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Technical Data
| Formula | C8H11ClFNO2S |
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| Molecular Weight | 239.69 | CAS No. | 30827-99-7 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (417.2 mM) | |
| Water | 48 mg/mL (200.25 mM) | |||
| Ethanol | 48 mg/mL (200.25 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. | |
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| In vitro | AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. [1] AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. [2] AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. [4] | |
| In vivo | AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. [3] AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. [4] | |
| Features | Broad spectrum, irreversible serine protease inhibitor. |
Protocol (from reference)
| Animal Study:[3] |
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References
Selleck's AEBSF HCl has been cited by 12 publications
| Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] | PubMed: 37705748 |
| Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury [ Int J Biol Sci, 2023, 19(13):4327-4339] | PubMed: 37705748 |
| Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] | PubMed: 36936776 |
| Inhibition of signal peptidase complex expression affects the development and survival of Schistosoma japonicum [ Front Cell Infect Microbiol, 2023, 13:1136056] | PubMed: 36936776 |
| Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts [ Int J Mol Sci, 2021, 22(7)3683] | PubMed: 33916165 |
| Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study [ NMR Biomed, 2021, e4664] | PubMed: 34904305 |
| Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents [ Front Cell Dev Biol, 2020, 8:269] | PubMed: 32500072 |
| Thapsigargin Promotes Colorectal Cancer Cell Migration Through Upregulation of lncRNA MALAT1 [ Oncol Rep, 2020, 43(4):1245-1255] | PubMed: 32323831 |
| Mycoplasma hyopneumoniae inhibits porcine beta-defensin 2 production by blocking the unfolded protein response to facilitate epithelial adhesion and infection. [ Infect Immun, 2020, 20 pii: IAI] | PubMed: 32312764 |
| Mass Spectrometry-Sensitive Probes Coupled with Direct Analysis in Real Time for Simultaneous Sensing of Chemical and Biological Properties of Botanical Drugs [ Anal Chem, 2019, 10.1021/acs.analchem.9b01251] | PubMed: 31246426 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.