IDO-IN-2

Catalog No.S7111 Synonyms: RG 6078, NLG-919 analogue, GDC-0919 analogue

For research use only.

IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.

IDO-IN-2 Chemical Structure

CAS No. 1402836-58-1

Selleck's IDO-IN-2 has been cited by 11 Publications

2 Customer Reviews

Purity & Quality Control

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Biological Activity

Description IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
Targets
IDO1 [2]
(Cell-free assay)
38 nM
In vitro

IDO-IN-2 (NLG-919 analogue, Compound 24) contains an imidazoleisoindole core and exhibits potent inhibitory activity to IDO1 with the IC50 value of 38 nM. IDO-IN-2 inhibits IDO activity with EC50 of 61 nM in HeLa cellular assay. The binding mode of IDO-IN-2 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme.[2] IDO-IN-2 (Compound 7) has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa MYHGeY5kfGmxbjDhd5NigQ>? NWnyT2drUW6qaXLpeIlwdiCxZjDJSG8yKGmwIFnGUodidW2jLYP0bY12dGG2ZXSgbJVu[W5iSHXMZUBk\WyuczDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{whTUN3ME2wMlA3OSEQvF2= NF;xXnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[0NlM4Pyd-Mk[2OFI{Pzd:L3G+
HeLa MVLGeY5kfGmxbjDhd5NigQ>? MknPTY5pcWKrdHnvckBw\iCLRF:xJIlvKEmITj3nZY1u[SC|dHnteYxifGWmIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCteX71doVvcW6nIIDyc4R2[3Srb36gdJJmNWmwY4XiZZRm\CCob4KgNUBpeiCob3zsc5dm\CCkeTDJSm4u\2GvbXGgZYRlcXSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE5KGi{czygTWM2OD1yLkCwOO69VS5? M4\HblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{m4OVQ{Lz5{OUO5PFU1OzxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

Ethanol 30 mg/mL
(106.23 mM)
DMSO 15 mg/mL warmed
(53.11 mM)
Water Insoluble

Chemical Information

Molecular Weight 282.38
Formula

C18H22N2O

CAS No. 1402836-58-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02471846 Completed Drug: Atezolizumab|Drug: GDC-0919 Solid Tumor Genentech Inc. July 28 2015 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
NLG919 has two chiral centers in compound, so which isoform (RR, RS,SR,SS) of NLG919 that you sale ? or it

Answer:
NLG919 is synthesized as a racemate, a mixture of four isoform (RR, RS,SR,SS).

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