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Verdiperstat Peroxidases inhibitor

Name: Verdiperstat
Brand: Selleck Chemicals
SKU: S0018
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0018

Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. This compound can be used in the research of neurodegenerative brain disorders.

Chemical Structure

Molecular Weight: 253.32

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Quality Control

Batch: Purity: 99.03%

99.03

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Peroxidases Products	ML 210 ML162 PF-06282999 4-Aminobenzohydrazide ZX703 GPX1/2 Antibody [L20K22] FINO2 JKE-1674 Alkyne tyramide MPO-IN-28

Solubility

In vitro
Batch:

DMSO : 51 mg/mL (201.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	253.32	Formula	C₁₁H₁₅N₃O₂S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	890655-80-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AZD3241, BHV-3241			Smiles	CC(C)OCCN1C2=C(C(=O)NC1=S)NC=C2

Mechanism of Action

Targets/IC₅₀/Ki	MPO (Cell-free assay) 630 nM
References	[1] https://pubmed.ncbi.nlm.nih.gov/25726760/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05184569	Recruiting	Semantic Dementia	Peter Ljubenkov MD\|National Institutes of Health (NIH)\|Alzheimer''s Association\|National Institute on Aging (NIA)\|University of California San Francisco	April 14 2022	Phase 1
NCT00914303	Completed	Healthy	AstraZeneca	June 2009	Phase 1

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