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JMJD

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7070 GSK-J4 Hydrochloride GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.
Mol Cell, 2025, 85(15):2973-2987.e6
Nat Cell Biol, 2024, 26(7):1165-1175
J Clin Invest, 2024, 134(24)e173403
Verified customer review of GSK-J4 Hydrochloride
S7281 JIB-04 JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. This compound also induces cell apoptosis.
OncoTargets and Therapy, May 29, 2020, 4833-4842
International Journal of Biological Sciences, June 22, 2018, 1122-1132
The FEBS Journal, August 28, 2025, 396-417
Verified customer review of JIB-04
S8287 CPI-455 HCl CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
Nature, 2023, 622(7983):619-626
Cancer Cell, 2023, 41(6):1118-1133.e12
EBioMedicine, 2023, 92:104602
S7234 IOX1 IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. This compound is an inhibitor of ALKBH5.
bioRxiv, January 03, 2026, 2026.01.03.697470
Scientific Reports, February 03, 2021, 2942
Mol Cell, 2025, 85(15):2973-2987.e6
S7581 GSK J1 GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.
Frontiers in Cell and Developmental Biology, September 08 2021, 702462
Cell Death & Disease, October 28 2020, 927
Journal of Biological Chemistry, May 06 2022, 102017
S7296 ML324 ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
Mol Cell, 2025, 85(15):2973-2987.e6
Cancer Cell, 2023, 41(6):1118-1133.e12
EBioMedicine, 2023, 92:104602
S8601 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
bioRxiv, May 09 2023, nan
Clinical and Molecular Hepatology, 2025, Pending
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
S0201 Z-JIB-04 (NSC 693627) Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
Mol Cell, 2025, 85(15):2973-2987.e6
Molecular Cell, 2025, 2973-2987.e6
Cell Death Discov, 2025, 11(1):326
E1315 iJMJD6 iJMJD6(WL12) is an inhibitor of arginine demethylase JMJD6 with an IC50 value of 0.22 μM.
S4800 Daminozide Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH) is a plant growth regulator that selectively inhibits human KDM2/7 histone demethylases, with IC50 of 0.55 μM for PHF8 (KDM7B), 1.5 μM for KDM2A, and 2.1 μM for KIAA1718 (KDM7A). It shows over 100-fold selectivity for the KDM2/7 subfamily compared to other histone demethylase subfamilies, with significantly weaker activity against enzymes such as KDM3A with IC50 of 127 μM.