Nabumetone

Catalog No.S4051 Synonyms: BRL-14777

Nabumetone Chemical Structure

Molecular Weight(MW): 228.29

Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

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Biological Activity

Description Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
Features Greater potency than Aspirin.
Targets
COX [1]
In vitro

Nabumetone is a nonsteroidal anti-inflammatory prodrug. Nabumetone itself is non-acidic and, following absorption, it undergoes extensive first-pass metabolism to form the main circulating active metabolite (6-MNA) which is a much more potent inhibitor of preferentially COX-2. [1]

In vivo Nabumetone displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs. Its activity in these tests is greater than that of aspirin but less than that of naproxen and indomethacin. In the cotton pellet-induced granuloma model in the rat, Nabumetone is active and produces no signs of toxicity at doses much greater than the lowest effective dose, unlike aspirin, naproxen or indomethacin. Nabumetone is also active in the adjuvant-induced arthritis test in rats. In contrast to aspirin, indomethacin and naproxen, Nabumetone is well tolerated by the stomach of fasted rats at doses in excess of those with anti-inflammatory activity. [2]

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (201.49 mM)
Ethanol 25 mg/mL (109.5 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 228.29
Formula

C15H16O2

CAS No. 42924-53-8
Storage powder
Synonyms BRL-14777

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00864604 Completed Healthy Actavis Inc. April 2007 Phase 1
NCT00864968 Completed Healthy Actavis Inc. February 2007 Phase 1
NCT01164826 Completed Healthy Dr. Reddys Laboratories Limited March 2006 Phase 1
NCT01164813 Completed Healthy Dr. Reddys Laboratories Limited March 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID