Tamibarotene

For research use only.

Catalog No.S4260

1 publication

Tamibarotene Chemical Structure

Molecular Weight(MW): 351.44

Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.

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Selleck's Tamibarotene has been cited by 1 publication

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Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
Targets
RARα [1] RARβ [1]
In vitro

Tamibarotene slightly inhibits the growth of both myeloma cells and HUVECs, and remarkably inhibits the growth of HUVECs stimulated by VEGF. Tamibarotene shows little growth inhibition of bone marrow stromal cells (BMSCs), but it markedly inhibits migration of HUVECs by cocultured myeloma cells. Tamibarotene inhibits VEGF-induced phosphorylation of VEGF receptor. Tamibarotene significantly inhibits VEGF-induced formation of tube-like structures in vitro and neovascularization in mouse corneas. [1] Tamibarotene-induced HL-60 cell adhesion to ECs is 38% lower than All-trans retinoic acid (ATRA), and NB4 cell adhesion to ECs by tamibarotene is equivalent to ATRA, which induces CD38 gene transcription biphasically in HL-60 cells, the early-phase induction via DR-RARE containing intron 1, and the delayed-phase induction via RARE lacking the 5'-flanking region. Tamibarotene induces only the early-phase induction in HL-60 cells, resulting in its lower CD38 induction than ATRA. [2] Tamibarotene has negligible growth inhibition of peripheral blood mononuclear cells but marked growth inhibition of both HTLV-I-infected T-cell lines and ATL cells. Tamibarotene arrests cells in the G1 phase of the cell cycle and induces apoptosis in HTLV-I-infected T-cell lines. Tamibarotene inhibits also the phosphorylation of IkappaBalpha and NF-kappaB-DNA binding, in conjunction with reduction of expression of proteins involved in the G1/S cell cycle transition and apoptosis. Tamibarotene also inhibits the expression of JunD, resulting in suppression of AP-1-DNA binding. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NB4 cells M17vdnBzd2yrZnXyZZRqd25iYYPzZZk> M2ixNVQ5KGh? NVP6fFZLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDORlQh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12LkixJO69VQ>? MUmyNlAyPDh{OR?=
HL60 cells MXTQdo9tcW[ncnH0bY9vKGG|c3H5 NVv0cWN5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzMEBKSzVyPU[g{txO M4H0R|E6PDR|MkK1
HL60 cells NHvhSVZRem:uaX\ldoF1cW:wIHHzd4F6 M2DNRVQ5KGh? MnXORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC57NDFOwG0> M4DhR|IzODF2OEK5
Jurkat cells NI[5UYhRem:uaX\ldoF1cW:wIHHzd4F6 M2TFbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSoXyb4F1KGOnbHzzMEBKSzVyPUG3MlMh|ryP MlS4NVk1PDN{MkW=
MOLT4 cells Mn7PVJJwdGmoZYLheIlwdiCjc4PhfS=> NFLNWI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3PUHQ1KGOnbHzzMEBKSzVyPUG5MlUh|ryP MmXhNVk1PDN{MkW=
U937 cells NUDFS41yWHKxbHnm[ZJifGmxbjDhd5NigQ>? MoLXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|LDDJR|UxRTJyLkKg{txO M{XEOVE6PDR|MkK1
K562 cells NVnBTpBJWHKxbHnm[ZJifGmxbjDhd5NigQ>? NVrrOmZlPDhiaB?= NXz0VIt7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NEKuN|ch|ryP NXrZUpZ2OjJyMUS4Nlk>
COS-1 cells M3PldWZ2dmO2aX;uJIF{e2G7 NV\jdYF6XHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ1;TMVEh[2WubIOg[ZhxemW|c3nu[{BT\XSrbn;pZ{BC[2mmIGLlZ4VxfG:{IHHsdIhiKCiUQWKgZYxxcGFr MUWxNFY3QTV4OB?=

... Click to View More Cell Line Experimental Data

In vivo Tamibarotene treatment reduces significantly the insoluble Abeta levels in brain of mice, in particular Abeta(42), while it gives no apparent effects on the soluble Abeta levels. [4]

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.18 mM)
Ethanol 70 mg/mL (199.18 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 351.44
Formula

C22H25NO3

CAS No. 94497-51-5
Storage powder
in solvent
Synonyms N/A
Smiles CC1(C)CCC(C)(C)C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(O)=O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID