Retinoic acid (Tretinoin)

Catalog No.S1653 Batch:S165306

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Technical Data

Formula

C20H28O2

Molecular Weight 300.4 CAS No. 302-79-4
Solubility (25°C)* In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 2 mg/mL (6.65 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1]

Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

In vivo

Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1]

Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3]

Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4]

Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol (from reference)

Cell Assay:

[6]

  • Cell lines

    BE2C cells

  • Concentrations

    5 μM

  • Incubation Time

    6 days

  • Method

    Cells were treated with indicated concentration of drug for 6 days.

Animal Study:

[7]

  • Animal Models

    Female Skh-hairless-1 albino mice

  • Dosages

    0.05%

  • Administration

    Dorsal application

Customer Product Validation

Data from [Data independently produced by , , Cell, 2018, 175(5):1244-1258]

Selleck's Retinoic acid (Tretinoin) has been cited by 30 publications

The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer [ Cancers (Basel), 2024, 16(6)1178] PubMed: 38539513
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage [ Cell Res, 2023, 33(6):421-433] PubMed: 37085732
Generation of human otic neuronal organoids using pluripotent stem cells [ Cell Prolif, 2023, 56(5):e13434] PubMed: 36825797
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion [ Phytomedicine, 2023, 118:154942] PubMed: 37421767
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system [ J Cell Sci, 2023, 136(6)jcs259875] PubMed: 36825945
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system [ J Cell Sci, 2023, 136(6)jcs259875] PubMed: 36825945
Dynamic Plasticity Systems Direct Early Adaptation to Treatment in Neuroblastoma [ bioRxiv, 2023, 10.1101/2023.12.07.570359] PubMed: none
Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366] PubMed: 36012634
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746
ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury [ Cell Signal, 2022, 93:110304] PubMed: 35278669

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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