Diflunisal

Catalog No.S4609 Synonyms: Dolobid, Dolobis, Flovacil, Fluniget

Diflunisal Chemical Structure

Molecular Weight(MW): 250.20

Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.

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Description Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.
Targets
COX [1]
()
p300 [2]
996 μM
In vitro

Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2].

In vivo Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: HEK293T cells
  • Concentrations: 0, 100, 200, 400 μM
  • Incubation Time: 24 h
  • Method:

    HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Sprague-Dawley rats, Female New Zealand White Rabbits
  • Formulation: 0.5% methylcellulose
  • Dosages: 250 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (199.84 mM)
Ethanol 20 mg/mL (79.93 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 250.20
Formula

C13H8F2O3

CAS No. 22494-42-4
Storage powder
Synonyms Dolobid, Dolobis, Flovacil, Fluniget

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID