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Celecoxib
(SynonymsCelebrex, Celebra
)Add to Favor
M.Wt: 381.37
Formula: C17H14F3N3O2S
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 169590-42-5
Price and Availability of Celecoxib:
Applications & Customer's Feedback of Celecoxib:
Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL). ------ Ralfkiaer U,Hagedorn PH,et al. Blood. 2011 Nov;118:5891-900
Biological Activity of Celecoxib:
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production). [1]
Celecoxib is more selective for COX-2 (IC50=0.04μM)inhibition over COX-1(IC50=15μM). [2]It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. [1]
Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. [1]
References on Celecoxib:
[1] http://en.wikipedia.org/wiki/Celecoxib
[2] Neelam Seedher and Sonu Bhatia. AAPS PharmSciTech. 2003,4(3):33
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