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S1261

Celecoxib

 (Synonyms

Celebrex, Celebra

)
Technical Data:
Celecoxib
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M.Wt: 381.37
Formula: C17H14F3N3O2S
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 169590-42-5
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Batch S126101:H-NMR  COA
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    • Biological Activity of Celecoxib:

    Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production). [1]
    Celecoxib is more selective for COX-2 (IC50=0.04μM)inhibition over COX-1(IC50=15μM). [2]It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. [1]
    Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. [1]
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