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Catalog No. Product Name Information Product Use Citations Product Validations
S0754 Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
Elife, 2021, 10e68473
S1299 Floxuridine (NSC 27640) Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1516 Cidofovir Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
J Virol, 2019, 93(4)
S1878 Ganciclovir (BW 759) Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
Cancer Lett, 2022, 524:131-143
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
Biomed Pharmacother, 2022, 150:112973
S4050 Valganciclovir HCl Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
bioRxiv, 2020, 2020.08.12.246389
Transl Res, 2016, 177:113-126
S4454 FIT-039 FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
S5009 Brivudine Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
S5065 Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).
Cancer Lett, 2022, 524:131-143
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
Cancer Gene Ther, 2022, 10.1038/s41417-022-00431-y
S7296 ML324 ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
Cancer Biol Ther, 2022, 23(1):65-75
Cancer Chemother Pharmacol, 2022, 89(5):643-653
Chem Biol Interact, 2022, 353:109806
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
Oxid Med Cell Longev, 2022, 2022:9523491
Int J Mol Sci, 2021, 22(22)12134
J-Cancer, 2020, 6;11-14-:4047-4058
S8873 Letermovir (AIC246) Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
Antiviral Res, 2021, 189:105062
bioRxiv, 2020, 2020.08.12.246389
S0754 Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
Elife, 2021, 10e68473
S1299 Floxuridine (NSC 27640) Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1516 Cidofovir Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
J Virol, 2019, 93(4)
S1878 Ganciclovir (BW 759) Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
Cancer Lett, 2022, 524:131-143
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
Biomed Pharmacother, 2022, 150:112973
S4050 Valganciclovir HCl Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
bioRxiv, 2020, 2020.08.12.246389
Transl Res, 2016, 177:113-126
S4454 FIT-039 FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
S5009 Brivudine Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
S5065 Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).
Cancer Lett, 2022, 524:131-143
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
Cancer Gene Ther, 2022, 10.1038/s41417-022-00431-y
S7296 ML324 ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
Cancer Biol Ther, 2022, 23(1):65-75
Cancer Chemother Pharmacol, 2022, 89(5):643-653
Chem Biol Interact, 2022, 353:109806
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
Oxid Med Cell Longev, 2022, 2022:9523491
Int J Mol Sci, 2021, 22(22)12134
J-Cancer, 2020, 6;11-14-:4047-4058
S8873 Letermovir (AIC246) Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
Antiviral Res, 2021, 189:105062
bioRxiv, 2020, 2020.08.12.246389
Tags: CMV inhibitor|CMV agonist|CMV activator|CMV inducer|CMV antagonist|CMV signaling pathway|CMV assay kit