Dabigatran etexilate mesylate

For research use only.

Catalog No.S5960 Synonyms: Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate

1 publication

Dabigatran etexilate mesylate Chemical Structure

CAS No. 872728-81-9

Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.

Selleck's Dabigatran etexilate mesylate has been cited by 1 publication

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Biological Activity

Description Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.
Targets
human thrombin [1]
(Cell-free assay)
4.5 nM(Ki)

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (138.15 mM)
Water Insoluble
Ethanol '''20 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 723.84
Formula

C35H45N7O8S

CAS No. 872728-81-9
Storage powder
in solvent
Synonyms Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02839746 Completed -- Atrial Fibrillation Boehringer Ingelheim June 13 2016 --
NCT02684981 Completed -- Atrial Fibrillation|Stroke Boehringer Ingelheim November 11 2015 --
NCT02433366 Completed -- Atrial Fibrillation Boehringer Ingelheim January 2015 --
NCT01139658 Completed -- Venous Thromboembolism Boehringer Ingelheim August 2010 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID