Etodolac
Catalog No.S1328
Molecular Weight(MW): 287.35
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
Purity & Quality Control
Choose Selective COX Inhibitors
Biological Activity
| Description | Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain. | |
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| Targets |
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| In vitro |
Etodolac markedly inhibits ICl, vol activation by TNFα as well as subsequent apoptotic events such as apoptotic cell volume decrease (AVD) and elevation of caspase-3/7 activity in isolated rabbit articular chondrocytes. [1] |
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| In vivo | Etodolac attenuates paclitaxel-induced peripheral neuropathy by a COX-independent pathway in a mouse model of mechanical allodynia. [2] Etodolac and other NSAIDs inhibits paw swelling and causes gastric mucosal lesions in adjuvant arthritic rats in a dose-dependent manner. Etodolac shows the highest UD(50) value and safety index among these NSAIDs in arthritic rats. Etodolac also shows the highest UD(50) value and safety index, except when its effects are assessed by acetic acid-induced writhing in normal rats. [3] Etodolac dose-dependently inhibits the development of gastric cancer, and no cancer is detected at a dose of 30 mg/kg/day. Etodolac does not affect the extent of inflammatory cell infiltration or oxidative DNA damage, but it significantly inhibits mucosal cell proliferation and dose-dependently represses the development of intestinal metaplasia in the stomachs of Helicobacter pylori (Hp)-infected Mongolian gerbils (MGs). [4] Etodolac alleviates heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side is abrogated, however, it does not inhibit the decrease of bone mineral content (BMC) and bone mineral density (BMD) on the CCI-side. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 58 mg/mL (201.84 mM) |
|---|---|---|
| Ethanol | 58 mg/mL (201.84 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 287.35 |
|---|---|
| Formula | C17H21NO3 |
| CAS No. | 41340-25-4 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Dilution Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02695381 | Completed | Acute Delayed Onset Muscle Soreness (DOMS) | MEDRx USA, Inc. | March 2016 | Phase 3 |
| NCT02881619 | Completed | Medicaments Substances in Therapeutic Use | Flavia Pardo Salata Nahsan|Universidade Federal de Sergipe | November 2014 | Phase 4 |
| NCT00502684 | Unknown status | Primary Operable Breast Cancer | Kaplan Medical Center|Tel Aviv University|Tel-Aviv Sourasky Medical Center|Sheba Medical Center|Rabin Medical Center | June 2014 | -- |
| NCT01968005 | Completed | Low Back Pain | MEDRx USA, Inc. | November 2013 | Phase 3 |
| NCT01831687 | Completed | Fasting | IPCA Laboratories Ltd. | December 2012 | Phase 1 |
| NCT01827865 | Completed | Fasting | IPCA Laboratories Ltd. | November 2012 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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