Tretinoin (NSC 122758)

Catalog No.S1653 Synonyms: Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A

For research use only.

Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

Tretinoin (NSC 122758) Chemical Structure

CAS No. 302-79-4

Selleck's Tretinoin (NSC 122758) has been cited by 20 publications

Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human breast cancer cell SK-BR-3 NGWzZVdRem:uaX\ldoF1cW:wIHHzd4F6 NVj0dotRUW6qaXLpeIlwdiCxZjDFVk1v\WejdHn2[UBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHygV2suSlJvMzDwdo9tcW[ncnH0bY9vNCCLQ{WwQVAvODBzNzFOwG0> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjN5MkWyNEc,OTJ|N{K1NlA9N2F-
T-47D cells MV\Qdo9tcW[ncnH0bY9vKGG|c3H5 MlfqTY5pcWKrdHnvckBw\iCHUjDwc5NqfGm4ZTDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGxiVD20O2QheHKxbHnm[ZJifGmxbjygTWM2OD1yLkKg{txO NHXuOXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO3NlUzOCd-MUKzO|I2OjB:L3G+
F9 NH3Gc3NHfW6ldHnvckBie3OjeR?= M2\nbWFjcWyrdImgeI8h\Gm|cHzhZ4UhOyC3TTDy[ZRqdm:rZDDhcoQhYzOKXXHscE11emGwcz3y[ZRqdm:rYzDhZ4llKGmwIF[5JIVu[nK7b37hcEBk[XKlaX7vcYEh[2WubIOgeZNqdmdiRkmgVIxie22rbn;n[Y4hSWO2aY\heI9zKHKnbHXhd4lv\yCjc4PhfUwhTUR3ME2wMlAxODIQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzN6OEi1K|4zPzN6OEi1QE9iRg>?
F9 M17xUmZ2dmO2aX;uJIF{e2G7 NUfJUnJQSWKrbHn0fUB1dyCmaYPwcIFk\SCdM1jdZYxtNXS{YX7zMZJmfGmwb3njJIFkcWRiZoLvcUBHQSCnbXLyfY9v[WxiY3HyZ4lvd22jIHPlcIx{NCC5YYOgZZN{\XO|ZXSgbY4h[SCIOTDsZY1qdmmwIILlcIVie2ViYYPzZZktKEWGNUC9NE4xODF3zszN MkCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd|OEi4OUc,Ojd|OEi4OVww[T5?
ASK NFPMcVFHfW6ldHnvckBie3OjeR?= MmOwNUBpeg>? NE[1VZdKdmS3Y4Tpc44hd2ZibX;ydIhwdG:paXPhcEB1emGwc3\vdo1ifGmxbjDv[kBz[XRiQWPLJINmdGy|IHnueI8h[XO2cn;jfZRmeyCjZoTldkAyKGi{IHL5JIxq\2i2IH3pZ5Jwe2OxcImsJGVFPTB;MUFOwG0> MnK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OU[0NUc,Ojh2OU[0NVww[T5?
CV-1 M{\ue2Z2dmO2aX;uJIF{e2G7 Ml7uWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLleIlvd2mlIHHjbYQhemWlZYD0c5IhWkGUIHfhcY1iNCCHQ{WwQVAvODByN988US=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PDlyN{K1K|44PDlyN{K1QE9iRg>?
CV-1 Ml7jSpVv[3Srb36gZZN{[Xl? NULuPXlOXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJmfGmwb3njJIFkcWRicnXj[ZB1d3JiUlHSJIJmfGFuIFXDOVA:OC5yMEJOwG0> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PDlyN{K1K|44PDlyN{K1QE9iRg>?
CV-1 MWrGeY5kfGmxbjDhd5NigQ>? M335[XRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDhcJBp[SxiRVO1NF0xNjByN988US=> NFKyNGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NEmwO|I2Lz55NEmwO|I2RC:jPh?=
HL-60 cdm-1 MX3GeY5kfGmxbjDhd5NigQ>? M3jySXRz[W6|Z3z1eIFucW6jc3WgZYN1cX[rdImgbY4hUExvNkCgZ4RuNTFiY3XscJMtKEWFNUC9NE4xODYQvF2= M2rZRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd4M{[4OFMoRjd4M{[4OFM9N2F-
mouse embryo limb bud cells M3jjcWZ2dmO2aX;uJIF{e2G7 MmHCTY4hfmm2cn:gbY5pcWKrdHnvckBw\iClaH;u[JJw\2WwZYPpd{BqdiCvb4Xz[UBmdWK{eX:gcIlu[iCkdXSgZ4VtdHNuIFnDOVA:OC5yM{JOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PjN4OESzK|44PjN4OESzQE9iRg>?
leukemia cells NHfsT|VHfW6ldHnvckBie3OjeR?= MlHrWIhmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEB1cGViYnnu[Ilv\yCxZjDbN2heSVSUQTD0c{Bz\XSrbn;pZ{Bi[2mmIILlZ4VxfG:{IHnuJIh2dWGwIIDyc416\WyxY4n0bYMhdGW3a3XtbYEh[2WubIOsJGlEPTB;MD6wNFA3O87:TR?= MlHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzZ|Nki3PUc,PzZ|Nki3PVww[T5?
CV-1 MmPySpVv[3Srb36gZZN{[Xl? MWLCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RicnX0bY5wcWNiQXPp[EBo[W2vYTDy[YNmeHSxcoOgZ48ufHKjboPm[YN1\WRiaX70c{BEXi1zIHPlcIx{NCCHQ{WwQVAvODIQvF2= MlPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDNyOEi2O{c,QDNyOEi2O|ww[T5?
CV-1 MXTGeY5kfGmxbjDhd5NigQ>? MlPKRolv\GmwZzDh[oZqdmm2eTDh[4FqdnO2IILleIlvd2mlIFHjbYQh[mW2YTDy[YNmeHSxcoOgZ48ufHKjboPm[YN1\WRiaX70c{BEXi1zIHPlcIx{NCCHQ{WwQVAvODkQvF2= NFvqe5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96M{C4PFY4Lz56M{C4PFY4RC:jPh?=
CV-1 MXPGeY5kfGmxbjDhd5NigQ>? NXvwfmFXSmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JJJmfGmwb3njJGFkcWRiYXzwbIEhemWlZYD0c5J{KGOxLYTyZY5{\mWldHXkJIlvfG9iQ2[tNUBk\WyuczygSWM2OD1yLkO1{txO NW\4WVBmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEOwPFg3Pyd-OEOwPFg3PzxxYU6=
CV-1 MkHKSpVv[3Srb36gZZN{[Xl? MoPvRolv\GmwZzDh[oZqdmm2eTDh[4FqdnO2IILleIlvd2mlIFHjbYQhYCCjbIDoZUBz\WOncITvdpMh[29vdILhcpNn\WO2ZXSgbY51dyCFVj2xJINmdGy|LDDFR|UxRTBwOd88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85OzB6OE[3K|45OzB6OE[3QE9iRg>?
CV-1 MmWxSpVv[3Srb36gZZN{[Xl? MWXCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RicnX0bY5wcWNiQXPp[EBZKGejbX3hJJJm[2WydH;yd{Bkdy22cnHud4Zm[3SnZDDpcpRwKEOYLUGgZ4VtdHNuIFXDOVA:OS5zzszN NVzXZ5RJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEOwPFg3Pyd-OEOwPFg3PzxxYU6=
CV-1 MkHkSpVv[3Srb36gZZN{[Xl? NF21UolDcW6maX7nJIFn\mmwaYT5JIFo[Wmwc4SgdoV1cW6xaXOgRYNq\CC[IHLleIEhemWlZYD0c5J{KGOxLYTyZY5{\mWldHXkJIlvfG9iQ2[tNUBk\WyuczygSWM2OD1zLkVOwG0> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85OzB6OE[3K|45OzB6OE[3QE9iRg>?
F9 NVfUbGJITnWwY4Tpc44h[XO|YYm= MVfJckB3cXS{bzDwdo9ud3Srb36gc4YheGyjc33pco9o\W5iYXP0bZZifG:{IIPlZ5JmfGmxbjDmdo9uKEZ7IDjteZJqdmVidHXyZZRw[2G{Y3nuc41iMSClZXzsd{whSUN3ME2wMlLPxE1? NFHseFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NUS0NVc2Lz56NUS0NVc2RC:jPh?=
CV-1 MneySpVv[3Srb36gZZN{[Xl? MknsWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLleIlvd2mlIHHjbYQhemWlZYD0c5IhWkGUIHfhcY1iNCCHQ{WwQVAvODN|zszN NITFOnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96N{C5NFk1Lz56N{C5NFk1RC:jPh?=
CV-1 NH63b5hHfW6ldHnvckBie3OjeR?= M3TLWXRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDi[ZRiNCCHQ{WwQVAvOTB3zszN NU\GT4F5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEewPVA6PCd-OEewPVA6PDxxYU6=
CV-1 NFrVfYFHfW6ldHnvckBie3OjeR?= M2f0[3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDhcJBp[SxiRVO1NF0xNjV4M988US=> M1frelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5MEmwPVQoRjh5MEmwPVQ9N2F-
CV-1 M{Th[mZ2dmO2aX;uJIF{e2G7 NYf3fYdbXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJmfGmwb3nkJHghemWlZYD0c5IhWliUIHHsdIhiNCCHQ{WwQVEvODh2zszN Ml:2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDdyOUC5OEc,QDdyOUC5OFww[T5?
CV-1 MWDGeY5kfGmxbjDhd5NigQ>? MYDUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUnX0bY5wcWRiWDDy[YNmeHSxcjDSXHIh\2GvbXGsJGVEPTB;MT6yNlXPxE1? NV3aUG5MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEewPVA6PCd-OEewPVA6PDxxYU6=
CV-1 NVnWVnlMTnWwY4Tpc44h[XO|YYm= M4nRWHRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rZDDYJJJm[2WydH;yJHJZWiCkZYThMEBGSzVyPUGuN|k1|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PzB7MEm0K|45PzB7MEm0QE9iRg>?
HL-60 MWLGeY5kfGmxbjDhd5NigQ>? NHnNWGJKdmS3Y4Tpc44hd2ZidILhcpNodHW2YX3pcoF{\SBqVFfhd4UqKGGldHn2bZR6KGmwIFjMMVYxKGOnbHzzMEBGSzVyPUCuNFA2|ryP MoK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDd6NES1OEc,QDd6NES1OFww[T5?
embryonic limb bud cells NVHVdooxTnWwY4Tpc44h[XO|YYm= MlnuTY5pcWKrdHnvckBw\iCFaH;u[JJw\2WwZYPpd{BqdiCmYYmgNVEh\W2kconvcolkKGyrbXKgZpVlKGOnbHzzMEBKSzVyPUCuNFMy|ryP M2XqNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5OES0OVQoRjh5OES0OVQ9N2F-
CV-1 NH\1TJdHfW6ldHnvckBie3OjeR?= NIDwT45VemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMt88US=> NWTCRm5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEm3PFg{Oid-OEm3PFg{OjxxYU6=
CV-1 NXnjb4ZVTnWwY4Tpc44h[XO|YYm= MYnUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUnX0bY5wcWNiYXPp[EBz\WOncITvdkBTSVJiYnX0ZUwhTUN3ME2wMlA5P87:TR?= MnnSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDl5OEizNkc,QDl5OEizNlww[T5?
CV-1 M4TYNGZ2dmO2aX;uJIF{e2G7 M1PN[nRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDhcJBp[SxiRVO1NF0xNjR3Od88US=> NX;O[mZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEm3PFg{Oid-OEm3PFg{OjxxYU6=
CV-1 MkHhSpVv[3Srb36gZZN{[Xl? NXjvV2gxXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJJJmfGmwb3nkJGEhemWlZYD0c5IhWkGUIHLleIEtKEWFNUC9NE4xODMQvF2= M3PXdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl3N{K4PVMoRjl3N{K4PVM9N2F-
CV-1 MnjvSpVv[3Srb36gZZN{[Xl? MYTUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdicnX0bY5wcWRiWDDy[YNmeHSxcjDSXHIh\2GvbXGsJGVEPTB;MD6wNFbPxE1? NVLjWXB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW3Nlg6Oyd-OUW3Nlg6OzxxYU6=
CV-1 MoXOSpVv[3Srb36gZZN{[Xl? M3G2N3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDy[ZRqdm:rZDDBJJJm[2WydH;yJHJCWiCjbIDoZUwhTUN3ME2wMlAzOs7:TR?= NUjr[4dYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUW3Nlg6Oyd-OUW3Nlg6OzxxYU6=
HL-60 NVT0e4E4TnWwY4Tpc44h[XO|YYm= M2T1UGlv\HWldHnvckBw\iCKTD22NEBk\WyuczDkbYZn\XKnboTpZZRqd25ib4\ldkA1KGSjeYOsJGVFPTB;MD6xNu69VQ>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PTd{OEmzK|46PTd{OEmzQE9iRg>?
HL-60 M17UN2N6fG:|dHH0bYMh[XO|YYm= NEDDOGhEgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhUExvNkCgZ4VtdHNuIFnDOVA:OTIQvF2= M4XEW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNUi1NlA3Lz5zMEW4OVIxPjxxYU6=
CV-1 MmTMSpVv[3Srb36gZZN{[Xl? NVizboR3XHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCpYX3tZUBz\WOncITvdkwhTUN|ME2wMlAxODJ{zszN MoG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5NkKwN|goRjFyN{[yNFM5RC:jPh?=
CV-1 Ml\BSpVv[3Srb36gZZN{[Xl? M{\EZ3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDSRXIh[mW2YTDy[YNmeHSxcjygSWM{OD1yLkCwNFk{|ryP M1vJ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{[yNFM5Lz5zMEe2NlA{QDxxYU6=
CV-1 MVPGeY5kfGmxbjDhd5NigQ>? M{OxbnRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDSRXIh[WyyaHGgdoVk\XC2b4KsJGVEOzB;MD6wNFA6Qc7:TR?= NXqxW3pGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC3OlIxOzhpPkGwO|YzODN6PD;hQi=>
CV-1 M{DodWZ2dmO2aX;uJIF{e2G7 MkTkVoVt[XSrdnWgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLBVkBidHCqYTDy[YNmeHSxcjDjc41x[XKnZDD0c{BCXFKDLDDS[YxifGm4ZTDFR|MxRTBwMECx{txO MkDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5NkKwN|goRjFyN{[yNFM5RC:jPh?=
CV-1 M{fqbGZ2dmO2aX;uJIF{e2G7 MYjS[YxifGm4ZTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiUlHSJIJmfGFicnXj[ZB1d3JiY3;tdIFz\WRidH:gRXRTSSxiUnXsZZRqfmViRVOzNF0xNjByMd88US=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODd4MkCzPEc,OTB5NkKwN|g9N2F-
CV-1 NXXETHRtTnWwY4Tpc44h[XO|YYm= Mln0VoVt[XSrdnWgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLBVkBo[W2vYTDy[YNmeHSxcjDjc41x[XKnZDD0c{BCXFKDLDDS[YxifGm4ZTDFR|MxRTBwMECx{txO NUXVRoVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC3OlIxOzhpPkGwO|YzODN6PD;hQi=>
CV-1 NIniU|RHfW6ldHnvckBie3OjeR?= MofjWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS1ZvMTDj[YxteyCneIDy[ZN{cW6pIGLBVkBo[W2vYTDy[YNmeHSxcjygSWM{OD1yLkCwNFE5|ryP MmnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5NkKwN|koRjFyN{[yNFM6RC:jPh?=
CV-1 MmX1SpVv[3Srb36gZZN{[Xl? NVPKS3RuXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCkZYThJJJm[2WydH;yMEBGSzNyPUCuNFAxPjoQvF2= Mkm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5NkKwN|koRjFyN{[yNFM6RC:jPh?=
CV-1 MoD6SpVv[3Srb36gZZN{[Xl? NWG1bIdoXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJCWiCjbIDoZUBz\WOncITvdkwhTUN|ME2wMlAxOTIQvF2= M4LUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{[yNFM6Lz5zMEe2NlA{QTxxYU6=
COS NI\5PHNHfW6ldHnvckBie3OjeR?= M3qzXXRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEORUzDj[YxteyCneIDy[ZN{cW6pIGLBVk1o[W2vYTygVoVt[XSrdnWgSWM{OD1yLkCwNFI3|ryP MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODl3NkKwNUc,OTB7NU[yNFE9N2F-
COS MXfGeY5kfGmxbjDhd5NigQ>? NUL2WZBNXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ1;TJINmdGy|IHX4dJJme3OrbnegVmFTNWKndHGsJHJmdGG2aY\lJGVEOzB;MD6wNFIz|ryP NXjaRVduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC5OVYzODFpPkGwPVU3OjBzPD;hQi=>
COS M1nIdWZ2dmO2aX;uJIF{e2G7 NUXNNYVEXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ1;TJINmdGy|IHX4dJJme3OrbnegVmFTNWGucHjhMEBT\WyjdHn2[UBGSzNyPUCuNFA{PM7:TR?= NGnWNHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm1OlIxOSd-MUC5OVYzODF:L3G+
HL60 M{nySGZ2dmO2aX;uJIF{e2G7 MlvDTY4hfmm2cn:gZ5l1d3SxeHnjbZR6KGGpYXnud5QhUEx4MDDj[YxteyxiSVO1NF0yOc7:TR?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTF{OE[0PEc,OTFzMki2OFg9N2F-
CV-1 NH;pfVNHfW6ldHnvckBie3OjeR?= MVnUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiaIXtZY4hWmW2aX7vbYMh[WOrZDDy[YNmeHSxcjDSRXIh\2GvbXGsJGVEPTB;MD6wNVnPxE1? NH[1VVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS4NlQ{PSd-MUK0PFI1OzV:L3G+
CV-1 MV3GeY5kfGmxbjDhd5NigQ>? NYnIVo42XHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJIh2dWGwIGLleIlvd2mlIHHjbYQhemWlZYD0c5IhWkGUIHLleIEtKEWFNUC9NE4xPzkQvF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR6MkSzOUc,OTJ2OEK0N|U9N2F-
CV-1 MW\GeY5kfGmxbjDhd5NigQ>? MUDUdoFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDpckBEXi1zIHPlcIx{KGW6cILld5NqdmdiaIXtZY4hWmW2aX7vbYMh[WOrZDDy[YNmeHSxcjDSRXIh[WyyaHGsJGVEPTB;MD60N|bPxE1? NGPJS4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS4NlQ{PSd-MUK0PFI1OzV:L3G+
CV-1 MUDGeY5kfGmxbjDhd5NigQ>? NF3abWFVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegcY92e2ViUnX0bY5wcWRiWDDy[YNmeHSxcjDSXHIh\2GvbXGsJGVEPTB;MD65OlHPxE1? Mnu0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2OEK0N|UoRjF{NEiyOFM2RC:jPh?=
CV-1 M3LQc2Z2dmO2aX;uJIF{e2G7 M1Po[nRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDoeY1idiCUZYTpco9q\CC[IILlZ4VxfG:{IGLYVk1idHCqYTygSWM2OD1zLkCxOe69VQ>? MnXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2OEK0N|UoRjF{NEiyOFM2RC:jPh?=
CV-1 NHXoRnZHfW6ldHnvckBie3OjeR?= NGrZbXNVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegcY92e2ViUnX0bY5wcWRiWDDy[YNmeHSxcjDSXHIh[mW2YTygSWM2OD1zLkKxNe69VQ>? MlqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2OEK0N|UoRjF{NEiyOFM2RC:jPh?=
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MCF7 NHu2NItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M330[FYh\GG7cx?= NWTKO4lPT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTkQvF2= MlTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1NlEoRjF3NkG1OVIyRC:jPh?=
MCF7 MkX4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MU\BcpRqeHKxbHnm[ZJifGm4ZTDl[oZm[3RiYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{NCCLQ{WwQVAvPTh2Nd88US=> MlT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MUW1NlEoRjF3NkG1OVIyRC:jPh?=
PC3 NVjZeldnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1vGSVYh\GG7cx?= NEXCOoZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2y{txO NF3ETI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNU[xOVUzOSd-MUW2NVU2OjF:L3G+
LNCaP Ml25S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2DCZVYh\GG7cx?= NYLLfoRwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVE6FYWCgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOM7:TR?= NXrJUZd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2NVU2OjFpPkG1OlE2PTJzPD;hQi=>
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Raji NGLXNVZHfW6ldHnvckBie3OjeR?= MYe0PEBpenN? NX7BVZNuUW6qaXLpeIlwdiCxZjDUVGEucW6mdXPl[EBGeHO2ZXnuMWJienJidnnyeZMh\WG{bImgZY51cWenbjDhZ5RqfmG2aX;uJIlvKFKjanmgZ4VtdHNiYX\0[ZIhPDhiaILzMEBKSzVyPUCuNFE2PM7:TR?= NFP5S4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WwN|g2OCd-MUe1NFM5PTB:L3G+
HaCaT NH72fI1HfW6ldHnvckBie3OjeR?= MV;JcoNz\WG|ZTDpckB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgc4YhWkGUYXzwbIEhemWlZYD0c5Ih\XC{ZYPz[YQhcW5iaIXtZY4hUGGFYWSgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDEVlUufGtvQ1HUJJJmeG:{dHXyJJBt[XOvaXSgZZN{\XO|ZXSgZZMh[mW2YT3nZYxi[3Sxc3nkZZNmKGGldHn2bZR6KGK7IFPBWE1GVEmVQR?= NXvsWo9SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NVEzQDNpPkG4OVEyOjh|PD;hQi=>
PC3 NHL4NHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIW0cZE2KGSjeYO= M3TvbWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{Bi\nSncjC1JIRigXNiYomgUXRVKGG|c3H5MEBIUTVyPUeuOu69VQ>? NGD3VFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW0N|kxOid-MUi1OFM6ODJ:L3G+
MDA-MB-231 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX[1JIRigXN? NEDWdWtIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO|YYmsJGdKPTB;MUCuPFXPxE1? M{jaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUSzPVAzLz5zOEW0N|kxOjxxYU6=
COS7 MoDqSpVv[3Srb36gZZN{[Xl? MXWxOkBpenN? NFrmN4FC[3Srdnn0fUBifCCqdX3hckBTSVKpYX3tZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCjc4Pld5Nm\CCjczD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDh[pRmeiBzNjDodpMh[nliR3HsOEBz\XOyb37z[UBmdGWvZX70MYRzcX[nbjDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xODB{zszN MlnUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUi5OlUoRjF7MEW4PVY2RC:jPh?=
COS7 NHfqXm1HfW6ldHnvckBie3OjeR?= MlHuNVYhcHK| NISyenJC[3Srdnn0fUBifCCqdX3hckBTSVKkZYThJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStSGJFKGG|c3Xzd4VlKGG|IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHmeIVzKDF4IHjyd{BjgSCJYXy0JJJme3CxboPlJIVt\W2nboSt[JJqfmWwIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAyOs7:TR?= NI\zelM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1PFk3PSd-MUmwOVg6PjV:L3G+
COS7 MUPGeY5kfGmxbjDhd5NigQ>? MVGxOkBpenN? NFX4OXlC[3Srdnn0fUBifCCqdX3hckBTSVKjbIDoZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCjc4Pld5Nm\CCjczD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDh[pRmeiBzNjDodpMh[nliR3HsOEBz\XOyb37z[UBmdGWvZX70MYRzcX[nbjDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xOTgQvF2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3OEm2OUc,OTlyNUi5OlU9N2F-
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NIH3T3 NF;v[VlHfW6ldHnvckBie3OjeR?= MUjBZ5Rqfmm2eTDheEBTSVKjbIDoZUBmgHC{ZYPz[YQhcW5ibX;1d4UhVkmKM2SzJINmdGy|IHL5JHIuW0GWIHHzd4F6NCCHQ{WwQVAvODB4M{JOwG0> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUKzNEc,OTl{M{myN|A9N2F-
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CV-1 MXzGeY5kfGmxbjDhd5NigQ>? MUjDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCodX7jeIlwdmGuIHHjeIl3cXS7IHnuJGNXNTFiY3XscJMhfHKjboPm[YN1\WRid3n0bEBidiCneIDy[ZN{cW:wII\lZ5RweiCob4KgdoV1cW6xaXOgZYNq\CC{ZXPldJRweiCpYX3tZUB2e2mwZzD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xODB5zszN NGjXRY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{QC9pPlPoSW1DVDxxYU6=
CV-1 NX7jNYg3TnWwY4Tpc44h[XO|YYm= MmrYR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiZoXuZ5Rqd26jbDDhZ5Rqfmm2eTDpckBEXi1zIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgh[W5iZYjwdoV{e2mxbjD2[YN1d3JiZn;yJJJmfGmwb3njJIFkcWRicnXj[ZB1d3JiYnX0ZUB2e2mwZzD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xODIQvF2= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzPE8oRkOqRV3CUFww[T5?
CV-1 NXnNVYdFTnWwY4Tpc44h[XO|YYm= NFPyVWREd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDmeY5kfGmxbnHsJIFkfGm4aYT5JIlvKEOYLUGgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCjbjDlfJBz\XO|aX;uJJZm[3SxcjDmc5IhemW2aX7vbYMh[WOrZDDy[YNmeHSxcjDhcJBp[SC3c3nu[{B1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5yMEhOwG0> NXnjN5gyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzhxJ{7DbGVOSkx:L3G+
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CV-1 NXXoS29lTnWwY4Tpc44h[XO|YYm= NUPXUIRSS2:vcH;1coQhf2G|IITld5Rm\CCob4Kg[pVv[3Srb37hcEBi[3Srdnn0fUBqdiCFVj2xJINmdGy|IITyZY5{\mWldHXkJJdqfGhiYX6g[ZhxemW|c3nvckB3\WO2b4Kg[o9zKHKndHnuc4llKFhicnXj[ZB1d3JiYXzwbIEhfXOrbnegeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvQc7:TR?= M2DLPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFM5Nyd-Q3jFUWJNRC:jPh?=
CV-1 NFHWSlRHfW6ldHnvckBie3OjeR?= MVzDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCodX7jeIlwdmGuIHHjeIl3cXS7IHnuJGNXNTFiY3XscJMhfHKjboPm[YN1\WRid3n0bEBidiCneIDy[ZN{cW:wII\lZ5RweiCob4KgdoV1cW6xaXSgXEBz\WOncITvdkBo[W2vYTD1d4lv\yC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MT6x{txO MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzPE8oRkOqRV3CUFww[T5?
CV-1 NIfFWo5HfW6ldHnvckBie3OjeR?= NGXiNFVEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDmeY5kfGmxbnHsJIFkfGm4aYT5JIlvKEOYLUGgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCjbjDlfJBz\XO|aX;uJJZm[3SxcjDmc5IhemW2aX7vbYQhYCC{ZXPldJRweiCkZYThJJV{cW6pIITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2xMlTPxE1? M33BfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFM5Nyd-Q3jFUWJNRC:jPh?=
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In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05316675 Not yet recruiting Drug: Isotretinoin Acne Vulgaris Assiut University December 2022 Phase 4
NCT04149418 Active not recruiting Other: Yogurt|Other: Control food Obesity|Inflammation University of Wisconsin Madison|National Dairy Council|University of Massachusetts Amherst October 15 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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