Tretinoin (Retinoic acid)

For research use only.

Catalog No.S1653 Synonyms: All-trans Retinoic Acid,ATRA

10 publications

Tretinoin (Retinoic acid) Chemical Structure

CAS No. 302-79-4

Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Selleck's Tretinoin (Retinoic acid) has been cited by 10 publications

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  • HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.

    Cell, 2018, 175(5):1244-1258. Tretinoin (Retinoic acid) purchased from Selleck.

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Biological Activity

Description Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells MoDGSpVv[3Srb36gZZN{[Xl? NVPRdWdPOyCmYYnz NUO0O3BDUW6mdXP0bY9vKG:oIITldo1qdmGuIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCIOTDj[YxteyCjc4Pld5Nm\CCkeTDt[YF{fXKrbnegd4VkemW2ZXSgdIxie22rbn;n[Y4h[WO2aY\heI9zKGGldHn2bZR6KGGodHXyJFMh\GG7czygTWM2OD1yLkCwNFEh|ryP NHK4So4yPzR6OUW3PS=>
COS7 cells MnjZSpVv[3Srb36gZZN{[Xl? M1u4RlE3KGh? NWLjTYNGSWO2aY\peJkh[XRiaIXtZY4hWkGUZ3HtcYEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1FSkRiYYPz[ZN{\WRiYYOgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZYZ1\XJiMU[gbJJ{KGK7IFfhcFQhemW|cH;ud4Uh\WynbXXueE1lemm4ZX6gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODByMjFOwG0> MUWxPVA2QDl4NR?=
CV-1 cells MnrDSpVv[3Srb36gZZN{[Xl? M1XJN3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDnZY1u[SxiRVO1NF0xNjByMEeg{txO NFPLW3Q4PDlyN{K1
human breast cancer cell SK-BR-3 MnLVVJJwdGmoZYLheIlwdiCjc4PhfS=> NF7XZm1KdmirYnn0bY9vKG:oIFXSMY5m\2G2aY\lJIh2dWGwIHLy[YF{fCClYX7j[ZIh[2WubDDTT{1DWi1|IIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xODF5IN88US=> M1qzU|EzOzd{NUKw
HL-60 cells NFy0SnJHfW6ldHnvckBie3OjeR?= NWSxXXJGUW6mdXP0bY9vKG:oIITyZY5{\2y3dHHtbY5ie2ViKGTHZZNmMSCjY4Tpeol1gSCrbjDIUE03OCClZXzsd{whTUN3ME2wMlAxPSEQvF2= NF;GV|Q5Pzh2NEW0
human T47D cells M1zn[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXuUGx{PiCmYYnz NI\sOXBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE4xODZizszN MWCxOVYyPTV{MR?=
mouse NIH3T3 cells NX7keYJWTnWwY4Tpc44h[XO|YYm= MoPaRYN1cX[rdImgZZQhWkGUYXzwbIEh\XiycnXzd4VlKGmwIH3veZNmKE6LSEPUN{Bk\WyuczDifUBTNVODVDDhd5NigSxiRVO1NF0xNjByNkOxJO69VQ>? M{nwOFE6OjN7MkOw
Raji cells MlnVSpVv[3Srb36gZZN{[Xl? MYS0PEBp MV\Jcohq[mm2aX;uJI9nKFSSQT3pcoR2[2WmIFXwd5RmcW5vQnHydkB3cXK3czDlZZJtgSCjboTp[4VvKGGldHn2ZZRqd25iaX6gVoFrcSClZXzsd{Bi\nSncjC0PEBpenNuIFnDOVA:OC5yMUW0JO69VQ>? M13KTVE4PTB|OEWw
human MV-4-11 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzwcYxYUW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMkC5PUDPxE1? NHT6UmtUSU6JRWK=
human ATN-1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37aPWlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA{ODNizszN NVHHbWJ3W0GQR1XS
HL-60 cells MnHGSpVv[3Srb36gZZN{[Xl? M1GxXFQh\GG7cx?= M1fTb2lv\HWldHnvckBw\iCKTD22NEBk\WyuczDkbYZn\XKnboTpZZRqd25ib4\ldkA1KGSjeYOsJGVFPTB;MD6xNkDPxE1? NIn3Ook6PTd{OEmz
human MC-IXC cell M2fiTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{GzeWlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPTR|NjFOwG0> MmriV2FPT0WU
human HH cell MmCyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEC2bYZKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPVU2PCEQvF2= NUmyfINHW0GQR1XS
T-47D cells MkjsVJJwdGmoZYLheIlwdiCjc4PhfS=> MWLJcohq[mm2aX;uJI9nKEWUIIDvd4l1cX[nIHj1cYFvKGK{ZXHzeEBk[W6lZYKgZ4VtdCCWLUS3SEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMjFOwG0> NXW4UXhzOTJ|N{K1NlA>
human NB13 cell M4XwOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG5DOTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkK1OlY1KM7:TR?= M2K4SXNCVkeHUh?=
human D-283MED cell MnjwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGW2N2lKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{OEK2NkDPxE1? MXPTRW5ITVJ?
human HL-60 cell NIXHXI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPFQ6OSEQvF2= MWDTRW5ITVJ?
human EW-3 cell MnzqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI\LTWxKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlQ5ODJ6IN88US=> MX\TRW5ITVJ?
human LNCAP cells MWjQdo9tcW[ncnH0bY9vKGG|c3H5 Mm\QOFghcA>? MlzaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNTFOwG0> M2PkTVE6Ozd3OEK1
human KU812 cell NH7FcWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;jU4Y3UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTN4MEmg{txO Ml;TV2FPT0WU
human MCF7 cells M2HNeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fublYh\GG7cx?= MVzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD61PEDPxE1? NV[5W29POTV4MUW1NlE>
NB4 cell MXrGeY5kfGmxbjDhd5NigQ>? MX\JcoR2[3Srb36gc4YhVkJ2IHPlcIwh\GmoZnXy[Y51cWG2aX;uMEBGTDVyPUCuOlEh|ryP MoDDPVU4Ojh7Mx?=
human SK-NEP-1 cell M1PBfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlHrTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjZ{M{Gg{txO M3\NdHNCVkeHUh?=
human HCC1806 cell M1jI[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fidGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUiwOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ7Mkmg{txO MkjNV2FPT0WU
human T47D cells NFTQVldEgXSxdH;4bYPDqGG|c3H5 MnG0OFghcA>? M1TTOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFfJOVA:OC56MjFOwG0> MYWyOVcxOTJ3MR?=
human HuO-3N1 cell MnTzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV[4bZBLUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC56M{G2JO69VQ>? Mle1V2FPT0WU
human RPMI-8226 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDJd3ZKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFIzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUmzN|Qh|ryP M{LXdnNCVkeHUh?=
human LAMA-84 cell M2fPOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{L0d2lvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl4M{Wg{txO M2n0WnNCVkeHUh?=
human NCI-H720 cell MmDjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjkUYdzUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEK2NlEh|ryP MoDOV2FPT0WU
human MOLT-13 cell NGXLTmFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1PSEQvF2= MWfTRW5ITVJ?
human JVM-2 cell M37Me2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXTlfZFoUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTd|MU[g{txO NIfjPZRUSU6JRWK=
human NBsusSR cell NIjMUZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnvWTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDl6NzFOwG0> M1nB[nNCVkeHUh?=
human BV-173 cell Mk\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVk3OjZizszN NGPWVW9USU6JRWK=
human CTB-1 cell NWPiSXJiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62NFM5QSEQvF2= NIjubYZUSU6JRWK=
human ACN cell Mn7tS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGGwPGtKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlQ6QTlizszN NEjIfXVUSU6JRWK=
human PC3 cells MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHqfYo3KGSjeYO= NYjzXG51T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NkDPxE1? NXfaUZQzOTV4MUW1NlE>
human L-363 cell NEHyXnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fBSGlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA3QTZ2IN88US=> NGPmWm1USU6JRWK=
human NCI-H69 cell NWS3S4RwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI3PTZzIN88US=> NVPiV3pDW0GQR1XS
human ECC10 cell M3:3fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn25TY5pcWKrdHnvckBw\iCqdX3hckBGS0NzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|gxPTJizszN Mk\1V2FPT0WU
human NCI-H209 cell MmTIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF\qS4ZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53MkGzNkDPxE1? NHnqUW1USU6JRWK=
human KARPAS-45 cell Ml7GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;KTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV7NUixJO69VQ>? M17lbXNCVkeHUh?=
human COR-L88 cell NXz1do82T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4jxVWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVy4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVA{Njh3OEeyJO69VQ>? NHvjNmxUSU6JRWK=
human ML-2 cell NVGwN2w1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4\GSWlvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNFA1OzlizszN NG\tTXBUSU6JRWK=
human U-266 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfUTY5pcWKrdHnvckBw\iCqdX3hckBWNTJ4NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVE5OjlizszN M17UTXNCVkeHUh?=
human HT-29 cells NED2WpVEgXSxdH;4bYPDqGG|c3H5 NWjjdmU5PDhiaB?= MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUSuN{DPxE1? M{m0N|IxPDB3OES5
human RS4-11 cell NXjhTJd3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zQS2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41PDd|NzFOwG0> NV7vemFPW0GQR1XS
human DB cell M37QWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC55NkWxPUDPxE1? MWnTRW5ITVJ?
human NB14 cell NFWzTlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLJTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6xNlcyKM7:TR?= MVXTRW5ITVJ?
human BPH-1 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGJRUC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz60N|YyOSEQvF2= Mmr2V2FPT0WU
human PC3 cells NH3BUmFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoPqOUBl[Xm| NYHxRXB1T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEeLNUC9O{43KM7:TR?= MUKxPFU1OzlyMh?=
human EW-13 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkLtTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOlExPzhizszN MUPTRW5ITVJ?
human NCI-H526 cell Mm\XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NILGVWhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54OEK5NUDPxE1? M2T3dHNCVkeHUh?=
human NKM-1 cell MmrJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD60NVAxQSEQvF2= NFHkd4VUSU6JRWK=
human MDA-MB-453 cells M2LuemN6fG:2b4jpZ:Kh[XO|YYm= M3jtWFQ5KGh? NVXveHc{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ2OyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF06NjVzIN88US=> MojDNlU4ODF{NUG=
human MEG-01 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\oXVAxUW6qaXLpeIlwdiCxZjDoeY1idiCPRVetNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjZzM{G4JO69VQ>? NEXMc4hUSU6JRWK=
human NCI-H1648 cell NYnEV2tXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{\POWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS55M{[xO{DPxE1? NYPMOXQ6W0GQR1XS
human LNCaP cells NGDXbGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NE\Od|E3KGSjeYO= NELj[VhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNVkOjUDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExKM7:TR?= NX[yUlVCOTV4MUW1NlE>
human GP5d cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGdRPWRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD6yOlM4KM7:TR?= MWTTRW5ITVJ?
human MDA-MB-231 cells NXT6XIx6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGG0dIE2KGSjeYO= M2PmUmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygS2k2OD1zMD64OUDPxE1? MWGxPFU1OzlyMh?=
human DU145 cells MUjDfZRwfG:6aXRCpIF{e2G7 Moi1OFghcA>? NGLWN4ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OD1zMT62OEDPxE1? NH63[5YzPTdyMUK1NS=>
human DEL cell M1GyW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlmwTY5pcWKrdHnvckBw\iCqdX3hckBFTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6zO|I5KM7:TR?= MoDRV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Water Insoluble
Ethanol ''''6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms All-trans Retinoic Acid,ATRA
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04149418 Not yet recruiting Other: Yogurt|Other: Control food Obesity|Inflammation University of Wisconsin Madison|National Dairy Council|University of Massachusetts Amherst January 2021 Not Applicable
NCT03327064 Not yet recruiting Drug: UAB30|Drug: Placebo Non-melanoma Skin Cancer University of Alabama at Birmingham August 15 2020 Phase 1|Phase 2
NCT03999684 Completed Drug: Tretinoin Adenoid Cystic Carcinoma Dana-Farber Cancer Institute|The V Foundation|ACCRF August 5 2019 Phase 2
NCT03611595 Recruiting Drug: Cabozantinib|Drug: 13-cis-retinoic acid Solid Tumor Peter Zage|Exelixis|University of California San Diego August 28 2018 Phase 1
NCT03200847 Active not recruiting Drug: Pembrolizumab with All-Trans Retinoic Acid Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma University of Colorado Denver|Merck Sharp & Dohme Corp. October 31 2017 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID