Home Neuronal Signaling COX inhibitor - IFN inhibitor Bufexamac For research use only.

Bufexamac

Synonyms: Bufexamic acid

Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

Bufexamac Chemical Structure

Bufexamac Chemical Structure

CAS: 2438-72-4

Selleck's Bufexamac has been cited by 5 Publications

2 Customer Reviews

Purity & Quality Control

Batch: S302301 DMSO] 45 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.48%
99.48

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Biological Activity

Description Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
Features A specific inhibitor of class IIB histone deacetylases.
Targets
IFN-α [1]
8.9 μM
In vitro
In vitro

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. [1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. [2]

Chemical Information & Solubility

Molecular Weight 223.27 Formula

C12H17NO3
CAS No. 2438-72-4 SDF Download Bufexamac SDF
Smiles CCCCOC1=CC=C(C=C1)CC(=O)NO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (201.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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