INCB024360 analogue

Catalog No.S7587 Synonyms: INCB14943

INCB024360 analogue Chemical Structure

Molecular Weight(MW): 271.64

INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.

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Biological Activity

Description INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.
IDO1 [1]
(Cell-free assay)
67 nM
In vitro

In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM. [1] In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HeLa cells MUXGeY5kfGmxbjDhd5NigQ>? MWrJcohq[mm2aX;uJI9nKGmwZH;s[YFucW6nIEKsN{1lcW:6eXflcoF{\SCrbjDJSm4u\2GvbXGtd5RqdXWuYYTl[EBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGu7boXy[Y5qdmViZn;ycYF1cW:wIHL5JJNx\WO2cn;wbI91d22ndIL5MEBKSzVyPUG5JI5O NEfIOlYyQTVyN{i2Ni=>
mouse B16 cells M4T2bGZ2dmO2aX;uJIF{e2G7 M{P6UWlvcGmkaYTpc44hd2ZiaX7kc4xm[W2rbnWgNkw{NWSrb4j5[4Vv[XOnIHnuJI1wfXOnIFKxOkBk\WyuczDhd5Nme3OnZDDhd{BsgW63cnXubY5mKG[xcn3heIlwdiCkeTDzdIVkfHKxcHjveI9u\XS{eTygTWM2OD12NjDuUS=> NUfxVJFVOTl3MEe4OlI>
mouse P815B clone-6 cells NVvYcVhvTnWwY4Tpc44h[XO|YYm= NVG5PFFJUW6qaXLpeIlwdiCxZjDoeY1idiCLRF:xJJRz[W6|ZnXjeIVlKGmwIH3veZNmKFB6MUXCJINtd26nLU[gZ4VtdHNiYomgTHBNSyCjbnHsfZNqeyxiSVO1NF03OCCwTR?= MoTFNlI3OTZ7MEK=
P815 clone 6 cells MV;GeY5kfGmxbjDhd5NigQ>? NUP0[HdZUW6qaXLpeIlwdiCxZjDtc5V{\SCLRF:xJIlvKFB6MUWgZ4xwdmViNjDj[YxteyCkeTDIVGxEKGGwYXz5d4l{NCCLQ{WwQVAvOSEQvF2= NF7ldIMzOjZzNkmwNi=>
HEK293 clone 6 cells NWfpSXBmTnWwY4Tpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGlFVzFidILhcpNn\WO2ZXSgbY4hUEWNMkmzJINtd26nIE[gZ4VtdHNiYomgTHBNSyCjbnHsfZNqew>? NXnqWnF{OjJ4MU[5NFI>

... Click to View More Cell Line Experimental Data

In vivo In mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) causes dose dependent inhibition of tumor growth. [1] INCB024360 significantly suppresses tumor growth in immunocompetent, but not immunodeficient, mice. [2]


Animal Research:[1]
+ Expand
  • Animal Models: Mice bearing GM-CSF-secreting B16 tumors
  • Formulation: 5% DMA, 47.5% propylene glycol
  • Dosages: 75 mg/kg b.i.d
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 54 mg/mL warmed (198.79 mM)
Ethanol 54 mg/mL warmed (198.79 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 271.64


CAS No. 914471-09-3
Storage powder
in solvent
Synonyms INCB14943

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03516708 Not yet recruiting Rectal Cancer Washington University School of Medicine|Incyte Corporation October 31 2018 Phase 1|Phase 2
NCT02118285 Completed Ovarian Cancer|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma Masonic Cancer Center University of Minnesota|Incyte Corporation July 28 2014 Phase 1
NCT02862457 Recruiting Neoplasms|Carcinoma Non-Small-Cell Lung Merck Sharp & Dohme Corp. August 23 2016 Phase 1
NCT02559492 Active not recruiting Solid Tumors Incyte Corporation November 2015 Phase 1
NCT02318277 Active not recruiting Solid Tumors|Head and Neck Cancer|Lung Cancer|UC (Urothelial Cancer) Incyte Corporation|AstraZeneca December 2014 Phase 1|Phase 2
NCT02298153 Terminated NSCLC (Non-small Cell Lung Carcinoma)|UC (Urothelial Cancer) Incyte Corporation|Hoffmann-La Roche|Genentech Inc. November 2014 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID