Epacadostat (INCB024360)

For research use only.

Catalog No.S7910

12 publications

Epacadostat (INCB024360) Chemical Structure

Molecular Weight(MW): 438.23

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).

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Selleck's Epacadostat (INCB024360) has been cited by 12 publications

3 Customer Reviews

  • Macrophages were treated with 2 μM obatoclax, 0.1 μM SNS-032, 3 μM SaliPhe, 0.1 μM JNJ872, 1 μM gemcitabine, 1 μM epacadostat or 1 μM NLG919 or remained non-treated and infected with mock or IAV (moi 3). After 24 h cell viability was measured by CTG and results were plotted. Mean ± SD, n=3.

    FEBS J, 2016, doi: 10.1111/febs.13966.. Epacadostat (INCB024360) purchased from Selleck.

    e Tumor growth kinetics of RIl-175 tumors for control mice, epacadostat, anti-PD-1, or combination therapy of anti-PD-1 and epacadostat. f Tumors weight was recorded as grams (g) of tumor tissue. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

    Cancer Immunol Immunother, 2018, 67(8):1305-1315. Epacadostat (INCB024360) purchased from Selleck.

  • EMT6 cells were treated with miR-18a mimic or miR-18a plus INCB for 48 h; the protein levels were detected immunocytochemistry (n=3) and immunofluorescence (n=3) (B).

    Mol Immunol, 2018, 103:144-155. Epacadostat (INCB024360) purchased from Selleck.

Purity & Quality Control

Choose Selective IDO/TDO Inhibitors

Biological Activity

Description Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
IDO1 [1]
(immune cells)
10 nM
In vitro

In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SKOV-3 cells Mn7GSpVv[3Srb36gZZN{[Xl? MmniTWRQKGmwaHnibZRqd25uIFnDOVB,OTVwMzDuUS=> M2T4blMxOTF{MUC5
Jurkat NE\RNYRE\WyuII\pZYJqdGm2eTDhd5NigQ>? NULLVlRTPzJiaB?= M32wcZJm\HWlZXSgeIhmKG63bXLldkBw\iC4aXHicIUh[2WubIOsJGlEPTBiPTC1NEDPxE1? MUGzNFEyOjFyOR?=

... Click to View More Cell Line Experimental Data

In vivo INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. [1] In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine. [2]


Animal Research:[1] [2]
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  • Animal Models: Female C57BL/6 or Balb/c nu/nu mice bearing PAN02 pancreatic tumors
  • Dosages: ~100 mg/kg, twice a day
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 87 mg/mL (198.52 mM)
Ethanol 53 mg/mL warmed (120.94 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 438.23


CAS No. 1204669-58-8
Storage powder
in solvent
Synonyms N/A
Smiles N[S](=O)(=O)NCCNC1=NON=C1C(NO)=NC2=CC(=C(F)C=C2)Br

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03589651 Recruiting Drug: Retifanlimab|Drug: Epacadostat|Drug: INCB050465 Unresectable or Metastatic Solid Tumors Incyte Corporation July 27 2018 Phase 1
NCT03361228 Completed Drug: INCB001158|Drug: Epacadostat|Drug: Pembrolizumab Solid Tumors Incyte Corporation March 1 2018 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID