Catalog No.S7111 Synonyms: Navoximod

NLG919 Chemical Structure

Molecular Weight(MW): 282.38

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.

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Cited by 2 Publications

1 Customer Review

  • Inhibitor sensitivity of tryptophan 2,3-dioxygenase (TDO) in N-formylkynurenine (NFK) Green assay. Dose-response curves of INCB024360, S7111, and NTRC 0820-0 with IC50 values 67 nM and 75 nM, respectively.

    J Biomol Screen 2014 10.1177/1087057114536616. NLG919 purchased from Selleck.

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Biological Activity

Description NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.
IDO [1]
(Cell-free assay)
75 nM(EC50)
In vitro

NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM. [1]

In vivo In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.[1]


Solubility (25°C)

In vitro Ethanol 30 mg/mL (106.23 mM)
DMSO 15 mg/mL warmed (53.11 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 282.38


CAS No. 1402836-58-1
Storage powder
in solvent
Synonyms Navoximod

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    NLG919 has two chiral centers in compound, so which isoform (RR, RS,SR,SS) of NLG919 that you sale ? or it

  • Answer:

    NLG919 is synthesized as a racemate, a mixture of four isoform (RR, RS,SR,SS).

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID