Parecoxib

Catalog No.S4656 Synonyms: SC-69124, Valus-P, Vorth-P

Parecoxib Chemical Structure

Molecular Weight(MW): 370.42

Parecoxib is a selective COX2 inhibitor.

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Biological Activity

Description Parecoxib is a selective COX2 inhibitor.
Targets
COX2 [1]
In vivo Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].

Protocol

Animal Research:

[1]

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  • Animal Models: Female Sprague-Dawley rats
  • Formulation: normal saline
  • Dosages: 0.3, 1.5, 6.4 mg/kg
  • Administration: i.m.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.77 mM)
Ethanol 2 mg/mL (5.39 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 370.42
Formula

C19H18N2O4S

CAS No. 198470-84-7
Storage powder
Synonyms SC-69124, Valus-P, Vorth-P

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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