BMS-986205

Catalog No.S8629

BMS-986205 Chemical Structure

Molecular Weight(MW): 410.91

BMS-986205 is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

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Choose Selective IDO/TDO Inhibitors

Biological Activity

Description BMS-986205 is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.
Targets
IDO1 [1]
(Cell-free assay)
1.7 nM
In vitro

BMS-986205 exhibits potent inhibition of kynurenine (kyn) production in IDO1-HEK293 cells (IC50 = 1.1 nM) but not in TDO-HEK293 cells[1]. It is an irreversible suicide inhibitor[2].

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.55 mM)
Ethanol 82 mg/mL (199.55 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.91
Formula

C24H24ClFN2O

CAS No. 1923833-60-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03936374 Completed Drug: BMS-986205|Drug: omeprazole Healthy Bristol-Myers Squibb May 8 2019 Phase 1
NCT03362411 Completed Drug: BMS-986205 Healthy Volunteers Bristol-Myers Squibb November 9 2017 Phase 1
NCT03312426 Completed Drug: BMS-986205 Healthy Volunteers Bristol-Myers Squibb October 9 2017 Phase 1
NCT02658890 Recruiting Drug: BMS-986205|Drug: Nivolumab|Drug: Ipilimumab Advanced Cancer|Melanoma|Non-Small Cell Lung Cancer Bristol-Myers Squibb February 18 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID