Catalog No.S1204

Melatonin Chemical Structure

Molecular Weight(MW): 232.28

Melatonin is a MT receptor agonist, used as a dietary supplement.

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In DMSO USD 90 In stock
USD 97 In stock
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2 Customer Reviews

  • C: EDU staining of adipocytes treated with MT for 24 h (n=3). D: Flow Cytometry analysis of cell cycle in adipocytes treated with MT for 24 h (n=3).

    J Pineal Res, 2016, doi: 10.1111/jpi.12383.. Melatonin purchased from Selleck.

    TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3).

    J Pineal Res, 2017. Melatonin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Melatonin is a MT receptor agonist, used as a dietary supplement.
melatonin receptor [1]
In vitro

Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. [1] Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Melatonin reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. Melatonin stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. [2] Melatonin in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO*), with little or no ability to scavenge the superoxide anion radical (O2*-) in vitro. Melatonin also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. [3] Melatonin inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. Melatonin also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells Mn:wSpVv[3Srb36gZZN{[Xl? Ml\QRolv\GmwZzDh[oZqdmm2eTDmc5IhcHWvYX6gcYVt[XSxbnnuJJJm[2WydH;yJJR6eGViMVGsJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgLFIuYzF{NVndbY9ld22nbHH0c45qdiCrczD1d4VlKGG|IILh[IlwdGmpYX7kLUwhU2l;MD6yJI5O MXOxNVA3OzZyMh?=
NIH 3T3 cells M2D1dmZ2dmO2aX;uJIF{e2G7 MmnpRolv\GmwZzDh[oZqdmm2eTD0c5diemS|IILlZ49u[mmwYX70JIh2dWGwIH3lcIF1d26rbjDy[YNmeHSxcjD0fZBmKDGDIHX4dJJme3OnZDDpckBPUUhiM2SzJINmdGy|IIXzbY5oKDJvW{GyNWlecW:mb33lcIF1d26rbjDyZYRqd2yrZ3Hu[EBjcW6maX7nJIF{e2G7LDDLbV0xNjZ4IH7N NXzld4VTOTB5M{e3N|g>
NIH3T3 cells NIP0XotHfW6ldHnvckBie3OjeR?= NHPjT3hDcW6maX7nJIFn\mmwaYT5JIFo[Wmwc4SgbJVu[W5iTWSxJI1mdGG2b37pckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iTlnIN3Q{KGOnbHzzMEBMcT1yLkSgcm0> M2XrTlE1PjR|M{Ow
CHO cells M4\VUGZ2dmO2aX;uJIF{e2G7 NHPMO3VKdmirYnn0bY9vKG:oIITo[UAzNVtzMkXJYU0hcW:mb33lcIF1d26rbjDibY5lcW6pIITvJG1mdGG2b37pckBz\WOncITvdkB1gXCnIEHBJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNuIFvpQVgvODCHLUC1JO69VQ>? MkWyPVQ{PTh7MB?=
NIH3T3 cells MXjGeY5kfGmxbjDhd5NigQ>? NULsfnYySmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JIh2dWGwIF3UNkBu\WyjdH;ubY4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIF7JTFNVOyClZXzsd{whU2l;MD6zJI5O Ml3JNVQ3PDN|M{C=
CHO-Galpha16 cells MXPGeY5kfGmxbjDhd5NigQ>? Mlm2NlAhdWmwcx?= NFjz[GdDcW6maX7nJIFn\mmwaYT5JJRwKHKjdDDNWFEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPIU{1I[WyyaHGxOkBk\WyuczDhd5Nme3OnZDDhd{BE[TJtIH3vZoltcXqjdHnvckBi\nSncjCyNEBucW6|IHL5JGZNUVCUIHHzd4F6NCCHQ{WwQVAvPTZibl2= M{\q[FIyOjN5NkS0
NIH3T3 cells MUTGeY5kfGmxbjDhd5NigQ>? NY\wXnNFQTBibXnudy=> MoHFSIl{eGyjY3Xt[Y51KG:oIEKtX|EzPUmfaX;kc41mdGG2b37pckBnem:vIHj1cYFvKE2WMTDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hemG2IF7JTFNVOyClZXzsd{Bi\nSncjC5NEBucW6|LDDLbV0xNjJ4MzDuUS=> MkTlNlIxPDd3NU[=
NIH3T3 cells NYPPZZBuTnWwY4Tpc44h[XO|YYm= NF;SRoQ6OCCvaX7z NF2zVldFcXOybHHj[Y1mdnRib3[gNk1cOTJ3SW3pc4RwdWWuYYTvcolvKG[{b32gbJVu[W5iTWSyJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiC{YYSgUmlJO1R|IHPlcIx{KGGodHXyJFkxKG2rboOsJGtqRTBwM{O5JI5O NFjmfHIzOjB2N{W1Oi=>
CHOK1 MknDSpVv[3Srb36gZZN{[Xl? NIDPdY8{KGh? NXXjXI5{TGm|cHzhZ4Vu\W62IH;mJHsyOjWLXUKtbY9ld22nbHH0c45qdiCocn;tJIh2dWGwIILlZ49u[mmwYX70JI1mdGG2b37pckBz\WOncITvdkAyKGW6cILld5Nm\CCrbjDDTG9MOSClZXzsd{Bi\nSncjCzJIhzeyxiSVO1NF0xNjJzIH7N NFnsR3kzOzRyM{C4Ni=>
SH-SY5Y cells MUnGeY5kfGmxbjDhd5NigQ>? M{izb|ExKM7:TR?= NYSxNZFlOjRiaB?= NFvyOm5P\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDINm8zNWmwZIXj[YQhd3irZHH0bZZmKHO2cnXzd{1ie3OxY3nheIVlKGSnYYToJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZZQhOTBidV2gbY5kfWKjdHXkJIZweiB{NDDodpMheHKrb4KgeI8hUDKRMjDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeR?= MWOyOlM3Ozh4Nh?=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 47 mg/mL (202.34 mM)
Ethanol 47 mg/mL (202.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 232.28


CAS No. 73-31-4
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03043443 Recruiting Alcohol-Related Disorders Centre for Addiction and Mental Health January 25, 2017 --
NCT00097474 Completed Jet Lag Syndrome Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) November 22, 2004 Phase 2
NCT02798367 Not yet recruiting Insomnia Disorder Ache Laboratorios Farmaceuticos S.A. August 2017 Phase 2|Phase 3
NCT02963181 Not yet recruiting Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases Lawson Health Research Institute January 2017 Early Phase 1
NCT03013790 Recruiting Delirium|Melatonin MICE Trial Group December 2016 Phase 4
NCT02993588 Recruiting In Vitro Fertilization|Poor Ovarian Response Assiut University December 2016 Phase 2|Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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MT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID