For research use only.
Catalog No.S7111 Synonyms: RG 6078, NLG-919 analogue, GDC-0919 analogue
CAS No. 1402836-58-1
IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
Selleck's IDO-IN-2 has been cited by 10 publications
2 Customer Reviews
Inhibitor sensitivity of tryptophan 2,3-dioxygenase (TDO) in N-formylkynurenine (NFK) Green assay. Dose-response curves of INCB024360, S7111, and NTRC 0820-0 with IC50 values 67 nM and 75 nM, respectively.
J Biomol Screen 2014 10.1177/1087057114536616. IDO-IN-2 purchased from Selleck.
B) Cellular IC50 value (μM) of VIS351 (14, filled circle) and NLG919 (as reference inhibitor, open circle) obtained from a dose–response curve. P1.IDO1 cells were exposed to six times 3-fold serial dilutions of NLG919 (concentrations ranging from 0.0003 to 0.1 μM) and eight times 3-fold serial dilutions of VIS351 (concentrations ranging from 0.03 to 90 μM). Results are the mean ± SD of the Kyn fold change (Kyn FC) of three independent experiments, each performed in triplicate. D) Enzymatic IC50 of VIS351 (14, filled circle) and NLG919 (open circle) are determined on recombinant human IDO1, using seven times 10-fold dilutions of the molecules, starting from 2 mM. Kyn FC values are represented as the mean ± SD of three independent experiments, each performed in triplicate.
Biochem Pharmacol, 2018, 158:286-297. IDO-IN-2 purchased from Selleck.
Purity & Quality Control
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|Description||IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.|
IDO-IN-2 (NLG-919 analogue, Compound 24) contains an imidazoleisoindole core and exhibits potent inhibitory activity to IDO1 with the IC50 value of 38 nM. IDO-IN-2 inhibits IDO activity with EC50 of 61 nM in HeLa cellular assay. The binding mode of IDO-IN-2 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-2 (Compound 7) has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.
|In vitro||Ethanol||30 mg/mL (106.23 mM)|
|DMSO||15 mg/mL warmed (53.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||RG 6078, NLG-919 analogue, GDC-0919 analogue|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02471846||Completed||Drug: Atezolizumab|Drug: GDC-0919||Solid Tumor||Genentech Inc.||July 28 2015||Phase 1|
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Frequently Asked Questions
NLG919 has two chiral centers in compound, so which isoform (RR, RS,SR,SS) of NLG919 that you sale ? or it
NLG919 is synthesized as a racemate, a mixture of four isoform (RR, RS,SR,SS).