight hours. Urinary excretion continues over a period of three days. The maximum daily dose is 15 mmol/kg for an adult. In large doses, trometamol may induce respiratory depression and hypoglycemia. [1]

Protocol

Solubility (25°C)

In vitro Water 24 mg/mL (198.11 mM)
DMSO 2 mg/mL (16.5 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 121.14
Formula

C4H11NO3

CAS No. 77-86-1
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02777970 Active, not recruiting Acute Pain Menarini Group April 2016 Phase 4
NCT02639520 Recruiting Urinary Tract Infection Bionorica SE December 2015 Phase 3
NCT02380001 Completed Postoperative Pain Daniel Chavarría Bolaños|Universidad Autonoma de San Luis Potosí January 2015 Phase 4
NCT02160236 Unknown status Postoperative Pain TC Erciyes University November 2014 Phase 4
NCT02092012 Unknown status Pain TC Erciyes University March 2014 Phase 4
NCT02086097 Completed Irreversible Pulpitis Daniel Chavarría Bolaños|Universidad Autonoma de San Luis Potosí August 2013 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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COX Signaling Pathway Map

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