Asaraldehyde

Catalog No.S2531 Synonyms: Asaronaldehyde

Asaraldehyde Chemical Structure

Molecular Weight(MW): 196.2

Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 228 In stock
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Biological Activity

Description Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
Targets
COX-2 [2]
In vitro

Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, Asaraldehyde is produced in both cultured broths. [1] Asaraldehyde shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. Asaraldehyde shows selectivity towards COX-2 enzyme inhibition at 100 µg/mL. The COX-2/COX-1 ratio for Asaraldehyde is 17.68 at 100 µg/mL compared to solvent control. [2] Asaraldehyde down-regulates C/EBPβ, C/EBPδ, and C/EBPα. Asaraldehyde suppresses expression of PPARγ1 and PPARγ2. Asaraldehyde also significantly suppresses the expression of acetyl-CoA carboxylase (ACC). [2]

Protocol

Cell Research:[3]
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  • Cell lines: 3T3-L1 cells
  • Concentrations: 100 μg/mL
  • Incubation Time: 24 hours
  • Method: 3T3-L1 cells are seeded in 96-well plates at a concentration of 104 /well. Twenty-four hours after seeding, the cells are treated with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Fully differentiated adipocytes are also treated with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. At the end of treatment, cells are cultured with MTT at a final concentration of 0.5 mg/mL for another 4 hours. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 39 mg/mL (198.77 mM)
Ethanol 16 mg/mL (81.54 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 196.2
Formula

C10H12O4

CAS No. 4460-86-0
Storage powder
Synonyms Asaronaldehyde

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID