Tretinoin (NSC 122758)

For research use only.

Catalog No.S1653 Synonyms: Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A

13 publications

Tretinoin (NSC 122758) Chemical Structure

CAS No. 302-79-4

Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Tretinoin (NSC 122758) has been cited by 13 publications

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  • HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.

    Cell, 2018, 175(5):1244-1258. Tretinoin (NSC 122758) purchased from Selleck.

Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human breast cancer cell SK-BR-3 MlTKVJJwdGmoZYLheIlwdiCjc4PhfS=> MmC3TY5pcWKrdHnvckBw\iCHUj3u[YdifGm4ZTDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGxiU1utRnIuOyCycn;sbYZmemG2aX;uMEBKSzVyPUCuNFAyPyEQvF2= NXvCe3Q2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKzO|I2OjBpPkGyN|czPTJyPD;hQi=>
T-47D cells MUXQdo9tcW[ncnH0bY9vKGG|c3H5 MYrJcohq[mm2aX;uJI9nKEWUIIDvd4l1cX[nIHj1cYFvKGK{ZXHzeEBk[W6lZYKgZ4VtdCCWLUS3SEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMjFOwG0> MnPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ|N{K1NlAoRjF{M{eyOVIxRC:jPh?=
F9 Mn7mSpVv[3Srb36gZZN{[Xl? NHrm[ldC[mmuaYT5JJRwKGSrc4DsZYNmKDNidV2gdoV1cW6xaXSgZY5lKFt|SG3hcIwufHKjboOtdoV1cW6xaXOgZYNq\CCrbjDGPUBmdWK{eX;uZYwh[2G{Y3nuc41iKGOnbHzzJJV{cW6pIF[5JHBt[XOvaX7v[4VvKEGldHn2ZZRweiC{ZXzlZZNqdmdiYYPzZZktKEWGNUC9NE4xODBzzszN NXPXbpNXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezPFg5PSd-MkezPFg5PTxxYU6=
F9 MWHGeY5kfGmxbjDhd5NigQ>? M4LZOWFjcWyrdImgeI8h\Gm|cHzhZ4UhYzOKXXHscE11emGwcz3y[ZRqdm:rYzDhZ4llKG[{b32gSlkh\W2kconvcoFtKGOjcnPpco9u[SClZXzsd{whf2G|IHHzd4V{e2WmIHnuJIEhTjlibHHtbY5qdiC{ZXzlZZNmKGG|c3H5MEBGTDVyPUCuNFAyPc7:TR?= M1L5W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{i4PFUoRjJ5M{i4PFU9N2F-
ASK MWfGeY5kfGmxbjDhd5NigQ>? MmO2NUBpeg>? NVniTnk4UW6mdXP0bY9vKG:oIH3vdpBpd2yxZ3njZYwhfHKjboPmc5Ju[XSrb36gc4YhemG2IFHTT{Bk\WyuczDpcpRwKGG|dILvZ5l1\XNiYX\0[ZIhOSCqcjDifUBtcWeqdDDtbYNzd3Olb4D5MEBGTDVyPUGw{txO NX3Hd5Y3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PVY1OSd-Mki0PVY1OTxxYU6=
CV-1 M1jTZmZ2dmO2aX;uJIF{e2G7 NH;ibFdVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMEC3{txO MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PDlyN{K1K|44PDlyN{K1QE9iRg>?
CV-1 M33XXWZ2dmO2aX;uJIF{e2G7 MUPUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUnX0bY5wcWNiYXPp[EBz\WOncITvdkBTSVJiYnX0ZUwhTUN3ME2wMlAxOc7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PDlyN{K1K|44PDlyN{K1QE9iRg>?
CV-1 MVvGeY5kfGmxbjDhd5NigQ>? MlPWWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLleIlvd2mlIHHjbYQhemWlZYD0c5IhWkGUIHHsdIhiNCCHQ{WwQVAvODB5zszN M16wVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd2OUC3NlUoRjd2OUC3NlU9N2F-
HL-60 cdm-1 MWXGeY5kfGmxbjDhd5NigQ>? NHnwb4RVemGwc3fseZRidWmwYYPlJIFkfGm4aYT5JIlvKEiOLU[wJINldS1zIHPlcIx{NCCHQ{WwQVAvODB3zszN M{LqN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd4M{[4OFMoRjd4M{[4OFM9N2F-
mouse embryo limb bud cells MnXkSpVv[3Srb36gZZN{[Xl? NYjCcXoxUW5idnn0do8hcW6qaXLpeIlwdiCxZjDjbI9v\HKxZ3Xu[ZNqeyCrbjDtc5V{\SCnbXLyfY8hdGmvYjDieYQh[2WubIOsJGlEPTB;MD6wN|HPxE1? NELxPGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NkO2PFQ{Lz55NkO2PFQ{RC:jPh?=
leukemia cells NHnlRmFHfW6ldHnvckBie3OjeR?= Mne4WIhmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEB1cGViYnnu[Ilv\yCxZjDbN2heSVSUQTD0c{Bz\XSrbn;pZ{Bi[2mmIILlZ4VxfG:{IHnuJIh2dWGwIIDyc416\WyxY4n0bYMhdGW3a3XtbYEh[2WubIOsJGlEPTB;MD6wNFA3O87:TR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PjN4OEe5K|44PjN4OEe5QE9iRg>?
CV-1 M2HP[2Z2dmO2aX;uJIF{e2G7 MYjCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RicnX0bY5wcWNiQXPp[EBo[W2vYTDy[YNmeHSxcoOgZ48ufHKjboPm[YN1\WRiaX70c{BEXi1zIHPlcIx{NCCHQ{WwQVAvODIQvF2= NUO2dVByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEOwPFg3Pyd-OEOwPFg3PzxxYU6=
CV-1 MV;GeY5kfGmxbjDhd5NigQ>? NYjvNWR6SmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JJJmfGmwb3njJGFkcWRiYnX0ZUBz\WOncITvdpMh[29vdILhcpNn\WO2ZXSgbY51dyCFVj2xJINmdGy|LDDFR|UxRTBwMElOwG0> NYPqS5FnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEOwPFg3Pyd-OEOwPFg3PzxxYU6=
CV-1 NWrWV|lPTnWwY4Tpc44h[XO|YYm= MUHCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RicnX0bY5wcWNiQXPp[EBidHCqYTDy[YNmeHSxcoOgZ48ufHKjboPm[YN1\WRiaX70c{BEXi1zIHPlcIx{NCCHQ{WwQVAvOzYQvF2= NXzlblJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEOwPFg3Pyd-OEOwPFg3PzxxYU6=
CV-1 NY\5NW4yTnWwY4Tpc44h[XO|YYm= NVX3cFJ[SmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JJJmfGmwb3njJGFkcWRiWDDhcJBp[SC{ZXPldJRwenNiY3:teJJidnOoZXP0[YQhcW62bzDDWk0yKGOnbHzzMEBGSzVyPUCuPe69VQ>? M4LyR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh|MEi4OlcoRjh|MEi4Olc9N2F-
CV-1 MkHDSpVv[3Srb36gZZN{[Xl? M2P3c2JqdmSrbnegZYZncW6rdImgZYdicW6|dDDy[ZRqdm:rYzDBZ4llKFhiZ3HtcYEhemWlZYD0c5J{KGOxLYTyZY5{\mWldHXkJIlvfG9iQ2[tNUBk\WyuczygSWM2OD1zLkJOwG0> MkjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDNyOEi2O{c,QDNyOEi2O|ww[T5?
CV-1 NFrZNVlHfW6ldHnvckBie3OjeR?= NXfiS457SmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JJJmfGmwb3njJGFkcWRiWDDi[ZRiKHKnY3XweI9zeyClbz30doFve2[nY4Tl[EBqdnSxIFPWMVEh[2WubIOsJGVEPTB;MT60{txO NHjxR2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96M{C4PFY4Lz56M{C4PFY4RC:jPh?=
F9 M37zXmZ2dmO2aX;uJIF{e2G7 Mk\ETY4hfmm2cn:gdJJwdW:2aX;uJI9nKHCuYYPtbY5w\2WwIHHjeIl3[XSxcjDz[YNz\XSrb36g[pJwdSCIOTCocZVzcW6nIITldoF1d2OjcnPpco9u[SliY3XscJMtKEGFNUC9NE4z|ryP NGXFR4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NUS0NVc2Lz56NUS0NVc2RC:jPh?=
CV-1 M1[2cWZ2dmO2aX;uJIF{e2G7 Mli4WJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLleIlvd2mlIHHjbYQhemWlZYD0c5IhWkGUIHfhcY1iNCCHQ{WwQVAvODN|zszN M1fpe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5MEmwPVQoRjh5MEmwPVQ9N2F-
CV-1 Mn7zSpVv[3Srb36gZZN{[Xl? NHXLXVBVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKgZoV1[SxiRVO1NF0xNjFyNd88US=> NETSOIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96N{C5NFk1Lz56N{C5NFk1RC:jPh?=
CV-1 MnLTSpVv[3Srb36gZZN{[Xl? MVPUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUnX0bY5wcWNiYXPp[EBz\WOncITvdkBTSVJiYXzwbIEtKEWFNUC9NE42PjQQvF2= NVrrSVl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEewPVA6PCd-OEewPVA6PDxxYU6=
CV-1 M1\HV2Z2dmO2aX;uJIF{e2G7 NV\GN3RvXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJmfGmwb3nkJHghemWlZYD0c5IhWliUIHHsdIhiNCCHQ{WwQVEvODh2zszN MonQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDdyOUC5OEc,QDdyOUC5OFww[T5?
CV-1 NFjCOIJHfW6ldHnvckBie3OjeR?= NVj3WpNqXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJmfGmwb3nkJHghemWlZYD0c5IhWliUIHfhcY1iNCCHQ{WwQVEvOjJ3zszN NWLKfnBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEewPVA6PCd-OEewPVA6PDxxYU6=
CV-1 MWfGeY5kfGmxbjDhd5NigQ>? NGTybWRVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXSgXEBz\WOncITvdkBTYFJiYnX0ZUwhTUN3ME2xMlM6PM7:TR?= NE\6T|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96N{C5NFk1Lz56N{C5NFk1RC:jPh?=
HL-60 NIDwfHNHfW6ldHnvckBie3OjeR?= Mof4TY5lfWO2aX;uJI9nKHS{YX7z[4x2fGGvaX7hd4UhMFSJYYPlLUBi[3Srdnn0fUBqdiCKTD22NEBk\WyuczygSWM2OD1yLkCwOe69VQ>? NIXvZng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96N{i0OFU1Lz56N{i0OFU1RC:jPh?=
embryonic limb bud cells NHSzVINHfW6ldHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKEOqb37kdo9o\W6nc3nzJIlvKGSjeTCxNUBmdWK{eX;ubYMhdGmvYjDieYQh[2WubIOsJGlEPTB;MD6wN|HPxE1? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85Pzh2NEW0K|45Pzh2NEW0QE9iRg>?
CV-1 NGHJXFNHfW6ldHnvckBie3OjeR?= NHfuPIdVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMt88US=> M1LxbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh7N{i4N|IoRjh7N{i4N|I9N2F-
CV-1 NH;CUm5HfW6ldHnvckBie3OjeR?= NHrWVZhVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKgZoV1[SxiRVO1NF0xNjB6N988US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85QTd6OEOyK|45QTd6OEOyQE9iRg>?
CV-1 NXy0UldKTnWwY4Tpc44h[XO|YYm= M1X3enRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDhcJBp[SxiRVO1NF0xNjR3Od88US=> NH\mTm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96OUe4PFMzLz56OUe4PFMzRC:jPh?=
CV-1 NVKzeZNoTnWwY4Tpc44h[XO|YYm= Ml34WJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIILleIlvd2mmIFGgdoVk\XC2b4KgVmFTKGKndHGsJGVEPTB;MD6wNFLPxE1? NULJXFJSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW3Nlg6Oyd-OUW3Nlg6OzxxYU6=
CV-1 NXzp[Y1WTnWwY4Tpc44h[XO|YYm= MVHUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdicnX0bY5wcWRiWDDy[YNmeHSxcjDSXHIh\2GvbXGsJGVEPTB;MD6wNFbPxE1? M1rFOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3N{K4PVMoRjl3N{K4PVM9N2F-
CV-1 Mki0SpVv[3Srb36gZZN{[Xl? NILUb5VVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegdoV1cW6xaXSgRUBz\WOncITvdkBTSVJiYXzwbIEtKEWFNUC9NE4xOjMQvF2= NX3rXIJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW3Nlg6Oyd-OUW3Nlg6OzxxYU6=
HL-60 MYPGeY5kfGmxbjDhd5NigQ>? NUmweY9[UW6mdXP0bY9vKG:oIFjMMVYxKGOnbHzzJIRq\m[ncnXueIlifGmxbjDveoVzKDRiZHH5d{whTUR3ME2wMlEz|ryP M1\pNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3N{K4PVMoRjl3N{K4PVM9N2F-
HL-60 M2riV2N6fG:|dHH0bYMh[XO|YYm= NF;MfFlEgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhUExvNkCgZ4VtdHNuIFnDOVA:OTIQvF2= NFfkeVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW4OVIxPid-MUC1PFUzODZ:L3G+
CV-1 M1;Dc2Z2dmO2aX;uJIF{e2G7 MXjUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUlHSJIdidW2jIILlZ4VxfG:{LDDFR|MxRTBwMECwNlLPxE1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODd4MkCzPEc,OTB5NkKwN|g9N2F-
CV-1 NUnhS4NjTnWwY4Tpc44h[XO|YYm= M1HtSHRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDSRXIh[mW2YTDy[YNmeHSxcjygSWM{OD1yLkCwNFk{|ryP M37lblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{[yNFM5Lz5zMEe2NlA{QDxxYU6=
CV-1 Mk\BSpVv[3Srb36gZZN{[Xl? MWjUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUlHSJIFteGijIILlZ4VxfG:{LDDFR|MxRTBwMECwPVnPxE1? NYO2S45LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC3OlIxOzhpPkGwO|YzODN6PD;hQi=>
CV-1 MnX1SpVv[3Srb36gZZN{[Xl? NXnJSXo5WmWuYYTpeoUhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCjbIDoZUBz\WOncITvdkBkd22yYYLl[EB1dyCDVGLBMEBT\WyjdHn2[UBGSzNyPUCuNFAy|ryP NXfVSXVxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC3OlIxOzhpPkGwO|YzODN6PD;hQi=>
CV-1 MlfvSpVv[3Srb36gZZN{[Xl? NXHsfJVFWmWuYYTpeoUhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCkZYThJJJm[2WydH;yJINwdXCjcnXkJJRwKEGWUlGsJHJmdGG2aY\lJGVEOzB;MD6wNFHPxE1? NHn3WmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEe2NlA{QCd-MUC3OlIxOzh:L3G+
CV-1 MXLGeY5kfGmxbjDhd5NigQ>? NXjy[GdQWmWuYYTpeoUhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCpYX3tZUBz\WOncITvdkBkd22yYYLl[EB1dyCDVGLBMEBT\WyjdHn2[UBGSzNyPUCuNFAy|ryP NE\2cGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEe2NlA{QCd-MUC3OlIxOzh:L3G+
CV-1 NVrLbGR2TnWwY4Tpc44h[XO|YYm= MVfUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUlHSJIdidW2jIILlZ4VxfG:{LDDFR|MxRTBwMECwNVjPxE1? Mom5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5NkKwN|koRjFyN{[yNFM6RC:jPh?=
CV-1 NGXnPYRHfW6ldHnvckBie3OjeR?= NIPYcFhVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVmFTKGKndHGgdoVk\XC2b4KsJGVEOzB;MD6wNFA3Qc7:TR?= NViwWZg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC3OlIxOzlpPkGwO|YzODN7PD;hQi=>
CV-1 NYDmemczTnWwY4Tpc44h[XO|YYm= MUHUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUlHSJIFteGijIILlZ4VxfG:{LDDFR|MxRTBwMECxNe69VQ>? M3u3OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{[yNFM6Lz5zMEe2NlA{QTxxYU6=
COS M2PWeWZ2dmO2aX;uJIF{e2G7 NF;4XnNVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFT2OgZ4VtdHNiZYjwdoV{e2mwZzDSRXIu\2GvbXGsJHJmdGG2aY\lJGVEOzB;MD6wNFAzPs7:TR?= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODl3NkKwNUc,OTB7NU[yNFE9N2F-
COS NEnlZmxHfW6ldHnvckBie3OjeR?= M4nr[HRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEORUzDj[YxteyCneIDy[ZN{cW6pIGLBVk1j\XSjLDDS[YxifGm4ZTDFR|MxRTBwMECyNu69VQ>? M3:4ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUW2NlAyLz5zMEm1OlIxOTxxYU6=
COS MYnGeY5kfGmxbjDhd5NigQ>? NXPqe4t{XHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ1;TJINmdGy|IHX4dJJme3OrbnegVmFTNWGucHjhMEBT\WyjdHn2[UBGSzNyPUCuNFA{PM7:TR?= M3nQOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUW2NlAyLz5zMEm1OlIxOTxxYU6=
HL60 MWHGeY5kfGmxbjDhd5NigQ>? MYXJckB3cXS{bzDjfZRwfG:6aXPpeJkh[WejaX7zeEBJVDZyIHPlcIx{NCCLQ{WwQVEy|ryP Mo\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFzMki2OFgoRjFzMUK4OlQ5RC:jPh?=
CV-1 NIHVbW5HfW6ldHnvckBie3OjeR?= Ml\vWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKFKndHnuc4lkKGGlaXSgdoVk\XC2b4KgVmFTKGejbX3hMEBGSzVyPUCuNFE6|ryP M2WzZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NEiyOFM2Lz5zMkS4NlQ{PTxxYU6=
CV-1 MoHzSpVv[3Srb36gZZN{[Xl? MnPaWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKFKndHnuc4lkKGGlaXSgdoVk\XC2b4KgVmFTKGKndHGsJGVEPTB;MD6wO|jPxE1? NUe4V|c3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0PFI1OzVpPkGyOFgzPDN3PD;hQi=>
CV-1 M33qc2Z2dmO2aX;uJIF{e2G7 MmrrWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKFKndHnuc4lkKGGlaXSgdoVk\XC2b4KgVmFTKGGucHjhMEBGSzVyPUCuOFM3|ryP MofNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2OEK0N|UoRjF{NEiyOFM2RC:jPh?=
CV-1 NFzPWI1HfW6ldHnvckBie3OjeR?= M3nkR3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDtc5V{\SCUZYTpco9q\CC[IILlZ4VxfG:{IGLYVkBo[W2vYTygSWM2OD1yLkm2Ne69VQ>? MlfzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2OEK0N|UoRjF{NEiyOFM2RC:jPh?=
CV-1 MmPnSpVv[3Srb36gZZN{[Xl? MVTUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiaIXtZY4hWmW2aX7vbYQhYCC{ZXPldJRweiCUWGKtZYxxcGFuIFXDOVA:OS5yMUZOwG0> NEDOcXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS4NlQ{PSd-MUK0PFI1OzV:L3G+
CV-1 MULGeY5kfGmxbjDhd5NigQ>? MW\UdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdibX;1d4UhWmW2aX7vbYQhYCC{ZXPldJRweiCUWGKgZoV1[SxiRVO1NF0yNjJzMd88US=> M1\HTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NEiyOFM2Lz5zMkS4NlQ{PTxxYU6=
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MCF7 NYTsUpp7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVK2JIRigXN? NX;LT3F4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTkQvF2= M1fTZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkG1OVIyLz5zNU[xOVUzOTxxYU6=
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HaCaT MoXTSpVv[3Srb36gZZN{[Xl? M4rzcmlv[3KnYYPlJIlvKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUBw\iCUQWLhcJBp[SC{ZXPldJRweiCncILld5Nm\CCrbjDoeY1idiCKYVPhWEBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJGRTPS22az3DRXQhemWyb4L0[ZIheGyjc33p[EBie3Onc4Pl[EBieyCkZYThMYdidGGldH;zbYRie2ViYXP0bZZqfHliYomgR2FVNUWOSWPB MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVzMUK4N{c,OTh3MUGyPFM9N2F-
PC3 MlvLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;JOUBl[Xm| MWPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygS2k2OD15LkdOwG0> M3fUdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUSzPVAzLz5zOEW0N|kxOjxxYU6=
MDA-MB-231 NX3DV4hUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2LoSlUh\GG7cx?= M361RWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygS2k2OD1zMD64Oe69VQ>? M1zIR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUSzPVAzLz5zOEW0N|kxOjxxYU6=
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CV-1 M1TSfmZ2dmO2aX;uJIF{e2G7 NUnHVVNGS2:vcH;1coQhf2G|IITld5Rm\CCob4Kg[pVv[3Srb37hcEBi[3Srdnn0fUBqdiCFVj2xJINmdGy|IITyZY5{\mWldHXkJJdqfGhiYX6g[ZhxemW|c3nvckB3\WO2b4Kg[o9zKHKndHnuc4lkKGGlaXSgdoVk\XC2b4Kg[4FudWFidYPpcochfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMECwO:69VQ>? NYDje5hJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzhxJ{7DbGVOSkx:L3G+
CV-1 NGPaSYpHfW6ldHnvckBie3OjeR?= NH7BVHdEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDmeY5kfGmxbnHsJIFkfGm4aYT5JIlvKEOYLUGgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCjbjDlfJBz\XO|aX;uJJZm[3SxcjDmc5IhemW2aX7vbYMh[WOrZDDy[YNmeHSxcjDi[ZRiKHW|aX7nJJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjByMd88US=> NWrre5hPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzhxJ{7DbGVOSkx:L3G+
CV-1 NX3HXGUxTnWwY4Tpc44h[XO|YYm= NUfFW5BoS2:vcH;1coQhf2G|IITld5Rm\CCob4Kg[pVv[3Srb37hcEBi[3Srdnn0fUBqdiCFVj2xJINmdGy|IITyZY5{\mWldHXkJJdqfGhiYX6g[ZhxemW|c3nvckB3\WO2b4Kg[o9zKHKndHnuc4lkKGGlaXSgdoVk\XC2b4KgZYxxcGFidYPpcochfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMEC3{txO NIP0Nnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{QC9pPlPoSW1DVDxxYU6=
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CV-1 MmS3SpVv[3Srb36gZZN{[Xl? NIjNeIlEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDmeY5kfGmxbnHsJIFkfGm4aYT5JIlvKEOYLUGgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCjbjDlfJBz\XO|aX;uJJZm[3SxcjDmc5IhemW2aX7vbYQhYCC{ZXPldJRweiCjbIDoZUB2e2mwZzD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE46|ryP MlHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|gwLz6FaFXNRmw9N2F-
CV-1 NUfsUZZiTnWwY4Tpc44h[XO|YYm= MWnDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCodX7jeIlwdmGuIHHjeIl3cXS7IHnuJGNXNTFiY3XscJMhfHKjboPm[YN1\WRid3n0bEBidiCneIDy[ZN{cW:wII\lZ5RweiCob4KgdoV1cW6xaXSgXEBz\WOncITvdkBo[W2vYTD1d4lv\yC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MT6x{txO NYTnR5pWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzhxJ{7DbGVOSkx:L3G+
CV-1 NULnRYhpTnWwY4Tpc44h[XO|YYm= M2n5dGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IH\1coN1cW:wYXygZYN1cX[rdImgbY4hS1ZvMTDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKGGwIHX4dJJme3Orb36geoVkfG:{IH\vdkBz\XSrbn;p[EBZKHKnY3XweI9zKGKndHGgeZNqdmdidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUGuOO69VQ>? Ml3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|gwLz6FaFXNRmw9N2F-
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... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Water Insoluble
Ethanol '''6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

In vivo Formulation Calculator (Clear solution)

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% DMSO % % Tween 80 % ddH2O
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03999684 Completed Drug: Tretinoin Adenoid Cystic Carcinoma Dana-Farber Cancer Institute|The V Foundation|ACCRF August 5 2019 Phase 2
NCT03611595 Recruiting Drug: Cabozantinib|Drug: 13-cis-retinoic acid Solid Tumor Peter Zage|Exelixis|University of California San Diego August 28 2018 Phase 1
NCT03200847 Active not recruiting Drug: Pembrolizumab with All-Trans Retinoic Acid Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma University of Colorado Denver|Merck Sharp & Dohme Corp. October 31 2017 Phase 1|Phase 2
NCT03323801 Completed Drug: 13-cis retinoic acid Male Infertility Azoospermia University of Washington July 25 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID