Dabigatran etexilate mesylate
For research use only.
Catalog No.S5960 Synonyms: Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate
CAS No. 872728-81-9
Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.
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|Description||Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.|
|In vitro||DMSO||100 mg/mL (138.15 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02839746||Completed||--||Atrial Fibrillation||Boehringer Ingelheim||June 13 2016||--|
|NCT02684981||Completed||--||Atrial Fibrillation|Stroke||Boehringer Ingelheim||November 11 2015||--|
|NCT02433366||Completed||--||Atrial Fibrillation||Boehringer Ingelheim||January 2015||--|
|NCT01139658||Completed||--||Venous Thromboembolism||Boehringer Ingelheim||August 2010||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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