Tretinoin

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Cited by 2 Publications

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  • HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.

    Cell, 2018, 175(5):1244-1258. Tretinoin purchased from Selleck.

Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells NFu3PYVHfW6ldHnvckBie3OjeR?= MmPyN{Bl[Xm| NYHLc5pjUW6mdXP0bY9vKG:oIITldo1qdmGuIHTp[oZmemWwdHnheIlwdiCrbjDtc5V{\SCIOTDj[YxteyCjc4Pld5Nm\CCkeTDt[YF{fXKrbnegd4VkemW2ZXSgdIxie22rbn;n[Y4h[WO2aY\heI9zKGGldHn2bZR6KGGodHXyJFMh\GG7czygTWM2OD1yLkCwNFEh|ryP MoXJNVc1QDl3N{m=
COS7 cells NXPme5AyTnWwY4Tpc44h[XO|YYm= M3[xSlE3KGh? MXTBZ5Rqfmm2eTDheEBpfW2jbjDSRXJo[W2vYTDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIFPPV|ch[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBI[Wx2LVTCSEBie3Onc4Pl[EBieyC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCjZoTldkAyPiCqcoOgZpkhT2GuNDDy[ZNxd26|ZTDlcIVu\W62LXTybZZmdiCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFAzKM7:TR?= MlzRNVkxPTh7NkW=
CV-1 cells MVzGeY5kfGmxbjDhd5NigQ>? NGHoc|lVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMEC3JO69VQ>? NV;3eI54PzR7MEeyOS=>
human breast cancer cell SK-BR-3 NH7SZXZRem:uaX\ldoF1cW:wIHHzd4F6 MnyxTY5pcWKrdHnvckBw\iCHUj3u[YdifGm4ZTDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGxiU1utRnIuOyCycn;sbYZmemG2aX;uMEBKSzVyPUCuNFAyPyEQvF2= NF3FSlUyOjN5MkWyNC=>
HL-60 cells NETGZ5VHfW6ldHnvckBie3OjeR?= MmLQTY5lfWO2aX;uJI9nKHS{YX7z[4x2fGGvaX7hd4UhMFSJYYPlLUBi[3Srdnn0fUBqdiCKTD22NEBk\WyuczygSWM2OD1yLkCwOUDPxE1? NHLicpM5Pzh2NEW0
human T47D cells MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{m2NFYh\GG7cx?= Mn;TS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gWFQ4TCClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFA3KM7:TR?= NFK1Ro8yPTZzNUWyNS=>
mouse NIH3T3 cells M4TaUmZ2dmO2aX;uJIF{e2G7 NITJOVhC[3Srdnn0fUBifCCUQWLhcJBp[SCneIDy[ZN{\WRiaX6gcY92e2ViTlnIN3Q{KGOnbHzzJIJ6KFJvU1HUJIF{e2G7LDDFR|UxRTBwMEC2N|Eh|ryP NGL1OYgyQTJ|OUKzNC=>
Raji cells MoPUSpVv[3Srb36gZZN{[Xl? NWjQfXdoPDhiaB?= NEDT[ZBKdmirYnn0bY9vKG:oIGTQRU1qdmS3Y3XkJGVxe3SnaX6tRoFzeiC4aYL1d{Bm[XKueTDhcpRq\2WwIHHjeIl3[XSrb36gbY4hWmGsaTDj[YxteyCjZoTldkA1QCCqcoOsJGlEPTB;MD6wNVU1KM7:TR?= MkXwNVc2ODN6NUC=
human MV-4-11 cell MnLCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIj4TmdKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{MEm5JO69VQ>? M2T1[3NCVkeHUh?=
human ATN-1 cell NULRXYRNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVrMdldxUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODNyMzFOwG0> MYfTRW5ITVJ?
HL-60 cells M3rCTWZ2dmO2aX;uJIF{e2G7 MWe0JIRigXN? M4jORmlv\HWldHnvckBw\iCKTD22NEBk\WyuczDkbYZn\XKnboTpZZRqd25ib4\ldkA1KGSjeYOsJGVFPTB;MD6xNkDPxE1? NYLkdlRWQTV5Mki5Ny=>
human MC-IXC cell NX61UWgxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3O4R2lvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPTR|NjFOwG0> M2C0NnNCVkeHUh?=
human HH cell NXTueXBrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTQeGpKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPVU2PCEQvF2= NVrzbpZ7W0GQR1XS
T-47D cells MWnQdo9tcW[ncnH0bY9vKGG|c3H5 MkXrTY5pcWKrdHnvckBw\iCHUjDwc5NqfGm4ZTDoeY1idiCkcnXhd5Qh[2GwY3XyJINmdGxiVD20O2QheHKxbHnm[ZJifGmxbjygTWM2OD1yLkKg{txO NWXjWmdOOTJ|N{K1NlA>
human NB13 cell NGfzb|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fEOWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlU3PjRizszN Ml\NV2FPT0WU
human D-283MED cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XoU2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ6Mk[yJO69VQ>? M3z5VXNCVkeHUh?=
human HL-60 cell M3TLbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnLzTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlg1QTFizszN MXrTRW5ITVJ?
human EW-3 cell NXLzV5hOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3:3[mlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOFgxOjhizszN NGrBOlNUSU6JRWK=
human LNCAP cells MXfQdo9tcW[ncnH0bY9vKGG|c3H5 NGXjR2Q1QCCq MlXZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNTFOwG0> M{XR[VE6Ozd3OEK1
human KU812 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPlcHFKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42OzZyOTFOwG0> MmrLV2FPT0WU
human MCF7 cells MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY\vNVl2PiCmYYnz M4qyT2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlU5KM7:TR?= MX2xOVYyPTV{MR?=
NB4 cell MYDGeY5kfGmxbjDhd5NigQ>? MnPOTY5lfWO2aX;uJI9nKE6ENDDj[YxtKGSrZn\ldoVvfGmjdHnvckwhTUR3ME2wMlYyKM7:TR?= MVi5OVczQDl|
human SK-NEP-1 cell NWLHcVBkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlnKTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjZ{M{Gg{txO MWfTRW5ITVJ?
human HCC1806 cell MorUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjnOVJCUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxPFA3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC55MkmyPUDPxE1? M3Xr[nNCVkeHUh?=
human T47D cells MXnDfZRwfG:6aXRCpIF{e2G7 MnXhOFghcA>? NWKw[o1lS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygS2k2OD1yLkiyJO69VQ>? NF;zPIczPTdyMUK1NS=>
human HuO-3N1 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUXYRoRrUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC56M{G2JO69VQ>? NUn5NVRDW0GQR1XS
human RPMI-8226 cell NHL1d21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\vdFlKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFIzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUmzN|Qh|ryP MmS0V2FPT0WU
human LAMA-84 cell NHXHXFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXHTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QTZ|NTFOwG0> NU\qbnA1W0GQR1XS
human NCI-H720 cell M4nSWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYj2dFRTUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFczOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEK2NlEh|ryP MkLDV2FPT0WU
human MOLT-13 cell M{HnPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1PSEQvF2= M1rjenNCVkeHUh?=
human JVM-2 cell MmDYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLsT|FoUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTd|MU[g{txO MknPV2FPT0WU
human NBsusSR cell MoWyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGT2b|NKdmirYnn0bY9vKG:oIHj1cYFvKE6Ec4XzV3Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR2OUi3JO69VQ>? Mn;KV2FPT0WU
human BV-173 cell NY\6NWN7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVk3OjZizszN NVzwVY1yW0GQR1XS
human CTB-1 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fWfGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxOzh7IN88US=> NXzLXlZ6W0GQR1XS
human ACN cell M1nrOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1T6bmlvcGmkaYTpc44hd2ZiaIXtZY4hSUOQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OFk6QSEQvF2= MVvTRW5ITVJ?
human PC3 cells NIPxRnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jqc|Yh\GG7cx?= Ml63S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MjFOwG0> MlPqNVU3OTV3MkG=
human L-363 cell MlqwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4TUdWlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA3QTZ2IN88US=> MWHTRW5ITVJ?
human NCI-H69 cell NHrEPJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXHNYdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ4NU[xJO69VQ>? NEL2b3lUSU6JRWK=
human ECC10 cell M33kW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKGi3bXHuJGVESzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFA2OiEQvF2= NXHlNGJpW0GQR1XS
human NCI-H209 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWn0VohSUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUKxN|Ih|ryP NGrZTFVUSU6JRWK=
human KARPAS-45 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYroTYUzUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW5OVgyKM7:TR?= M{ewU3NCVkeHUh?=
human COR-L88 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULFXmZwUW6qaXLpeIlwdiCxZjDoeY1idiCFT2KtUFg5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:ODNwOEW4O|Ih|ryP NVPOUXB[W0GQR1XS
human ML-2 cell M3jDfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVHUS2F7UW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4xODR|OTFOwG0> NHj1b2RUSU6JRWK=
human U-266 cell M{[zZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jKdGlvcGmkaYTpc44hd2ZiaIXtZY4hXS1{Nk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlEyQDJ7IN88US=> MX3TRW5ITVJ?
human HT-29 cells NXPYOmRCS3m2b4TvfIlkyqCjc4PhfS=> M{fCbFQ5KGh? NX;DbVFMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01NjNizszN NXO4Voh4OjB2MEW4OFk>
human RS4-11 cell M4nQVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\GeFIyUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR2N{O3JO69VQ>? M4js[HNCVkeHUh?=
human DB cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV3Pd5d{UW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuO|Y2OTlizszN MVfTRW5ITVJ?
human NB14 cell NV\ifoxbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnfQTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6xNlcyKM7:TR?= NGnUfohUSU6JRWK=
human BPH-1 cell NW\PSFNFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFPnPZJKdmirYnn0bY9vKG:oIHj1cYFvKEKSSD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{41OzZzMTFOwG0> NUDVOIpKW0GQR1XS
human PC3 cells MlrCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIjkfW82KGSjeYO= NEHie2tIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhT0l3ME23MlYh|ryP MonvNVg2PDN7MEK=
human EW-13 cell NVnWVG5[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz62NVA4QCEQvF2= MlmxV2FPT0WU
human NCI-H526 cell M2rxb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLMcYdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54OEK5NUDPxE1? MnXDV2FPT0WU
human NKM-1 cell M1u0SWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXzTVHZDUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDFyMEmg{txO NVe0WnJ{W0GQR1XS
human MDA-MB-453 cells MlPQR5l1d3SxeHnjxsBie3OjeR?= NH\NZWw1QCCq MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEWzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUmuOVEh|ryP Mn3KNlU4ODF{NUG=
human MEG-01 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{DJ[WlvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OTNzODFOwG0> M{\mdnNCVkeHUh?=
human NCI-H1648 cell NH\VOpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;kTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06Njd|NkG3JO69VQ>? MmHoV2FPT0WU
human LNCaP cells NGG3V2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWfT[IZOPiCmYYnz NGPpNo9Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNVkOjUDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExKM7:TR?= MoHFNVU3OTV3MkG=
human GP5d cell M2fHUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXXTY5pcWKrdHnvckBw\iCqdX3hckBIWDWmIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuNlY{PyEQvF2= MlzjV2FPT0WU
human MDA-MB-231 cells NEDzdZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV7lW|VlPSCmYYnz NIDqVXNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO|YYmsJGdKPTB;MUCuPFUh|ryP M{DudlE5PTR|OUCy
human DU145 cells M2jsZ2N6fG:2b4jpZ:Kh[XO|YYm= NEnvcJU1QCCq M3S0XmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTFzLk[0JO69VQ>? M1zZNlI2PzBzMkWx
human DEL cell MljvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37Nc2lvcGmkaYTpc44hd2ZiaIXtZY4hTEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuN|czQCEQvF2= MmrjV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
in solvent
Synonyms All-trans Retinoic Acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03999684 Recruiting Drug: Tretinoin Adenoid Cystic Carcinoma Dana-Farber Cancer Institute|The V Foundation|ACCRF August 5 2019 Phase 2
NCT03200847 Recruiting Drug: Pembrolizumab with All-Trans Retinoic Acid Stage IV Melanoma|Stage III Melanoma|Advanced Melanoma University of Colorado Denver|Merck Sharp & Dohme Corp. October 31 2017 Phase 1|Phase 2
NCT02620813 Completed Drug: Tretinoin|Drug: Isotretinoin Acne Vulgaris University of California Davis October 2015 Phase 4
NCT01969058 Completed Drug: Isotretinoin HIV-1 Infection AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) July 2014 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID