PF-06282999

PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.

PF-06282999 Chemical Structure

PF-06282999 Chemical Structure

CAS: 1435467-37-0

Selleck's PF-06282999 has been cited by 1 publication

Purity & Quality Control

Batch: S664801 DMSO] 65 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.65%
99.65

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Choose Selective Peroxidases Inhibitors

Biological Activity

Description PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.
Targets
MPO [1]
(LPS-stimulated human whole blood)
1.9 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01965600 Terminated
Healthy
Pfizer
March 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 325.77 Formula

C13H12ClN3O3S

CAS No. 1435467-37-0 SDF --
Smiles COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (199.52 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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