Catalog No.S7111 Synonyms: Navoximod
Molecular Weight(MW): 282.38
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.
2 Customer Reviews
Inhibitor sensitivity of tryptophan 2,3-dioxygenase (TDO) in N-formylkynurenine (NFK) Green assay. Dose-response curves of INCB024360, S7111, and NTRC 0820-0 with IC50 values 67 nM and 75 nM, respectively.
J Biomol Screen 2014 10.1177/1087057114536616. NLG919 purchased from Selleck.
B) Cellular IC50 value (μM) of VIS351 (14, filled circle) and NLG919 (as reference inhibitor, open circle) obtained from a dose–response curve. P1.IDO1 cells were exposed to six times 3-fold serial dilutions of NLG919 (concentrations ranging from 0.0003 to 0.1 μM) and eight times 3-fold serial dilutions of VIS351 (concentrations ranging from 0.03 to 90 μM). Results are the mean ± SD of the Kyn fold change (Kyn FC) of three independent experiments, each performed in triplicate. D) Enzymatic IC50 of VIS351 (14, filled circle) and NLG919 (open circle) are determined on recombinant human IDO1, using seven times 10-fold dilutions of the molecules, starting from 2 mM. Kyn FC values are represented as the mean ± SD of three independent experiments, each performed in triplicate.
Biochem Pharmacol, 2018, 158:286-297. NLG919 purchased from Selleck.
Purity & Quality Control
Choose Selective IDO/TDO Inhibitors
|Description||NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1.|
NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM. 
|In vivo||In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.|
|In vitro||Ethanol||30 mg/mL (106.23 mM)|
|DMSO||15 mg/mL warmed (53.11 mM)|
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Frequently Asked Questions
NLG919 has two chiral centers in compound, so which isoform (RR, RS,SR,SS) of NLG919 that you sale ? or it
NLG919 is synthesized as a racemate, a mixture of four isoform (RR, RS,SR,SS).