Tretinoin

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Cited by 2 Publications

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  • HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.

    Cell, 2018, 175(5):1244-1258. Tretinoin purchased from Selleck.

Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells MV\GeY5kfGmxbjDhd5NigQ>? M{\6S|Mh\GG7cx?= MmD5TY5lfWO2aX;uJI9nKHSncn3pcoFtKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBHQSClZXzsd{Bie3Onc4Pl[EBjgSCvZXHzeZJqdmdic3XjdoV1\WRicHzhd41qdm:pZX6gZYN1cX[jdH;yJIFkfGm4aYT5JIFnfGW{IEOg[IF6eyxiSVO1NF0xNjByMEGg{txO MVOxO|Q5QTV5OR?=
COS7 cells MUHGeY5kfGmxbjDhd5NigQ>? NH7PTI0yPiCq MVjBZ5Rqfmm2eTDheEBpfW2jbjDSRXJo[W2vYTDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIFPPV|ch[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBI[Wx2LVTCSEBie3Onc4Pl[EBieyC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCjZoTldkAyPiCqcoOgZpkhT2GuNDDy[ZNxd26|ZTDlcIVu\W62LXTybZZmdiCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFAzKM7:TR?= NFSzUWYyQTB3OEm2OS=>
CV-1 cells NILoV2RHfW6ldHnvckBie3OjeR?= M1vNfXRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDnZY1u[SxiRVO1NF0xNjByMEeg{txO MV63OFkxPzJ3
human breast cancer cell SK-BR-3 MUHQdo9tcW[ncnH0bY9vKGG|c3H5 NHmyXJZKdmirYnn0bY9vKG:oIFXSMY5m\2G2aY\lJIh2dWGwIHLy[YF{fCClYX7j[ZIh[2WubDDTT{1DWi1|IIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xODF5IN88US=> NIT2OncyOjN5MkWyNC=>
HL-60 cells MYjGeY5kfGmxbjDhd5NigQ>? MXnJcoR2[3Srb36gc4YhfHKjboPncJV1[W2rbnHz[UApXEejc3WpJIFkfGm4aYT5JIlvKEiOLU[wJINmdGy|LDDFR|UxRTBwMEC1JO69VQ>? NUHLWI17QDd6NES1OC=>
human T47D cells M2TBOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoG2OkBl[Xm| MWHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wNFYh|ryP M{DYbVE2PjF3NUKx
mouse NIH3T3 cells M3;h[WZ2dmO2aX;uJIF{e2G7 M1\NSWFkfGm4aYT5JIF1KFKDUnHsdIhiKGW6cILld5Nm\CCrbjDtc5V{\SCQSVizWFMh[2WubIOgZpkhWi2VQWSgZZN{[XluIFXDOVA:OC5yME[zNUDPxE1? NImzVJcyQTJ|OUKzNC=>
Raji cells MUnGeY5kfGmxbjDhd5NigQ>? Mke2OFghcA>? MofwTY5pcWKrdHnvckBw\iCWUFGtbY5lfWOnZDDFdJN1\WmwLVLhdpIhfmm{dYOg[YFzdHliYX70bYdmdiCjY4TpeoF1cW:wIHnuJHJicmliY3XscJMh[W[2ZYKgOFghcHK|LDDJR|UxRTBwMEG1OEDPxE1? MXyxO|UxOzh3MB?=
human MV-4-11 cell NVn6OZBzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\JTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xOjB7OTFOwG0> MYnTRW5ITVJ?
human ATN-1 cell NHXQfY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmq4TY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFMxOyEQvF2= M3n5NXNCVkeHUh?=
HL-60 cells M1HUdmZ2dmO2aX;uJIF{e2G7 MUe0JIRigXN? MlntTY5lfWO2aX;uJI9nKEiOLU[wJINmdGy|IHTp[oZmemWwdHnheIlwdiCxdnXyJFQh\GG7czygSWQ2OD1yLkGyJO69VQ>? M2jOV|k2PzJ6OUO=
human MC-IXC cell NYDBXVUzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{f3UGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPTR|NjFOwG0> M3XNZXNCVkeHUh?=
human HH cell MlHlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGhJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zOUW1OEDPxE1? M2LPbnNCVkeHUh?=
T-47D cells MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 MX7Jcohq[mm2aX;uJI9nKEWUIIDvd4l1cX[nIHj1cYFvKGK{ZXHzeEBk[W6lZYKgZ4VtdCCWLUS3SEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMjFOwG0> MnXvNVI{PzJ3MkC=
human NB13 cell MlXSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4nLXWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlU3PjRizszN NEn0RXVUSU6JRWK=
human D-283MED cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\xNZhTUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK4N21GTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkiyOlIh|ryP NFLlSFhUSU6JRWK=
human HL-60 cell M4ni[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mmn5TY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlg1QTFizszN NGnqOGxUSU6JRWK=
human EW-3 cell Ml\XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGVYNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkS4NFI5KM7:TR?= NWLDWHRPW0GQR1XS
human LNCAP cells Ml7HVJJwdGmoZYLheIlwdiCjc4PhfS=> NWf3WZRuPDhiaB?= NIWze25CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD61JO69VQ>? MUixPVM4PTh{NR?=
human KU812 cell M{LweGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{G1OGlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlU{PjB7IN88US=> NXPU[I1bW0GQR1XS
human MCF7 cells NHn0RYNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYC2JIRigXN? NWLuNGFIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPThizszN MoWyNVU3OTV3MkG=
NB4 cell NV65bZJzTnWwY4Tpc44h[XO|YYm= NHfZSXZKdmS3Y4Tpc44hd2ZiTlK0JINmdGxiZHnm[oVz\W62aXH0bY9vNCCHREWwQVAvPjFizszN MmjoPVU4Ojh7Mx?=
human SK-NEP-1 cell NIDtS2VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH6zXnZKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54NkKzNUDPxE1? MoH5V2FPT0WU
human HCC1806 cell M1i2Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGhESzF6ME[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczQTJ7IN88US=> NYLHfY5ZW0GQR1XS
human T47D cells MoTOR5l1d3SxeHnjxsBie3OjeR?= Ml\0OFghcA>? NFm4bmNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTBwOEKg{txO NXqwVYx2OjV5MEGyOVE>
human HuO-3N1 cell NUTy[2xiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUfnNYJCUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC56M{G2JO69VQ>? MkTIV2FPT0WU
human RPMI-8226 cell NVL4b2U1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOEKyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl|M{Sg{txO MnPCV2FPT0WU
human LAMA-84 cell MoP6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mkf3TY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QTZ|NTFOwG0> MXzTRW5ITVJ?
human NCI-H720 cell NFn0NHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGDXdHhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yMk[yNUDPxE1? MVPTRW5ITVJ?
human MOLT-13 cell NELQenpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH:4dZVKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF2NTFOwG0> MWfTRW5ITVJ?
human JVM-2 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xO|MyPiEQvF2= MUjTRW5ITVJ?
human NBsusSR cell NGWxWJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1QTh5IN88US=> MkXqV2FPT0WU
human BV-173 cell NYjUVG03T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnqfZVoUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV7NkK2JO69VQ>? MYPTRW5ITVJ?
human CTB-1 cell Mn;qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH3YOW1KdmirYnn0bY9vKG:oIHj1cYFvKEOWQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODN6OTFOwG0> NYD6T5N1W0GQR1XS
human ACN cell M1zuWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mny5TY5pcWKrdHnvckBw\iCqdX3hckBCS05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLk[0PVk6KM7:TR?= MUPTRW5ITVJ?
human PC3 cells NWH5V|VNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknXOkBl[Xm| MkDzS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MjFOwG0> M4jaT|E2PjF3NUKx
human L-363 cell M3HtfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MojzTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFY6PjRizszN MnLJV2FPT0WU
human NCI-H69 cell NHmzXYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnzOmhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ4NU[xJO69VQ>? Ml7vV2FPT0WU
human ECC10 cell NVjZNpc5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjhW25MUW6qaXLpeIlwdiCxZjDoeY1idiCHQ1OxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzhyNUKg{txO NWPKc5lHW0GQR1XS
human NCI-H209 cell M1;4Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHfwZYNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53MkGzNkDPxE1? NFnGfXpUSU6JRWK=
human KARPAS-45 cell NWrVRW1CT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3S4ZmlvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQ2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53OUW4NUDPxE1? NIHuNVZUSU6JRWK=
human COR-L88 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wN{45PTh5MjFOwG0> NH\SepJUSU6JRWK=
human ML-2 cell M3[1Rmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVjFVXlxUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4xODR|OTFOwG0> NEHlZmRUSU6JRWK=
human U-266 cell NX\me4F5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEL3d3dKdmirYnn0bY9vKG:oIHj1cYFvKFVvMk[2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yOTh{OTFOwG0> MXjTRW5ITVJ?
