Home Immunology & Inflammation COX inhibitor 4-Aminoantipyrine For research use only.

4-Aminoantipyrine

Synonyms: Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene, Aminoantipyrin

4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

4-Aminoantipyrine Chemical Structure

4-Aminoantipyrine Chemical Structure

CAS: 83-07-8

Purity & Quality Control

Batch: S450901 DMSO] 40 mg/mL] false] Water] 40 mg/mL] false] Ethanol] 40 mg/mL] false Purity: 99.23%
99.23

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Signaling Pathway

COX Signaling Pathways

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Biological Activity

Description 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
In vitro
In vitro The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].
Cell Research Cell lines Human erythrocytes
Concentrations 1 × 10−6 mol/L to 1 × 10−3 mol/L
Incubation Time 2 h
Method

Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH.
In Vivo
In vivo 4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].
Animal Research Animal Models Male Wistar rats
Dosages 240 µmol/kg
Administration iv(caudal vein)

Chemical Information & Solubility

Molecular Weight 203.24 Formula

C11H13N3O
CAS No. 83-07-8 SDF Download 4-Aminoantipyrine SDF
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (196.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 40 mg/mL

Ethanol : 40 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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