Tamibarotene

Catalog No.S4260

Tamibarotene Chemical Structure

Molecular Weight(MW): 351.44

Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.

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Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
Targets
RARα [1] RARβ [1]
In vitro

Tamibarotene slightly inhibits the growth of both myeloma cells and HUVECs, and remarkably inhibits the growth of HUVECs stimulated by VEGF. Tamibarotene shows little growth inhibition of bone marrow stromal cells (BMSCs), but it markedly inhibits migration of HUVECs by cocultured myeloma cells. Tamibarotene inhibits VEGF-induced phosphorylation of VEGF receptor. Tamibarotene significantly inhibits VEGF-induced formation of tube-like structures in vitro and neovascularization in mouse corneas. [1] Tamibarotene-induced HL-60 cell adhesion to ECs is 38% lower than All-trans retinoic acid (ATRA), and NB4 cell adhesion to ECs by tamibarotene is equivalent to ATRA, which induces CD38 gene transcription biphasically in HL-60 cells, the early-phase induction via DR-RARE containing intron 1, and the delayed-phase induction via RARE lacking the 5'-flanking region. Tamibarotene induces only the early-phase induction in HL-60 cells, resulting in its lower CD38 induction than ATRA. [2] Tamibarotene has negligible growth inhibition of peripheral blood mononuclear cells but marked growth inhibition of both HTLV-I-infected T-cell lines and ATL cells. Tamibarotene arrests cells in the G1 phase of the cell cycle and induces apoptosis in HTLV-I-infected T-cell lines. Tamibarotene inhibits also the phosphorylation of IkappaBalpha and NF-kappaB-DNA binding, in conjunction with reduction of expression of proteins involved in the G1/S cell cycle transition and apoptosis. Tamibarotene also inhibits the expression of JunD, resulting in suppression of AP-1-DNA binding. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NB4 cells MlvoVJJwdGmoZYLheIlwdiCjc4PhfS=> NXXQOlZYPDhiaB?= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6ENDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQvQDFizszN MWOyNlAyPDh{OR?=
HL60 cells MkjGVJJwdGmoZYLheIlwdiCjc4PhfS=> NGLLSHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOsJGlEPTB;NjFOwG0> MU[xPVQ1OzJ{NR?=
HL60 cells NF65[FNRem:uaX\ldoF1cW:wIHHzd4F6 NXrPOVViPDhiaB?= MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF05Njl2IN88US=> M{nXdFIzODF2OEK5
Jurkat cells M1;qb3Bzd2yrZnXyZZRqd25iYYPzZZk> MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEq3cnvheEBk\WyuczygTWM2OD1zNz6zJO69VQ>? MnLjNVk1PDN{MkW=
MOLT4 cells MYXQdo9tcW[ncnH0bY9vKGG|c3H5 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTGS0JINmdGy|LDDJR|UxRTF7LkWg{txO MljJNVk1PDN{MkW=
U937 cells NXT3SFhUWHKxbHnm[ZJifGmxbjDhd5NigQ>? MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNuIFnDOVA:OjBwMjFOwG0> NYPvV4k6OTl2NEOyNlU>
K562 cells NXT0cGtxWHKxbHnm[ZJifGmxbjDhd5NigQ>? NEjIOWI1QCCq NVLNT4liSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NEKuN|ch|ryP NHflTmIzOjBzNEiyPS=>
COS-1 cells M1PBZmZ2dmO2aX;uJIF{e2G7 MnLDWJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gbY4hS0:VLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDBZ4llKFKnY3XweI9zKGGucHjhJEhTSVJiYXzwbIEq M2fVU|ExPjZ7NU[4

... Click to View More Cell Line Experimental Data

In vivo Tamibarotene treatment reduces significantly the insoluble Abeta levels in brain of mice, in particular Abeta(42), while it gives no apparent effects on the soluble Abeta levels. [4]

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.18 mM)
Ethanol 70 mg/mL (199.18 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 351.44
Formula

C22H25NO3

CAS No. 94497-51-5
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID