For research use only.
Catalog No.S1653 Synonyms: All-trans Retinoic Acid
Molecular Weight(MW): 300.4
Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Selleck's Tretinoin has been cited by 6 publications
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|Description||Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.|
Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis.  Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. 
|In vivo||Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties.  Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy.  Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig.  Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. |
-  Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132.
-  Uchida G, et al. Exp Dermatol, 2003, 12 ,Suppl 2, 35-42.
-  Schwartz E, et al. J Invest Dermatol, 1994, 102(2), 241-246.
|In vitro||DMSO||60 mg/mL (199.73 mM)|
|Ethanol||6 mg/mL (19.97 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||All-trans Retinoic Acid|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03999684||Recruiting||Drug: Tretinoin||Adenoid Cystic Carcinoma||Dana-Farber Cancer Institute|The V Foundation|ACCRF||August 5 2019||Phase 2|
|NCT03200847||Recruiting||Drug: Pembrolizumab with All-Trans Retinoic Acid||Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma||University of Colorado Denver|Merck Sharp & Dohme Corp.||October 31 2017||Phase 1|Phase 2|
|NCT02620813||Completed||Drug: Tretinoin|Drug: Isotretinoin||Acne Vulgaris||University of California Davis||October 2015||Phase 4|
|NCT01969058||Completed||Drug: Isotretinoin||HIV-1 Infection||AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID)||July 2014||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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