CMV

Isoform-selective Products

CMV Products

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  • CMV Inhibitors (12)
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Catalog No. Product Name Information Product Use Citations Product Validations
S1878 Ganciclovir Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
Nat Commun, 2023, 14(1):441
Oral Dis, 2023, 10.1111/odi.14612
Cancer Lett, 2022, 524:131-143
S7296 ML324 ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
Cancer Cell, 2023, 41(6):1118-1133.e12
EBioMedicine, 2023, 92:104602
Viruses, 2023, 15(1)163
S1299 Floxuridine (FUDR) Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
S5065 Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).
Cell Prolif, 2023, 56(5):e13472
Cancer Lett, 2022, 524:131-143
JCI Insight, 2022, 7(14)e158207
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
Antiviral Res, 2022, 207:105416
Oxid Med Cell Longev, 2022, 2022:9523491
Int J Mol Sci, 2021, 22(22)12134
S1516 Cidofovir Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
Antiviral Res, 2019, 162:178-185
S4050 Valganciclovir HCl Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
bioRxiv, 2020, 2020.08.12.246389
Transl Res, 2016, 177:113-126
S8873 Letermovir (AIC246) Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
Antiviral Res, 2021, 189:105062
bioRxiv, 2020, 2020.08.12.246389
S1876 Valaciclovir HCl Valaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).
Sci Adv, 2020, 6(49)eabd9443
S0754 Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
Elife, 2021, 10e68473
E1709New Fialuridine Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.
S5009 Brivudine (BVDU) Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
S1878 Ganciclovir Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
Nat Commun, 2023, 14(1):441
Oral Dis, 2023, 10.1111/odi.14612
Cancer Lett, 2022, 524:131-143
S7296 ML324 ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
Cancer Cell, 2023, 41(6):1118-1133.e12
EBioMedicine, 2023, 92:104602
Viruses, 2023, 15(1)163
S1299 Floxuridine (FUDR) Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cell Chem Biol, 2021, S2451-9456(21)00306-8
S5065 Ganciclovir sodium Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).
Cell Prolif, 2023, 56(5):e13472
Cancer Lett, 2022, 524:131-143
JCI Insight, 2022, 7(14)e158207
S7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
Antiviral Res, 2022, 207:105416
Oxid Med Cell Longev, 2022, 2022:9523491
Int J Mol Sci, 2021, 22(22)12134
S1516 Cidofovir Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
Oncol Lett, 2021, 21(4):280
Nat Biotechnol, 2019, 37(3):303-313
Antiviral Res, 2019, 162:178-185
S4050 Valganciclovir HCl Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.
bioRxiv, 2020, 2020.08.12.246389
Transl Res, 2016, 177:113-126
S8873 Letermovir (AIC246) Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
Antiviral Res, 2021, 189:105062
bioRxiv, 2020, 2020.08.12.246389
S1876 Valaciclovir HCl Valaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).
Sci Adv, 2020, 6(49)eabd9443
S0754 Bisindolylmaleimide IV Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also inhibits PKA with IC50 of 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.
Elife, 2021, 10e68473
E1709New Fialuridine Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.
S5009 Brivudine (BVDU) Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
E1709New Fialuridine Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.

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