human HT-29 cells M1\GU2N6fG:2b4jpZ:Kh[XO|YYm= M3HPVlQ5KGh? M37XeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9OE4{KM7:TR?= NGK5WoIzODRyNUi0PS=>
human RS4-11 cell NUn4dFRQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIDmTXdKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPDR5M{eg{txO MWnTRW5ITVJ?
human DB cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoO1TY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwN{[1NVkh|ryP NFXDe|NUSU6JRWK=
human NB14 cell NX3kb5ZIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M17mcGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNVI4OSEQvF2= MWnTRW5ITVJ?
human BPH-1 cell NVHnc4VFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\STY5pcWKrdHnvckBw\iCqdX3hckBDWEhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOFM3OTFizszN M{\xenNCVkeHUh?=
human PC3 cells MnvnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{Pu[FUh\GG7cx?= MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygS2k2OD15Lk[g{txO MnL3NVg2PDN7MEK=
human EW-13 cell Mn;3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlH4TY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOlExPzhizszN NVfwT|VMW0GQR1XS
human NCI-H526 cell NUfYR41jT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43QDJ7MTFOwG0> NUGybnJtW0GQR1XS
human NKM-1 cell NXfVPYQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYHJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD60NVAxQSEQvF2= NWnaRm1{W0GQR1XS
human MDA-MB-453 cells MWDDfZRwfG:6aXRCpIF{e2G7 NV7DZ2R3PDhiaB?= MoHSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS1N{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhT0l3ME25MlUyKM7:TR?= MXWyOVcxOTJ3MR?=
human MEG-01 cell NXXv[2w6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX3CWFVUUW6qaXLpeIlwdiCxZjDoeY1idiCPRVetNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjZzM{G4JO69VQ>? M{LFWHNCVkeHUh?=
human NCI-H1648 cell NIrYU4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYqwd3R[UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkezOlE4KM7:TR?= M1LkcXNCVkeHUh?=
human LNCaP cells NEnrVpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDBZWpCPiCmYYnz NFroUFFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNVkOjUDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExKM7:TR?= NIrQdoEyPTZzNUWyNS=>
human GP5d cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHPTSZpKdmirYnn0bY9vKG:oIHj1cYFvKEeSNXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4zPjN5IN88US=> NFHCNXFUSU6JRWK=
human MDA-MB-231 cells MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX3xdWhpPSCmYYnz MlOxS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDHTVUxRTFyLki1JO69VQ>? NUiwXWlROTh3NEO5NFI>
human DU145 cells NGrx[FREgXSxdH;4bYPDqGG|c3H5 MlTyOFghcA>? NFj0Tm9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OD1zMT62OEDPxE1? MVmyOVcxOTJ3MR?=
human DEL cell NYS1[lVXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7OW4t{UW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4{PzJ6IN88US=> Mnm3V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
in solvent
Synonyms All-trans Retinoic Acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03999684 Recruiting Drug: Tretinoin Adenoid Cystic Carcinoma Dana-Farber Cancer Institute|The V Foundation|ACCRF August 5 2019 Phase 2
NCT03200847 Recruiting Drug: Pembrolizumab with All-Trans Retinoic Acid Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma University of Colorado Denver|Merck Sharp & Dohme Corp. October 31 2017 Phase 1|Phase 2
NCT02620813 Completed Drug: Tretinoin|Drug: Isotretinoin Acne Vulgaris University of California Davis October 2015 Phase 4
NCT01969058 Completed Drug: Isotretinoin HIV-1 Infection AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) July 2014 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID