H2 receptor Selective Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1890 Nizatidine

Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.

Selective Histamine H2 receptor, IC50: 0.9 nM
S1880 Roxatidine Acetate HCl

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Selective Histamine H2 receptor, IC50: 3.2 μM
S1801 Ranitidine Hydrochloride

Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Selective
S1845 Cimetidine

Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Selective
S2078 Famotidine

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Selective
S2065 Lafutidine

Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

Selective
S4625 Alcaftadine

Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.

Pan H2 receptor, pKi: 7.2
S4117 Histamine Phosphate

Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.

Pan
S4118 Histamine 2HCl

Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

Pan