Catalog No.S1204

Melatonin Chemical Structure

Molecular Weight(MW): 232.28

Melatonin is a MT receptor agonist, used as a dietary supplement.

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In DMSO USD 90 In stock
USD 97 In stock
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2 Customer Reviews

  • C: EDU staining of adipocytes treated with MT for 24 h (n=3). D: Flow Cytometry analysis of cell cycle in adipocytes treated with MT for 24 h (n=3).

    J Pineal Res, 2016, doi: 10.1111/jpi.12383.. Melatonin purchased from Selleck.

    TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3).

    J Pineal Res, 2017. Melatonin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Melatonin is a MT receptor agonist, used as a dietary supplement.
melatonin receptor [1]
In vitro

Melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. [1] Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Melatonin reportedly scavenges the superoxide anion radical and it quenches singlet oxygen. Melatonin stimulates mRNA levels for superoxide dismutase and the activities of glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase (all of which are antioxidative enzymes), thereby increasing its antioxidative capacity. [2] Melatonin in cell-free systems has been shown to directly scavenge H2O2, singlet oxygen (1O2) and nitric oxide (NO*), with little or no ability to scavenge the superoxide anion radical (O2*-) in vitro. Melatonin also directly detoxifies the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH), or the activated form of this molecule, ONOOH*. Melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species. [3] Melatonin inhibits cAMP accumulation in most of the cells examined, but the indole effects on other messengers have been often observed only in one type of the cells or tissue, until now. Melatonin also regulates the transcription factors, namely, phosphorylation of cAMP-responsive element binding protein and expression of c-Fos. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells NGrqcHBHfW6ldHnvckBie3OjeR?= M{L5Z2JqdmSrbnegZYZncW6rdImg[o9zKGi3bXHuJI1mdGG2b37pckBz\WOncITvdkB1gXCnIEHBMEBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJEgzNVtzMkXJYYlw\G:vZXzheI9vcW5iaYOgeZNm\CCjczDyZYRqd2yrZ3Hu[EktKEurPUCuNkBvVQ>? MYexNVA3OzZyMh?=
NIH 3T3 cells NED2dWJHfW6ldHnvckBie3OjeR?= NEPubYRDcW6maX7nJIFn\mmwaYT5JJRwf2G{ZIOgdoVkd22kaX7hcpQhcHWvYX6gcYVt[XSxbnnuJJJm[2WydH;yJJR6eGViMVGg[ZhxemW|c3XkJIlvKE6LSDCzWFMh[2WubIOgeZNqdmdiMj3bNVIyUV2rb3TvcYVt[XSxbnnuJJJi\GmxbHnnZY5lKGKrbnTpcoch[XO|YYmsJGtqRTBwNk[gcm0> NYKybXo{OTB5M{e3N|g>
NIH3T3 cells NUnHS25uTnWwY4Tpc44h[XO|YYm= M3PjbWJqdmSrbnegZYZncW6rdImgZYdicW6|dDDoeY1idiCPVEGgcYVt[XSxbnnuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCQSVizWFMh[2WubIOsJGtqRTBwNDDuUS=> NH7RN5kyPDZ2M{OzNC=>
CHO cells NXPDd5BoTnWwY4Tpc44h[XO|YYm= M4e0b2lvcGmkaYTpc44hd2ZidHjlJFIuYzF{NVndMUBqd2SxbXXsZZRwdmmwIHLpcoRqdmdidH:gUYVt[XSxbnnuJJJm[2WydH;yJJR6eGViMVGg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyxiS3m9PE4xOEVvMEWg{txO NXn6S4xEQTR|NUi5NC=>
NIH3T3 cells MYTGeY5kfGmxbjDhd5NigQ>? M4\GbGJqdmSrbnegZYZncW6rdImgZYdicW6|dDDoeY1idiCPVEKgcYVt[XSxbnnuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCQSVizWFMh[2WubIOsJGtqRTBwMzDuUS=> NGTTWJAyPDZ2M{OzNC=>
CHO-Galpha16 cells NYS0O2xzTnWwY4Tpc44h[XO|YYm= M4raOFIxKG2rboO= MYHCbY5lcW6pIHHm[olvcXS7IITvJJJifCCPVEGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTz3HZYxxcGFzNjDj[YxteyCjc4Pld5Nm\CCjczDDZVIsKG2xYnnsbZpifGmxbjDh[pRmeiB{MDDtbY5{KGK7IF\MTXBTKGG|c3H5MEBGSzVyPUCuOVYhdk1? NYr5V|BrOjF{M{e2OFQ>
NIH3T3 cells NUXQc3dDTnWwY4Tpc44h[XO|YYm= NEDQW|E6OCCvaX7z NIS0c|lFcXOybHHj[Y1mdnRib3[gNk1cOTJ3SW3pc4RwdWWuYYTvcolvKG[{b32gbJVu[W5iTWSxJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiC{YYSgUmlJO1R|IHPlcIx{KGGodHXyJFkxKG2rboOsJGtqRTBwMk[zJI5O MWCyNlA1PzV3Nh?=
NIH3T3 cells NGe4PFNHfW6ldHnvckBie3OjeR?= NIPyeJg6OCCvaX7z MkXISIl{eGyjY3Xt[Y51KG:oIEKtX|EzPUmfaX;kc41mdGG2b37pckBnem:vIHj1cYFvKE2WMjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hemG2IF7JTFNVOyClZXzsd{Bi\nSncjC5NEBucW6|LDDLbV0xNjN|OTDuUS=> MmPwNlIxPDd3NU[=
CHOK1 NG\6To9HfW6ldHnvckBie3OjeR?= NYnpeFBwOyCq NVvEZ2lNTGm|cHzhZ4Vu\W62IH;mJHsyOjWLXUKtbY9ld22nbHH0c45qdiCocn;tJIh2dWGwIILlZ49u[mmwYX70JI1mdGG2b37pckBz\WOncITvdkAyKGW6cILld5Nm\CCrbjDDTG9MOSClZXzsd{Bi\nSncjCzJIhzeyxiSVO1NF0xNjJzIH7N NV;F[ZJIOjN2MEOwPFI>
SH-SY5Y cells NH32ZpFHfW6ldHnvckBie3OjeR?= MkPFNVAh|ryP MViyOEBp NV[wW3FuVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTFJQOi2rbnT1Z4VlKG:6aXTheIl3\SC|dILld5Mu[XO|b3PpZZRm\CCmZXH0bEBqdiCqdX3hckBUUC2VWUXZJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIF1KDFyIIXNJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KHC{aX;yJJRwKEh{T{KgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYm= NELGUpIzPjN4M{i2Oi=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 47 mg/mL (202.34 mM)
Ethanol 47 mg/mL (202.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 232.28


CAS No. 73-31-4
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03043443 Recruiting Alcohol-Related Disorders Centre for Addiction and Mental Health January 25, 2017 --
NCT00097474 Completed Jet Lag Syndrome Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) November 22, 2004 Phase 2
NCT02798367 Not yet recruiting Insomnia Disorder Ache Laboratorios Farmaceuticos S.A. August 2017 Phase 2|Phase 3
NCT02963181 Not yet recruiting Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases Lawson Health Research Institute January 2017 Early Phase 1
NCT03013790 Recruiting Delirium|Melatonin MICE Trial Group December 2016 Phase 4
NCT02993588 Recruiting In Vitro Fertilization|Poor Ovarian Response Assiut University December 2016 Phase 2|Phase 3

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MT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID