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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C29H43BrN2O4 |
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| Molecular Weight | 563.57 | CAS No. | 26095-59-0 | ||||
| Solubility (25°C)* | In vitro | DMSO | 113 mg/mL (200.5 mM) | ||||
| Water | 113 mg/mL (200.5 mM) | ||||||
| Ethanol | 113 mg/mL (200.5 mM) | ||||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Otilonium bromide is an antimuscarinic. | |
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| In vitro | Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. |
Protocol (from reference)
References
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Selleck's Otilonium Bromide Has Been Cited by 5 Publications
| Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines [ Biochem Pharmacol, 2023, 215:115746] | PubMed: 37579857 |
| Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines [ Biochemical Pharmacology, 2023, 115746] | PubMed: 37579857 |
| Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses [ Bioorganic Chemistry, 2022 Nov 09, 106264] | PubMed: 36395603 |
| Therapeutic potential of otilonium bromide against Vibrio vulnificus [ Res Microbiol, 2022, S0923-2508(22)00073-0] | PubMed: 36122890 |
| Spore Germination as a Target for Antifungal Therapeutics [ Antimicrobial Agents and Chemotherapy, 2019 Nov 21, e00994-19] | PubMed: 31570398 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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