IDO-IN-2

For research use only.

Catalog No.S7111 Synonyms: RG 6078, NLG-919 analogue, GDC-0919 analogue

10 publications

IDO-IN-2 Chemical Structure

CAS No. 1402836-58-1

IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.

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USD 570 In stock
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Selleck's IDO-IN-2 has been cited by 10 publications

2 Customer Reviews

  • Inhibitor sensitivity of tryptophan 2,3-dioxygenase (TDO) in N-formylkynurenine (NFK) Green assay. Dose-response curves of INCB024360, S7111, and NTRC 0820-0 with IC50 values 67 nM and 75 nM, respectively.

    J Biomol Screen 2014 10.1177/1087057114536616. IDO-IN-2 purchased from Selleck.

    B) Cellular IC50 value (μM) of VIS351 (14, filled circle) and NLG919 (as reference inhibitor, open circle) obtained from a dose–response curve. P1.IDO1 cells were exposed to six times 3-fold serial dilutions of NLG919 (concentrations ranging from 0.0003 to 0.1 μM) and eight times 3-fold serial dilutions of VIS351 (concentrations ranging from 0.03 to 90 μM). Results are the mean ± SD of the Kyn fold change (Kyn FC) of three independent experiments, each performed in triplicate. D) Enzymatic IC50 of VIS351 (14, filled circle) and NLG919 (open circle) are determined on recombinant human IDO1, using seven times 10-fold dilutions of the molecules, starting from 2 mM. Kyn FC values are represented as the mean ± SD of three independent experiments, each performed in triplicate.

    Biochem Pharmacol, 2018, 158:286-297. IDO-IN-2 purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
Targets
IDO1 [2]
(Cell-free assay)
38 nM
In vitro

IDO-IN-2 (NLG-919 analogue, Compound 24) contains an imidazoleisoindole core and exhibits potent inhibitory activity to IDO1 with the IC50 value of 38 nM. IDO-IN-2 inhibits IDO activity with EC50 of 61 nM in HeLa cellular assay. The binding mode of IDO-IN-2 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme.[2] IDO-IN-2 (Compound 7) has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NVLocJk3TnWwY4Tpc44h[XO|YYm= M{\aUWlvcGmkaYTpc44hd2ZiSVTPNUBqdiCLRl7nZY1u[S2|dHnteYxifGWmIHj1cYFvKEinTHGgZ4VtdHNiaX7jeYJifGWmIH\vdkAzPCCqcoOsJGVEPTB;MD6wOlEh|ryP NGe1V3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[0NlM4Pyd-Mk[2OFI{Pzd:L3G+
HeLa NXixUGVLTnWwY4Tpc44h[XO|YYm= MmrDTY5pcWKrdHnvckBw\iCLRF:xJIlvKEmITj3nZY1u[SC|dHnteYxifGWmIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCteX71doVvcW6nIIDyc4R2[3Srb36gdJJmNWmwY4XiZZRm\CCob4KgNUBpeiCob3zsc5dm\CCkeTDJSm4u\2GvbXGgZYRlcXSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE5KGi{czygTWM2OD1yLkCwOO69VS5? M{i2WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{m4OVQ{Lz5{OUO5PFU1OzxxYU6=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 30 mg/mL (106.23 mM)
DMSO 15 mg/mL warmed (53.11 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 282.38
Formula

C18H22N2O

CAS No. 1402836-58-1
Storage powder
in solvent
Synonyms RG 6078, NLG-919 analogue, GDC-0919 analogue
Smiles C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O

In vivo Formulation Calculator (Clear solution)

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Dilution Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    NLG919 has two chiral centers in compound, so which isoform (RR, RS,SR,SS) of NLG919 that you sale ? or it

  • Answer:

    NLG919 is synthesized as a racemate, a mixture of four isoform (RR, RS,SR,SS).

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID