Tretinoin

For research use only.

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

6 publications

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Tretinoin has been cited by 6 publications

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  • HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.

    Cell, 2018, 175(5):1244-1258. Tretinoin purchased from Selleck.

Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells MVLGeY5kfGmxbjDhd5NigQ>? NY\BO|ZlOyCmYYnz NVTrboMyUW6mdXP0bY9vKG:oIITldo1qdmGuIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCIOTDj[YxteyCjc4Pld5Nm\CCkeTDt[YF{fXKrbnegd4VkemW2ZXSgdIxie22rbn;n[Y4h[WO2aY\heI9zKGGldHn2bZR6KGGodHXyJFMh\GG7czygTWM2OD1yLkCwNFEh|ryP Mn\QNVc1QDl3N{m=
COS7 cells NVTpc5QzTnWwY4Tpc44h[XO|YYm= MVuxOkBp NV;BbolKSWO2aY\peJkh[XRiaIXtZY4hWkGUZ3HtcYEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1FSkRiYYPz[ZN{\WRiYYOgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZYZ1\XJiMU[gbJJ{KGK7IFfhcFQhemW|cH;ud4Uh\WynbXXueE1lemm4ZX6gcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODByMjFOwG0> MUOxPVA2QDl4NR?=
CV-1 cells MXrGeY5kfGmxbjDhd5NigQ>? NITIPGhVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMEC3JO69VQ>? NVfNR21rPzR7MEeyOS=>
human breast cancer cell SK-BR-3 MYfQdo9tcW[ncnH0bY9vKGG|c3H5 M{[zPWlvcGmkaYTpc44hd2ZiRWKtcoVo[XSrdnWgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuIGPLMWJTNTNicILvcIln\XKjdHnvckwhUUN3ME2wMlAxOTdizszN NX7lfHhEOTJ|N{K1NlA>
HL-60 cells M3HPXWZ2dmO2aX;uJIF{e2G7 NGLYVFFKdmS3Y4Tpc44hd2ZidILhcpNodHW2YX3pcoF{\SBqVFfhd4UqKGGldHn2bZR6KGmwIFjMMVYxKGOnbHzzMEBGSzVyPUCuNFA2KM7:TR?= NEnBbGw5Pzh2NEW0
human T47D cells NEPJdZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPnOkBl[Xm| NIrXc2pIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE4xODZizszN NWjBcJBVOTV4MUW1NlE>
mouse NIH3T3 cells MoLHSpVv[3Srb36gZZN{[Xl? MlzCRYN1cX[rdImgZZQhWkGUYXzwbIEh\XiycnXzd4VlKGmwIH3veZNmKE6LSEPUN{Bk\WyuczDifUBTNVODVDDhd5NigSxiRVO1NF0xNjByNkOxJO69VQ>? NGTzS3kyQTJ|OUKzNC=>
Raji cells NXvtOZFJTnWwY4Tpc44h[XO|YYm= MmCwOFghcA>? NUO2b5BjUW6qaXLpeIlwdiCxZjDUVGEucW6mdXPl[EBGeHO2ZXnuMWJienJidnnyeZMh\WG{bImgZY51cWenbjDhZ5RqfmG2aX;uJIlvKFKjanmgZ4VtdHNiYX\0[ZIhPDhiaILzMEBKSzVyPUCuNFE2PCEQvF2= Ml3CNVc2ODN6NUC=
human MV-4-11 cell M{TVZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{e0[GlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODJyOUmg{txO M1frc3NCVkeHUh?=
human ATN-1 cell NV\qVYQ4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7wPIZwUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODNyMzFOwG0> NIfzXo1USU6JRWK=
HL-60 cells MlvqSpVv[3Srb36gZZN{[Xl? MYi0JIRigXN? MULJcoR2[3Srb36gc4YhUExvNkCgZ4VtdHNiZHnm[oVz\W62aXH0bY9vKG:4ZYKgOEBl[Xm|LDDFSFUxRTBwMUKg{txO NEGyWWk6PTd{OEmz
human MC-IXC cell MmHwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUT5fI11UW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3NEO2JO69VQ>? MlzRV2FPT0WU
human HH cell NGXSNWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGDWS4NKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPVU2PCEQvF2= M2T2fXNCVkeHUh?=
T-47D cells MYTQdo9tcW[ncnH0bY9vKGG|c3H5 MkC0TY5pcWKrdHnvckBw\iCHUjDwc5NqfGm4ZTDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGxiVD20O2QheHKxbHnm[ZJifGmxbjygTWM2OD1yLkKg{txO M4ThWFEzOzd{NUKw
human NB13 cell M3:0Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1TXcWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlU3PjRizszN NESwTpRUSU6JRWK=
human D-283MED cell MnzuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGLjZohKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{OEK2NkDPxE1? MYnTRW5ITVJ?
human HL-60 cell M1njOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEC3VmpKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zQDR7MTFOwG0> NHHIc4JUSU6JRWK=
human EW-3 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjlTY5pcWKrdHnvckBw\iCqdX3hckBGXy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD60PFAzQCEQvF2= NUTkbIpEW0GQR1XS
human LNCAP cells NFO5[5JRem:uaX\ldoF1cW:wIHHzd4F6 NFmwbG81QCCq NIPEeHdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD61JO69VQ>? NEPGZXMyQTN5NUiyOS=>
human KU812 cell M2jpOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\IO2lvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlU{PjB7IN88US=> MmPxV2FPT0WU
human MCF7 cells M4i2S2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXHDV4ZGPiCmYYnz NHnwZlVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE42QCEQvF2= MlvvNVU3OTV3MkG=
NB4 cell M{X6UGZ2dmO2aX;uJIF{e2G7 MYTJcoR2[3Srb36gc4YhVkJ2IHPlcIwh\GmoZnXy[Y51cWG2aX;uMEBGTDVyPUCuOlEh|ryP M3HBO|k2PzJ6OUO=
human SK-NEP-1 cell M4X1cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjMTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjZ{M{Gg{txO M2rFXHNCVkeHUh?=
human HCC1806 cell NELFWVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2i4cmlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUiwOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ7Mkmg{txO M{jidnNCVkeHUh?=
human T47D cells NVq2bmZCS3m2b4TvfIlkyqCjc4PhfS=> MUW0PEBp NWD6c2dzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OD1yLkiyJO69VQ>? Ml30NlU4ODF{NUG=
human HuO-3N1 cell MmO2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3rafWlvcGmkaYTpc44hd2ZiaIXtZY4hUHWRLUPONUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQDNzNjFOwG0> MYTTRW5ITVJ?
human RPMI-8226 cell MnH2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1fkcGlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24NlI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OUOzOEDPxE1? NYLOW5plW0GQR1XS
human LAMA-84 cell NWL1UG9FT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnu5TY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QTZ|NTFOwG0> M1r1XXNCVkeHUh?=
human NCI-H720 cell M3LReGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jPfWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB{NkKxJO69VQ>? MmLBV2FPT0WU
human MOLT-13 cell NVvvXWl4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2\acWlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTR3IN88US=> MVfTRW5ITVJ?
human JVM-2 cell NIDyNJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xO|MyPiEQvF2= M4\VXnNCVkeHUh?=
human NBsusSR cell Mlq5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzXTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDl6NzFOwG0> NXnqUY5JW0GQR1XS
human BV-173 cell NVzoWoNCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH7WO5ZKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTl4Mk[g{txO Mne3V2FPT0WU
human CTB-1 cell NIjTT2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV6zRmtXUW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB|OEmg{txO NIXOcmlUSU6JRWK=
human ACN cell MnT3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIf0clZKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlQ6QTlizszN NF:xSnJUSU6JRWK=
human PC3 cells MojkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnvsOkBl[Xm| NXq1cGM2T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NkDPxE1? NXS1bnduOTV4MUW1NlE>
human L-363 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTpTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFY6PjRizszN NX3hNGxDW0GQR1XS
human NCI-H69 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPJZWtKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ4NU[xJO69VQ>? NFHGdpBUSU6JRWK=
human ECC10 cell NHXuV|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEP6OW1KdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QDB3MjFOwG0> Mn;aV2FPT0WU
human NCI-H209 cell NYj2cmExT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XhRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV{MUOyJO69VQ>? NGXzdYtUSU6JRWK=
human KARPAS-45 cell M37hW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnnFTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV7NUixJO69VQ>? MWHTRW5ITVJ?
human COR-L88 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wN{45PTh5MjFOwG0> MVHTRW5ITVJ?
human ML-2 cell Mk\vS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFPUbZNKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlAxPDN7IN88US=> NYTmUnA6W0GQR1XS
human U-266 cell NIfQ[plIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXLkNXU4UW6qaXLpeIlwdiCxZjDoeY1idiCXLUK2OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTF6Mkmg{txO M3;ST3NCVkeHUh?=
human HT-29 cells MXvDfZRwfG:6aXRCpIF{e2G7 MnzVOFghcA>? MlvLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlMh|ryP M2C4PVIxPDB3OES5
human RS4-11 cell M1nOW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFQ4OzdizszN NUjmOmhRW0GQR1XS
human DB cell Mkf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTTWJFVUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuO|Y2OTlizszN MoTmV2FPT0WU
human NB14 cell Mm\lS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUm0T492UW6qaXLpeIlwdiCxZjDoeY1idiCQQkG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4yOjdzIN88US=> M4jue3NCVkeHUh?=
human BPH-1 cell NVLCbFJXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWS3fmI3UW6qaXLpeIlwdiCxZjDoeY1idiCEUFitNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPDN4MUGg{txO NYLTVZRzW0GQR1XS
human PC3 cells MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHocmNbPSCmYYnz NESzb2JIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhT0l3ME23MlYh|ryP M1LNfFE5PTR|OUCy
human EW-13 cell NHrnb|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml;ETY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOlExPzhizszN NFH0U3ZUSU6JRWK=
human NCI-H526 cell MlHYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43QDJ7MTFOwG0> MXPTRW5ITVJ?
human NKM-1 cell NXnj[ZZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXjVS3FoUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDFyMEmg{txO NVfxV5BPW0GQR1XS
human MDA-MB-453 cells MV;DfZRwfG:6aXRCpIF{e2G7 Mmr6OFghcA>? NUjnU|dUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ2OyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF06NjVzIN88US=> NVjoUnJkOjV5MEGyOVE>
human MEG-01 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{\GN2lvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OTNzODFOwG0> MnPWV2FPT0WU
human NCI-H1648 cell NEfQW5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX35Vmp3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkezOlE4KM7:TR?= MoPkV2FPT0WU
human LNCaP cells Mle4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXi2JIRigXN? NWOxVpBYT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVE6FYWCgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOCEQvF2= NWfQU5B4OTV4MUW1NlE>
human GP5d cell NULJfohDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2Puc2lvcGmkaYTpc44hd2ZiaIXtZY4hT1B3ZDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlI3OzdizszN M4PU[3NCVkeHUh?=
human MDA-MB-231 cells NIrObGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\2T|Uh\GG7cx?= NVv4VlZKT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC1JIRigXNiYomgUXRVKGG|c3H5MEBIUTVyPUGwMlg2KM7:TR?= MYixPFU1OzlyMh?=
human DU145 cells MUTDfZRwfG:6aXRCpIF{e2G7 M2fIfVQ5KGh? MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0yOS54NDFOwG0> MWSyOVcxOTJ3MR?=
human DEL cell NEX6[VRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3rXSGlvcGmkaYTpc44hd2ZiaIXtZY4hTEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuN|czQCEQvF2= NWP0eXdNW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
in solvent
Synonyms All-trans Retinoic Acid
Smiles CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03999684 Recruiting Drug: Tretinoin Adenoid Cystic Carcinoma Dana-Farber Cancer Institute|The V Foundation|ACCRF August 5 2019 Phase 2
NCT03200847 Recruiting Drug: Pembrolizumab with All-Trans Retinoic Acid Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma University of Colorado Denver|Merck Sharp & Dohme Corp. October 31 2017 Phase 1|Phase 2
NCT02620813 Completed Drug: Tretinoin|Drug: Isotretinoin Acne Vulgaris University of California Davis October 2015 Phase 4
NCT01969058 Completed Drug: Isotretinoin HIV-1 Infection AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) July 2014 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID